Continuous chromatographic process based on SMB technology

Chiang, Anthony S.T.

doi:10.1002/aic.690440823

Cited by 35 publications

(18 citation statements)

References 8 publications

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“…If only continuous chromatography is to be used, the installation of more than four separation zones is required. The consecutive coupling of two independent four-zone SMB units was described, for example, in [80,81]. An example of an installation of nine integrated zones was suggested in [82].…”

Section: G Ternary and Pseudo-ternary Separationsmentioning

confidence: 99%

New Developments in Simulated Moving Bed Chromatography

2008

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Chromatographic separation processes are widely used to isolate and purify value added products. Most frequently, such separation processes are performed exploiting the principles of injecting samples of the feed mixture in a repetitive periodic manner and collecting the target products batchwise. In the early 1960s, an alternative operation principle based on using several columns connected in series and exploiting a continuous countercurrent movement between the mobile and stationary phases initiated significant improvements in performing specific separation processes in the petrochemical and sugar industries. In the last decade, the so-called simulated moving bed (SMB) chromatography has rapidly entered the pharmaceutical industry. In particular enantioseparations using chiral stationary phases have become a strong driving force to develop more sophisticated concepts of continuous chromatography. Currently, the growing interest in efficient methods for the downstream processing of biomolecules enhances interest in SMB processes. This paper gives a brief overview of the new suggestions and trends. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [accessed July 4, 2008

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Section: G Ternary and Pseudo-ternary Separationsmentioning

confidence: 99%

New Developments in Simulated Moving Bed Chromatography

2008

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“…If the target substance is neither the strongest nor the less-adsorbed component but has the middle position of three peaks in an elution chromatogram, additional separation zones are needed. For the separation of ternary mixtures Chiang [34] proposed either a combination of two 4-zone-SMB plants (as is the usual approach in the area of countercurrent extraction and distillation) or alternatively the design of an SMB plant with eight zones. Beste and Arlt [35] investigated a sidestream withdrawal for the separation of ternary mixtures by SMB chromatography.…”

Section: Applications Of Smb Chromatographymentioning

confidence: 99%

Modeling of Simulated Moving‐bed Chromatography

Johannsen

2007

Modeling of Process Intensification

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“…Multi-component separations have been performed by some alternative SMB configurations, as for example: two (or more) SMB units in cascade (Wankat 2001;Kim and Wankat 2004;Hur and Wankat 2006), SMB with three outlet ports (Navarro et al 1997;Beste and Arlt 2002;Wang and Ching 2005), eight (and nine) sections SMB (Chiang 1998;Wooley et al 1998) and pseudo-Simulated Moving Bed (pseudo-SMB) (Ando et al 1990). Considering the pseudo-SMB, this configuration refers to the JO technology developed by Japan Organo Co. (Ando et al 1990), which has been discussed in some publications: Sayama et al (1992) have experimentally tested this technology for separation of raffinose from beet molasses, Mata and Rodrigues (2001) have developed a pseudo-SMB model for such process, Kurup et al (2006) have considered multi-objective optimization of these units, and Borges da Silva and Rodrigues (2006) analyzed JO performances and suggested an extended JO for quaternary separations.…”

Section: Introductionmentioning

confidence: 99%

Simulated moving bed technology to improve the yield of the biotechnological production of lactobionic acid and sorbitol

2010

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This work presents an analysis on the suitability of the Simulated Moving Bed (and pseudo-SMB) technology on separating the mixture obtained from the lactose oxidation catalyzed by glucose-fructose oxidoreductase and glucono-α-lactonase enzymes. These enzymes from the Zymomonas mobilis bacteria are able to oxidize lactose in presence of fructose to its respective organic acid-lactobionic acid-and sorbitol. Some alternative arrays of chromatographic systems, as fixed bed column, SMB unit, 4 section pseudo-SMB, have been explored to separate the multicomponent mixture, in such way to make possible the product recovery and the recycle of substrates to the enzymatic reactor. This study involved the definition of appropriate operating conditions and the prediction of the performance of the separation units, or arrangement of units, through modeling and simulations tools. To define the proper operating conditions, inequalities from equilibrium theory and the concept of the separation volume analysis have been considered. In this analysis, equilibrium and kinetic parameters for the compounds adsorbing on DOWEX 50W-X4 resin, in K + and Ca +2 ion-loadings, have been obtained from chromatographic methods (pulse and adsorption-desorption techniques). bionic acid and sorbitol using permeabilized cells of Z. mobilis is shown. The strategy of keeping the highest value of reaction rate by the integration of a chromatographic system proved to be viable when it was found the feasibility to apply the SMB system in cascade.

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Continuous chromatographic process based on SMB technology

Cited by 35 publications

References 8 publications

New Developments in Simulated Moving Bed Chromatography

New Developments in Simulated Moving Bed Chromatography

Modeling of Simulated Moving‐bed Chromatography

Simulated moving bed technology to improve the yield of the biotechnological production of lactobionic acid and sorbitol

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