Fatty acid methyl esters (FAMEs) are sustainable biofuel that can alleviate high oil costs and environmental impacts of petroleum-based fuel. A modified 1200 W high-efficiency food blender was employed for continuous transesterification of various refined vegetable oils and waste cooking oil (WCO) using sodium hydroxide as a homogeneous catalyst. The following factors have been investigated on their effects on FAME yield: baffles, reaction volume, total reactant flow rate, methanol-oil molar ratio, catalyst concentration and reaction temperature. Results indicated that the optimal conditions were: 2000 mL reaction volume, 50 mL/min total flow rate, 1% and 1.25% catalyst concentration for refined palm oil and WCO, respectively, 6:1 methanol-to-oil molar ratio and 62–63 °C, obtaining yield efficiency over 96.5% FAME yield of 21.14 × 10–4 g/J (for palm oil) and 19.39 × 10–4 g/J (for WCO). All the properties of produced FAMEs meet the EN 14214 and ASTM D6751 standards. The modified household food blender could be a practical and low-cost alternative biodiesel production apparatus for continuous biodiesel production for small communities in remote areas.