The effects of n-3 fatty acids on inflammatory cytokines in osteoporotic spinal cord injured patients: A randomized clinical trial

Sabour, Hadis; Norouzi, Abbas; Shidfar, Farzad; Vafa, Mohammadreza

doi:10.1016/j.bone.2012.02.489

Cited by 11 publications

(33 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The doses of EPA plus DHA administered to subjects were < 1.0 g/day in two trials (Sabour et al 2012;Zhou et al 2012), 1.0-1.9 g/day in nine trials (Atwell et al 2013;Damsgaard et al 2012;Helland et al 2001;Hill et al 2007b;Manley et al 2011;Mansoori et al 2016;Marques et al 2015;Santos et al 2013;Toupchian et al 2016), 2.0-2.9 g/day in seven trials (Freund-Levi et al 2014;Gorjão et al 2006;Garg 2012 2013a, b;Ramirez-Ramirez et al 2013;Vedin et al 2008), and 3-6 g/day in two trials (Kew et al 2004;Tihista and Echavarria 2017). Few studies used more than one dose: Kew et al (2003) used two dosages (0.77 g and 1.79 g EPA C DHA/day), Wallace et al (2003) and Gunnarsdottir et al (2008) used three dosages (0.44, 0.94 and 1.9 g EPA C DHA/day; and 0.26, 1.06 and 2.14 g EPA C DHA/day, respectively).…”

Section: Other Medical Aspectsmentioning

confidence: 99%

“…Cytokines were measured in eleven trials (Freund-Levi et al 2014;Gorjão et al 2006;Hill et al 2007b;Kew et al 2003;Kew et al 2004;Marques et al 2015;Ramirez-Ramirez et al 2013;Sabour et al 2012;Santos et al 2013;Vedin et al 2008;Wallace et al 2003); peripheral blood mononuclear cell functions (phagocytic activity, lymphocyte proliferation) were measured in seven trials (Gorjão et al 2006;Hill et al 2007b;Kew et al 2003;Kew et al 2004;Marques et al 2015;Santos et al 2013;Wallace et al 2003); the marker of monocyte/macrophage activation factor was measured in one trial (Toupchian et al 2016); allergy-related events, such as the incidence of bronchopulmonary dysplasia (Manley et al 2011) and the proportion of children hospitalised for lower respiratory tract conditions (Atwell et al 2013), were measured in two trials; bone mass and markers of bone formation were measured in one trial (Damsgaard et al 2012); the incidence of gestational diabetes mellitus and preeclampsia was measured in one trial (Zhou et al 2012); weight and fat mass were measured in six trials (Gunnarsdottir et al 2008;Helland et al 2001;Mansoori et al 2016;Garg 2012 2013a, b); and infectious complications were measured in one trial (Tihista and Echavarria 2017). Hill et al (2007b) reported that, while there was no effect on cytokine production by T cells and monocytes following supplementation with high DHA fish oil or exercise, supplementation with high DHA fish oil reduced superoxide production from stimulated neutrophils, while regular moderate exercise training protected bactericidal activity.…”

Section: Other Medical Aspectsmentioning

confidence: 99%

See 1 more Smart Citation

How does high DHA fish oil affect health? A systematic review of evidence

Fard

Wang

Sinclair

et al. 2018

Critical Reviews in Food Science and Nutrition

192

View full text Add to dashboard Cite

The health benefits of fish oil, and its omega-3 long chain polyunsaturated fatty acid content, have attracted much scientific attention in the last four decades. Fish oils that contain higher amounts of eicosapentaenoic acid (EPA; 20:5n-3) than docosahexaenoic acid (DHA; 22:6n-3), in a distinctive ratio of 18/12, are typically the most abundantly available and are commonly studied. Although the two fatty acids have traditionally been considered together, as though they were one entity, different physiological effects of EPA and DHA have recently been reported. New oils containing a higher quantity of DHA compared with EPA, such as fractionated and concentrated fish oil, tuna oil, calamari oil and microalgae oil, are increasingly becoming available on the market, and other oils, including those extracted from genetically modified oilseed crops, soon to come. This systematic review focuses on the effects of high DHA fish oils on various human health conditions, such as the heart and cardiovascular system, the brain and visual function, inflammation and immune function and growth/Body Mass Index. Although inconclusive results were reported in several instances, and inconsistent outcomes observed in others, current data provides substantiated evidence in support of DHA being a beneficial bioactive compound for heart, cardiovascular and brain function, with different, and at times complementary, effects compared with EPA. DHA has also been reported to be effective in slowing the rate of cognitive decline, while its possible effects on depression disorders are still unclear. Interestingly, gender- and age- specific divergent roles for DHA have also been reported. This review provides a comprehensive collection of evidence and a critical summary of the documented physiological effects of high DHA fish oils for human health.

