Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014

Prognostic factors for human papillomavirus–positive and negative oropharyngeal carcinomas

“…In the United States, the incidence of HPV‐positive OPSCC has steadily increased, most prominently among middle‐aged men, whereas the incidence of HPV‐negative OPSCC has significantly declined . Several case series have shown that the proportion of OPSCCs that are HPV positive has continued to increase in recent calendar periods …”

Systematic review on location and timing of distant progression in human papillomavirus‐positive and human papillomavirus‐negative oropharyngeal squamous cell carcinomas

“…1,2 Previously, the main causes of OPSCC were smoking and alcohol consumption, but 60%-70% of cases in most parts of the North-Western world are today associated with HPV-driven carcinogenesis. 1,2 Previously, the main causes of OPSCC were smoking and alcohol consumption, but 60%-70% of cases in most parts of the North-Western world are today associated with HPV-driven carcinogenesis.…”

Primary, secondary and tertiary prevention of human papillomavirus-driven head and neck cancers

“…These rates are too weak to induce herd immunity that could protect unvaccinated individuals and eradicate the disease. Second, men who are up to 4 times more affected by HPV-driven OPCs [9,31] (almost 80% of all cases) are generally not eligible for vaccination. Only Australia, the United States and Canada have adopted this measure in 2011/2012, but the coverage level remains extremely low (<10e20%) [32,33].…”