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Since this paper is the fourth paper of a group in which we have considered cyclic histological changes in the anterior pituitaries of dogs, sows, rats and rabbits, it seems desirable that we summarize and correlate our findings in these different species. For this reason, we have reviewed in some detail the cyclic histological changes occurring in the anterior lobe of the hypophysis of the dog (Wolfe, Cleveland and Campbell, '32 and '33), of the rat (Wolfe and Cleveland, '33) and of the sow (Cleveland and Wolfe, '33). Previous to the appearance of these papers, cyclic histological variations had been described in the anterior hypophysis of the woodchuck (Rasmussen, '21) and of the rat (Haterius and Charipper, '30, and Reese, '32).Early in the studies on the cyclic changes occurring in the anterior hypophysis, it was found that there were certain differences in the histology of the anterior pituitary glands of different species. Thus, it was thoughl, advisable to study anterior lobe tissue from several different species of animals exhibiting different types of oestral cycles. I n this way it has been possible to correlate the histological picture presented by the anterior hypophysis of any particular species with the type of oestral cycle exhibited by that species. 'This work has been supported by grants from t f e Committee on Scientific