CONTINUOUS AND DISCONTINUOUS TREATMENT WITH ESTROGENS IN EXPERIMENTAL TUMORIGENESIS¹

Granulosa-cell tumours induced in mice by progesterone.

“…One will remember that according to Gardner (1955) even the granulosa-cell tumours in the intrasplenic grafts " appeared to arise from the germinal epithelium " (p. 116). Indeed, most of those who have worked with intrasplenic grafts were rather in favour of the cells of the stroma or of the theca being the matrix of the growth in intrasplenic ovarian grafts (Kullander, 1959;Guthrie, 1957;Lipschutz, 1960). The same seems to be true also for the microtumours originating in the kidney and the liver (Lipschutz, Panasevich and (erisola, 1964).…”

“…The question is of considerable interest when discussing the tumorigenic faculties of steroids; the fibromatogenic action of oestrogens fails when the latter are administered rhythmically, i.e. discontinuously (Lipschutz, Rodriguez and Vargas, 1941;Lipschutz, 1950, pp. 40-41).…”

“…Granulosa-cell tumours have been produced experimentally grafting the ovary into the spleen in rats (Biskind and Biskind, 1944), in mice (Li and Gardner, 1947;Gardner, 1955Gardner, , 1961Furth and Sobel, 1947), in guinea-pigs (Mardones, Iglesias and Lipschutz, 1955;summaries Lipschutz, 1950summaries Lipschutz, , 1957, and in rabbits (Peckham, Greene and Jeffries, 1948;Peckham and Greene, 1952). The evolution of these experimental ovarian tumours in mice and guinea-pigs also has been studied and summarized by various authorities (Guthrie, 1957(Guthrie, , 1959Kullander, 1954Kullander, , 1956Kullander, , 1959Lipschutz, 1957Lipschutz, , 1960Lipschutz, , 1963Lipschutz, Rojas, Cerisola and Iglesias, 1960;Lipschutz, Panasevich, Cerisola and Alvarez, 1965). The final structure of G induced by 19-nor-P or by P is apparently coincident with that of G in intrasplenic grafts.…”

Benign Diseases of the Uterine Fundus

“…The most convincing evidence involves persistent estrogenic activity, especially when unopposed by the activity of progesterone. Lipschutz and associates 15 and others were able to induce development of fibroids in the abdominal cavities of guinea pigs by prolonged administration of estrogens. These fibroids tended to regress when estrogenic therapy was withdrawn.…”