show abstract

Section: Other Medical Aspectsmentioning

confidence: 99%

Section: Other Medical Aspectsmentioning

confidence: 99%

How does high DHA fish oil affect health? A systematic review of evidence

Fard

Wang

Sinclair

et al. 2018

Critical Reviews in Food Science and Nutrition

192

View full text Add to dashboard Cite

show abstract

“…Some investigations have also shown anti-inflammatory effects of ω-3 PUFAs 17 whereas others detected no significant changes of inflammatory cytokines after medical therapy with omega-3. 18 However, many studies have supported the potential neuroprotective and apoptosis-inhibitory effects of ω-3 PUFAs 19,20 which propose this medication as a treatment among patients with SCI. The purpose of this study was to investigate the effects of interventional therapy with ω-3 PUFAs in spinal cord injured patients on changes of leptin and adiponectin levels in plasma.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 fatty acids’ effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial

Sabour

Javidan

Latifi

et al. 2014

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Context: Omega-3 fatty acids have been recently proposed to induce neural improvement in patients with spinal cord injury (SCI) while affecting some hormones including leptin and adiponectin. Objectives: We tried to evaluate the effect of omega-3 fatty acids on circulatory concentrations of leptin and adiponectin among these patients. Design: This study is a double-blinded randomized clinical trial with intervention duration of 14 months. Setting: A tertiary rehabilitation center. Participants: Total of 104 patients with SCI who did not meet our exclusion criteria entered the study. Those with history of diabetes, cancer, endocrinology disease, acute infection, and use of special medications were excluded. Patients were divided randomly into the treatment and control group by using permuted balanced block randomization. Intervention: The treatment group received two MorDHA ® capsules per day (each capsule contain 465 mg of docosahexaenoic acid (DHA) and 63 mg of eicosapentaenoic acid (EPA)) for 14 months while the control group received placebo capsules with similar color, shape, and taste. Main outcomes measures: Leptin and adiponectin concentrations in plasma were measured at the beginning of trial and then after 6 and 14 months. Results: Fourteen months of treatment with DHA and EPA did not influence concentrations of leptin but adiponectin level was significantly decreased (P: 0.03). Weight was positively correlated with leptin level at stage 0 of trial (P: 0.008, r = 0.41) while this association was attenuated through stages of trial after intervention. Conclusion: Our data show that omega-3 fatty acids may not affect plasma concentrations of leptin but adiponectin level is decreased in patients with SCI. Moreover, this intervention influences the linear relationship between weight and leptin after 14 months administration of DHA and EPA.

show abstract

“…[2][3][4][5][6] Studies show that all patients with SCI show mostly osteopenia or osteoporosis of the hip, but BMD values in the rest of the body are more stable and the reduction of BMD which occurs in the spinal vertebrae in these patients is not large. 7,8 It seems that the factors predicting bone loss in spinal vertebra and long bones are rather different.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bone mineral loss in patients with chronic traumatic spinal cord injury in Iran

Javidan

Sabour

Latifi

et al. 2014

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Objectives: We described the associations between demographic and injury-related factors on bone mineral density (BMD) of the spine and the hip among adult patients with chronic spinal cord injury (SCI). Design: BMD in spinal and femoral bone sites were assessed. Multivariate analysis was performed to evaluate the relationship between anthropometric and injury-related factors with BMD. Serum level and amount of dietary intake of calcium, phosphor, and 25-hydroxy vitamin D were measured. Setting: A referral tertiary rehabilitation center in Iran. Participants: Patients with SCI who had no previous history of endocrine disorders and were not on specific medications entered the investigation. Those with non-traumatic SCI, pregnant, or with substance dependency were excluded as well. Interventions: No interventions were applied. Main study outcome measures: Dual X-ray absorptiometry was performed to estimate BMD. Body mass index was positively associated with higher femoral (P < 0.01, r = 0.56) and hip (P < 0.0001, r = 0.82) BMD only in female participants. The high prevalence of vitamin D deficiency (60%) was noticeable. Results: Older male patients revealed lower BMD only in spinal vertebrae (P < 0.02, r = −0.21). A significant higher BMD loss in lumbar vertebras in male patients with complete spinal cord lesion (P < 0.009) was detected. Spinal reduction of BMD was more severe when the level of injury was above T6 (P < 0.02). Conclusion: Along with the clarification of age, gender, post injury duration, and the other factors' effect on the BMD in the SCI patients, here we have also shown the noticeable prevalence of the 25-hydoxy vitamin D deficiency in these patients which needs attention.

show abstract

The effects of n-3 fatty acids on inflammatory cytokines in osteoporotic spinal cord injured patients: A randomized clinical trial

Cited by 11 publications

References 32 publications

How does high DHA fish oil affect health? A systematic review of evidence

How does high DHA fish oil affect health? A systematic review of evidence

Omega-3 fatty acids’ effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial

Evaluation of bone mineral loss in patients with chronic traumatic spinal cord injury in Iran

Contact Info

Product

Resources

About