2019
DOI: 10.1101/828012
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Contextual flexibility inPseudomonas aeruginosacentral carbon metabolism during growth in single carbon sources

Abstract: Pseudomonas aeruginosa is an opportunistic human pathogen, particularly noted for causing infections in the lungs of people with cystic fibrosis (CF). Previous studies have shown that the gene expression profile of P. aeruginosa appears to converge towards a common metabolic program as the organism adapts to the CF airway environment. However, at a systems level, we still have only a limited understanding of how these transcriptional changes impact on metabolic flux. To address this, we analysed the transcript… Show more

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Cited by 3 publications
(2 citation statements)
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“…At time point 9, the dominant populations of all three columns were from the genera Pseudomonas and Variovorax. Pseudomonas are facultative anaerobes capable of heterotrophic denitrification using a variety of carbon substrates (Dolan et al, 2020;Wu et al, 2019), and Variovorax genus includes species capable of denitrification and sulphate reduction (Crevecoeur, Vincent, Comte, & Lovejoy, 2015). The subsequent increase in diversity of each column and the further divergence in their populations are then due to differences in relative competitiveness of the species present as they adapt to the evolving geochemistry of each column by metabolic regulation (Ayuso, Acebes, López-Archilla, Montes, & Guerrero, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…At time point 9, the dominant populations of all three columns were from the genera Pseudomonas and Variovorax. Pseudomonas are facultative anaerobes capable of heterotrophic denitrification using a variety of carbon substrates (Dolan et al, 2020;Wu et al, 2019), and Variovorax genus includes species capable of denitrification and sulphate reduction (Crevecoeur, Vincent, Comte, & Lovejoy, 2015). The subsequent increase in diversity of each column and the further divergence in their populations are then due to differences in relative competitiveness of the species present as they adapt to the evolving geochemistry of each column by metabolic regulation (Ayuso, Acebes, López-Archilla, Montes, & Guerrero, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Bacteria of the genus Pseudomonas can be found in many habitats, including host-associated ones [1]. Several Pseudomonas strains have been found in plants [2][3][4] and animals [5][6][7] with a variety of phenotypes ranging from pathogenicity [3,8] to mutualism [5,9,10]. During recent years, some Pseudomonas strains were discovered to play a crucial role in helping different insects overcome biotic challenges such as pesticides or plant defence effectors [5,9,11].…”
Section: Introductionmentioning
confidence: 99%