Continued Sedentariness, Change in Sitting Time, and Mortality in Older Adults

León‐Muñoz, Luz M.; Martínez‐Gómez, David; Balboa-Castillo, Teresa; López-Garcı́a, Esther; Guallar‐Castillón, Pilar; Rodríguez‐Artalejo, Fernando

doi:10.1249/mss.0b013e3182897e87

Cited by 96 publications

(82 citation statements)

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“…Following PRISMA guidelines, 10 we identified 16 published [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] studies through a systematic review of six databases (PubMed, PsycINFO, EMBASE, Web of Science, Sport Discus and Scopus) from data base inception until October 30 th 2014, updating the search up to October 10 th 2015 (a detailed search description is provided in the appendix). We also obtained data from two additional studies where the pertinent data were available but not published.…”

Section: Data Sources Literature Search and Study Selectionmentioning

confidence: 99%

“…We used the same MET-values for intensity as in the original publications. For those studies that simply reported duration of specific physical activities 14,19,22 we assigned the following conventionally accepted intensity levels: walking, 3.3 METs; moderate intensity activity, 4 METs; vigorous intensity activity, 7 METs; and strenuous sports, 7.2 METs. 30 Therefore, our estimate of physical activity reflects participation in moderate and vigorous intensity activity (MVPA).…”

Section: Data Harmonisationmentioning

confidence: 99%

“…For the WHIOS study we used publicly available individual level data to perform the analyses. 29 All studies except for three [17][18][19] either excluded all participants with major chronic diseases at baseline or excluded deaths occurring within at least one year in sensitivity analyses. Two of the remaining three studies, 18,19 which included older participants, provided analyses for this metaanalysis in which deaths within the first two years were excluded.…”

Section: Data Analyses and Synthesesmentioning

confidence: 99%

“…29 All studies except for three [17][18][19] either excluded all participants with major chronic diseases at baseline or excluded deaths occurring within at least one year in sensitivity analyses. Two of the remaining three studies, 18,19 which included older participants, provided analyses for this metaanalysis in which deaths within the first two years were excluded. The remaining study 17 , which had a short follow-up period (mean, 2.8 years), analysed their data excluding those with baseline cardiovascular disease (CVD), diabetes and cancer.…”

Section: Data Analyses and Synthesesmentioning

confidence: 99%

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Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women

et al. 2016

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Lee, I. (2016). Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. The Lancet, 388, s. 1302Lancet, 388, s. -1310 Dette er siste tekst-versjon av artikkelen, og den kan inneholde små forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på www.sciencedirect.com: http://doi.org/10.1016/S0140-6736 (16) MethodsWe included data from 16 studies, of which 14 were identified through a systematic review of six databases from database inception until October 2015 and two were additional unpublished studies where pertinent data were available. All study data were analysed according to a harmonised protocol, which categorized reported daily sitting time and TV-viewing time into four standardised groups each, and physical activity into quartiles. We then combined data across all studies (N=1,005,791) to analyse the joint and stratified associations of daily sitting time and physical activity with all-cause mortality, and estimated summary hazard ratios using Cox regression. We repeated these analyses using TV-viewing time instead of daily sitting time. FindingsDaily sitting time was not associated with higher all-cause mortality rates among those in the most active quartile. Compared with the referent (<4 h of sitting per day and highest quartile of physical activity [>35.5 MET-hour/week]), there was no increased risk of dying during follow up in those who sat for more than 8h/day but who also reported >35.5 MET-hour/week of activity (HR=1.04; 95% CI, 0.99, 1.10). In contrast, those who sat the least (<4 h/day) and were in the lowest (<2.5 METhour/week) activity quartile had a significantly increased risk of dying during follow-up (HR=1.27, 95% CI, 1.22, 1.31). For TV viewing time, >3 hours/day was associated with higher mortality rates regardless of physical activity, except in the most active quartile, where mortality rates were significantly higher only in the >5 hours/day group. InterpretationHigh levels of moderate intensity physical activity (i.e. about 60 to 75 minutes per day) appear to eliminate the increased risk of death associated with high sitting time. However, this high activity level attenuates, but does not eliminate the increased risk associated with high TV viewing time.Funding None 3 INTRODUCTIONIn a seminal 1953 Lancet paper, Morris and colleagues demonstrated an increased risk of coronary heart disease (CHD) in London bus drivers compared with conductors.1 Since then, numerous observational studies have shown that lack of physical activity is a major risk factor for morbidity and premature mortality.2-4 Indeed, recent estimates indicate that not meeting physical activity recommendations is responsible for more than 5 million deaths globally each year.

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Section: Data Sources Literature Search and Study Selectionmentioning

confidence: 99%

Section: Data Harmonisationmentioning

confidence: 99%

Section: Data Analyses and Synthesesmentioning

confidence: 99%

Section: Data Analyses and Synthesesmentioning

confidence: 99%

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Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women

et al. 2016

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“…However, the study also had some limitations. First, sitting time was ascertained only at baseline; thus, despite the evidence of certain stability over time in older adults, some changes in this behavior may have occurred (29,30). It could have led to underestimating the effect of sitting time on mortality.…”

Section: Discussionmentioning

confidence: 99%