Continual supplementation with n-3 fatty acids does not modify plasma lipid profile in spinal cord injury patients

Javierre, Casimiro; Vidal, Joan; Segura, Ramón; Medina, Josep R.; Garrido, Enrique

doi:10.1038/sj.sc.3101762

Cited by 11 publications

(4 citation statements)

References 22 publications

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“…29,83,84 Six months of omega-3 FA administration in a cohort of 19 men with SCI resulted in a 10-fold increase in plasma omega-3 FA values, but did not affect lipid profile. 85 However, the 2.25 g/day of omega-3 FA provided in this study may have been below the effective supplement dose range, which has been suggested to be 3-5 g/day. 86 Given the wide variety of proposed beneficial effects of omega-3 FA including lowering of TG, hypertension, and atherosclerotic plaque formation, 29,87,88 future investigations with more applicable dosing appear warranted.…”

Section: Nutritional Recommendationsmentioning

confidence: 80%

Evidence-based and heuristic approaches for customization of care in cardiometabolic syndrome after spinal cord injury

Nash

Cowan

Kressler

2012

The Journal of Spinal Cord Medicine

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Component and coalesced health risks of the cardiometabolic syndrome (CMS) are commonly reported in persons with spinal cord injuries (SCIs). These CMS hazards are also co-morbid with physical deconditioning and elevated pro-atherogenic inflammatory cytokines, both of which are common after SCI and worsen the prognosis for all-cause cardiovascular disease. This article describes a systematic procedure for individualized CMS risk assessment after SCI, and emphasizes evidence-based and intuitioncentered countermeasures to disease. A unified approach will propose therapeutic lifestyle intervention as a routine plan for aggressive primary prevention in this risk-susceptible population. Customization of dietary and exercise plans then follow, identifying shortfalls in diet and activity patterns, and ways in which these healthy lifestyles can be more substantially embraced by both stakeholders with SCI and their health care providers. In cases where lifestyle intervention utilizing diet and exercise is unsuccessful in countering risks, available pharmacotherapies and a preferred therapeutic agent are proposed according to authoritative standards. The over-arching purpose of the monograph is to create an operational framework in which existing evidence-based approaches or heuristic modeling becomes best practice. In this way persons with SCI can lead more active and healthy lives.

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Section: Nutritional Recommendationsmentioning

confidence: 80%

Evidence-based and heuristic approaches for customization of care in cardiometabolic syndrome after spinal cord injury

Nash

Cowan

Kressler

2012

The Journal of Spinal Cord Medicine

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“…[592829] Recent studies in normal volunteers indicate that the beneficial effects of dietary PUFA on risk of chronic inflammatory disease (cardiovascular disease, rheumatoid arthritis, asthma, and periodontitis)[510] is based on decrease in production of interleukins. [9]…”

Section: Discussionmentioning

confidence: 99%

“…In a previous and unique interventional study,[10] Javierre et al . evaluated the possible effect of n-3 PUFA (1.5 g of DHA and 0.75 g of EPA) on plasma lipid profile in 19 adult males with SCI for 6 months.…”

Section: Introductionmentioning

confidence: 99%

The effects of n-3 fatty acids on inflammatory cytokines in osteoporotic spinal cord injured patients: A randomized clinical trial

Sabour¹,

Norouzi²,

Shidfar³

et al. 2012

Bone

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“…10 Metabolic syndrome, including high blood pressure, hyperglycemia, dyslipidemia, and central adiposity, is more common in individuals with SCI than the general population. 6,[11][12][13][14][15][16][17] Consequently, SCI patients have increased risk of heart disease, stroke and diabetes, 13,[18][19][20][21][22][23] and increased morbidity and mortality compared with the general population. 6,12,13,19,20 Understanding why metabolic syndrome is more prevalent in the SCI population is an important clinical goal that requires a better understanding of what drives post-SCI organ responses.…”

Section: Introductionmentioning

confidence: 99%

Dietary Green Tea Extract Prior to Spinal Cord Injury Prevents Hepatic Iron Overload but Does Not Improve Chronic Hepatic and Spinal Cord Pathology in Rats

Goodus

Sauerbeck

Popovich

et al. 2018

Journal of Neurotrauma

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Spinal cord injury (SCI) disrupts autonomic regulation of visceral organs. As a result, a leading cause of mortality in the SCI population is metabolic dysfunction, and an organ central to metabolic control is the liver. Our recent work showed that rodent SCI promotes Kupffer cell (hepatic macrophage) activation, pro-inflammatory cytokine expression, and liver steatosis. These are symptoms of nonalcoholic steatohepatitis (NASH), the hepatic manifestation of metabolic syndrome, and these pre-clinical data replicate aspects of post-SCI human metabolic dysfunction. Because metabolic profile is highly dependent on lifestyle, including diet, it is likely that lifestyle choices prior to injury influence metabolic and hepatic outcomes after SCI. Therefore, in this study we tested if a diet rich in green tea extract (GTE), a known hepatoprotective agent, that began 3 weeks before SCI and was maintained after injury, reduced indices of liver pathology or metabolic dysfunction. GTE treatment significantly reduced post-SCI hepatic iron accumulation and blunted circulating glucose elevation compared with control-diet rats. However, GTE pre-treatment did not prevent Kupffer cell activation, hepatic lipid accumulation, increased serum alanine transaminase, or circulating non-esterified fatty acids, which were all significantly increased 6 weeks post-injury. Spinal cord pathology also was unchanged by GTE. Thus, dietary GTE prior to and after SCI had only a minor hepatoprotective effect. In general, for optimal health of SCI individuals, it will be important for future studies to evaluate how other lifestyle choices made before or after SCI positively or negatively impact systemic and intraspinal outcomes and the overall metabolic health of SCI individuals.

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Continual supplementation with n-3 fatty acids does not modify plasma lipid profile in spinal cord injury patients

Abstract: Study design: A prospective study during a diet modification. Objective: To observe the evolution of the plasma lipid profile in a group of spinal cord injury (SCI) patients given a supplement of a mixture of docosahexanoic acid (DHA) and eicosapentaenoic acid (EPA). Setting:

Cited by 11 publications

References 22 publications

Evidence-based and heuristic approaches for customization of care in cardiometabolic syndrome after spinal cord injury

Evidence-based and heuristic approaches for customization of care in cardiometabolic syndrome after spinal cord injury

The effects of n-3 fatty acids on inflammatory cytokines in osteoporotic spinal cord injured patients: A randomized clinical trial

Dietary Green Tea Extract Prior to Spinal Cord Injury Prevents Hepatic Iron Overload but Does Not Improve Chronic Hepatic and Spinal Cord Pathology in Rats

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