SummaryThis study was performed to determine the interchangeability of femoral artery pressure and radial artery pressure measurements as the input for the PiCCO system (Pulsion Medical Systems, Munich, Germany). We studied 15 intensive care patients following cardiac surgery. Five‐second averages of the cardiac output derived from the femoral artery pressure (COfem) were compared to 5‐s averages derived from the radial artery pressure (COrad). One patient was excluded due to problems in the pattern recognition of the arterial pressure signal. In the remaining 14 patients, 14 734 comparative cardiac output values were analysed. The mean sample time was 88 min, range [30–119 min]. Mean (SD) COfem was 6.24 (1.1) l.min−1 and mean COrad 6.23 (1.1) l.min−1. Bland‐Altman analysis showed an excellent agreement with a bias of − 0.01 l.min−1, and limits of agreement from 0.60 to − 0.62 l.min−1. If changes in CO were > 0.5 l.min−1, the direction of changes in COfem and COrad were equal in 97% of instances. We conclude that femoral artery pressure and radial artery pressure are interchangeable as inputs for the PiCCO device.