The Effect of Testosterone on Experimentally Produced Endometrial Hyperplasia in the Guinea Pig1

Williams, Claiborne; Phelps, Doris; Burch, John C.

doi:10.1210/endo-25-2-312

Cited by 4 publications

(2 citation statements)

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“…The stroma was loose and edematous; its cells had small nuclei and sparse cytoplasm. The reaction in these specimens was clearly an exaggeration of the normal estrous reaction and it was similar in every respect to the condition produced in the castrate guinea pig endometrium as a result of prolonged treatment with estrogen (14)(15)(16).…”

Section: Resultssupporting

confidence: 54%

Observations on the Effect of Hypothyroidism on Ovarian Function in the Guinea Pig

1941

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Section: Resultssupporting

confidence: 54%

Observations on the Effect of Hypothyroidism on Ovarian Function in the Guinea Pig

1941

Self Cite

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“…Androgens produce the same effects on the liver, kidneys, spleen, and heart as in males. Some stimulation of uterine hyper trophy is observed (191) in the rat (192,193). In women and in monkeys high doses of testosterone propionate prevent uterine bleed ing (194,195).…”

Section: Separation Of Androgens and Related Compounds From Urinementioning

confidence: 97%

Hormones

Koch¹

1940

Annu. Rev. Biochem.

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Because the more definitely biochemical advances in the field of hormones are very nearly limited to those of the steroid type together with the limited space available for reviewing a very extensive litera ture, I have taken advantage of the editors' liberal policy and have limited this review to the biochemistry of the steroid hormones. ESTROGENSDistribution and forms of estrogens.-Although all of the estro gen activity in cow and hog ovaries is considered to be in the free form, only 50 to 75 per cent is free in the horse ovary or its follicular fluid (1). During pregnancy 50 to 75 per cent of the blood estrogens in women are in the free form (2). The best method of hydrolysis of the conjugated forms of estrogens in pregnancy urine is still a prob lem. One g.roup recommends boiling the pregnancy urine for ten minutes with 15 per cent concentrated hydrochloric added. Longer heating results in serious loss of estrogens (3). Others recommend that the urine from pregnant mares be allowed to stand at pH 0.4 to 0.6 at room temperature for at least four weeks (4). The writer, in studies on urine from normal men and nonpregnant women, has obtained the highest yield of estrogens by boiling the urine previously acidified to pH 1 to 1.2 with hydrochloric acid for fifteen minutes.Longer boiling at this pH also causes destruction of estrogens. The gradual increase in the urinary excretion of estrogens in women to a peak of 80,000 rat units near the termination has been confirmed, but in one case of toxemia of pregnancy, the excretion was subnormal.

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An evaluation of androgenic therapy in gynecologic practice

Huffman

1940

American Journal of Obstetrics and Gynecology

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The Effect of Testosterone on Experimentally Produced Endometrial Hyperplasia in the Guinea Pig1

Cited by 4 publications

References 0 publications

Observations on the Effect of Hypothyroidism on Ovarian Function in the Guinea Pig

Observations on the Effect of Hypothyroidism on Ovarian Function in the Guinea Pig

Hormones

An evaluation of androgenic therapy in gynecologic practice

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