Content of lymphocytes with markers CD8+ and CD95+ in women 40-60 years old in the arctic region in normal and in pathology

Abstract

The natural discomfort of the North is determined by a combination of geographical, climatic, hydrological and other conditions and has an adverse impact on human health. Arterial hypertension (arterial hypertension) in the inhabitants of the North often proceeds malignantly, gives a high frequency of complications in the form of damage to target organs and is one of the most frequent and typical diseases in extreme conditions of nature and work. Early detection of hypertension, timely treatment that improves the quality of life of a person, especially women aged 40-60 years in conditions of increasing the retirement age, is extremely important. To determine the levels of cytotoxic activity and apoptosis in women 40-60 years old with a history of chronic pathology (arterial hypertension) and practically healthy (control). The complex of immunological examination of people included the determination of leukogram, phagocytic activity of neutrophils, phenotyping of lymphocytes: CD8+ (T-suppressor cells), CD95+ (Fas-ligand), using the method of indirect immunoperoxidase reaction using monoclonal antibodies in 116 women 40-60 years old living in the Far North of the Russian Federation (Nadym, Yamal-Nenets Autonomous District and Pinega, Arkhangelsk region). Among them: 46 people — persons with a history of chronic pathology (arterial hypertension) and 70 people — practically healthy persons. Thus, in women 40-60 years old with arterial hypertension, there is an increased content of the total number of lymphocytes, T-suppressors (CD8+), Fas-ligand (CD95+) in 4,30-60,90% of cases, depending on the indicator. Among healthy women aged 40-60 years, an increased content of T-suppressors (CD8+) and Fas-ligand (CD95+) in 47.88 and 21.12% of cases, respectively, indicates that they are at risk of developing hypertension.