Continuous 24-hour electrocardiography in thyrotoxicosis before and after treatment

Northcote, Robin J.; Macfarlane, Peter W.; Kesson, C. M.; Ballantyne, D.

doi:10.1016/0002-8703(86)90272-3

Cited by 19 publications

(5 citation statements)

References 24 publications

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“…There are a few studies involving small numbers of subjects using Holter monitoring to determine the prevalence of dysrhythmias in hyperthyroid patients (15). Ventricular dysrhythmias were not more prevalent in hyperthyroidism in the present study, a finding consistent with previous small studies (15,35). The pathophysiology of supraventricular and ventricular arrhythmias differs in multiple respects, but the reason for the discrepancy observed in hyperthyroidism remains unclear.…”

Section: Discussionsupporting

confidence: 88%

Cardiovascular Manifestations of Hyperthyroidism Before and After Antithyroid Therapy

Osman

Franklyn

Holder

et al. 2007

Journal of the American College of Cardiology

132

133

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Section: Discussionsupporting

confidence: 88%

Cardiovascular Manifestations of Hyperthyroidism Before and After Antithyroid Therapy

Osman

Franklyn

Holder

et al. 2007

Journal of the American College of Cardiology

132

133

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“…In fact, under hyperthyroid conditions, antithyroid drug therapy, such as PTU or methimazole, is usually given to reduce T 3 plasma levels and thereby reduce the heart rate. 27 , 28 However, here we showed that the increased heart rate observed in pregnant mice remains after the use of PTU, although T 3 levels have returned to values found in nonpregnant mice. Based on these findings, it is unlikely that thyroid hormones would contribute significantly to the pregnancy-induced increased heart rate.…”

Section: Discussionmentioning

confidence: 42%

Pregnancy-induced increased heart rate is independent of thyroid hormones

2021

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Background The heart rate increases by 10–20 beats per minute (bpm) throughout pregnancy in women, reaching maximum heart rate in the third trimester. During pregnancy, important changes in thyroid hormones also occur, with increases of up to 50% in the levels of triiodothyronine (T 3 ), the biological active thyroid hormone. In addition, T 3 has been shown to regulate cardiac electrophysiology. Objective Thus, in the present study the potential contribution of T 3 in pregnancy-induced increased heart rate was explored. Methods We compared the heart rate between nonpregnant and pregnant mice under control conditions and after altering thyroid hormone levels with T 3 and propylthiouracil (PTU, an antithyroid drug) treatments. Results Consistent with the clinical data, we found a 58% rise in T 3 levels during pregnancy in mice. Although pregnant mice had a higher baseline heart rate (607 ± 8 bpm, P = .004) and higher T 3 levels (1.9 ± 0.4 nM, P = .0005) than nonpregnant mice (heart rate: 546 ± 16 bpm; T 3 levels: 1.2 ± 0.1 nM), their heart rate responded similarly to T 3 treatment as nonpregnant mice (nonpregnant: Δ130 ± 22 bpm; pregnant: Δ126 ± 17 bpm, P = .858). Additionally, the heart rate remained significantly elevated (607 ± 11 bpm, P = .038) and comparable to untreated pregnant mice, after the use of the antithyroid drug PTU, although T 3 levels (1.3 ± 0.2 nM, P = .559) returned to nonpregnant values. Conclusion Based on these results, it is unlikely that T 3 contributes significantly to the pregnancy-induced increased heart rate.

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“…This is in line with subclinical hyperthyroidism being typically associated with an increased heart rate (Figure 8) [42]. The second most common arrhythmia in overt hyperthyroidism is atrial fibrillation, which occurs in 10% -15% of patients with its prevalence increasing with age (Figure 9) [41]. Additionally, patients with subclinical hyperthyroidism are also at an increased risk of atrial fibrillation [42] [43].…”

Section: Hyperthyroidismmentioning

confidence: 54%

“…In approximately 40% of overt hyperthyroidism cases, sinus tachycardia is observed and generally resolves after the restoration of euthyroidism [41]. This is in line with subclinical hyperthyroidism being typically associated with an increased heart rate (Figure 8) [42].…”

Section: Hyperthyroidismmentioning

confidence: 65%

Electrocardiographic Manifestations of Endocrine and Metabolic Disorders

Amini,

Golchin,

Kharat

et al. 2023

OJEMD

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Endocrine dysfunction has an adverse impact on the cardiovascular system that may be due to an endocrine abnormality that leads to electrocardiogram (EKG) changes. The EKG changes due to endocrine disorder can be reversible and irreversible and treating underlying disease can reverse EKG changes in some cases. In this article, we review the electrocardiogram manifestations of various endocrine disorders.

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Continuous 24-hour electrocardiography in thyrotoxicosis before and after treatment

Cited by 19 publications

References 24 publications

Cardiovascular Manifestations of Hyperthyroidism Before and After Antithyroid Therapy

Cardiovascular Manifestations of Hyperthyroidism Before and After Antithyroid Therapy

Pregnancy-induced increased heart rate is independent of thyroid hormones

Electrocardiographic Manifestations of Endocrine and Metabolic Disorders

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