Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon

Zhang, Ziyang; Mazzotti, Marco; Morbidelli, Massimo

doi:10.1007/bf02705435

Cited by 70 publications

(42 citation statements)

References 26 publications

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“…Finally, it should be mentioned that recently an instructive comparison between the PowerFeed, ModiCon and VariCol processes has been published [39] revealing that, due to their specific additional degrees of freedom, all three modes offer the potential to outperform the conventional SMB-process.…”

Section: A3 Asynchronous Shifts (Varicol)mentioning

confidence: 98%

New Developments in Simulated Moving Bed Chromatography

2008

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Chromatographic separation processes are widely used to isolate and purify value added products. Most frequently, such separation processes are performed exploiting the principles of injecting samples of the feed mixture in a repetitive periodic manner and collecting the target products batchwise. In the early 1960s, an alternative operation principle based on using several columns connected in series and exploiting a continuous countercurrent movement between the mobile and stationary phases initiated significant improvements in performing specific separation processes in the petrochemical and sugar industries. In the last decade, the so-called simulated moving bed (SMB) chromatography has rapidly entered the pharmaceutical industry. In particular enantioseparations using chiral stationary phases have become a strong driving force to develop more sophisticated concepts of continuous chromatography. Currently, the growing interest in efficient methods for the downstream processing of biomolecules enhances interest in SMB processes. This paper gives a brief overview of the new suggestions and trends. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [accessed July 4, 2008

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Section: A3 Asynchronous Shifts (Varicol)mentioning

confidence: 98%

New Developments in Simulated Moving Bed Chromatography

2008

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“…Dann wird mit Hilfe eines kommerziellen Flowsheet-Simulators ein Vergleich bezüg-lich des spezifischen Energiebedarfs zwischen dem herkömmlichen Prozess (sequentielle Reaktion und Trennung) und dem auf dem SMBR basierenden Prozess (integrierte Reaktion und Trennung) vorgestellt. [29,30] verwendet, der sehr gute Konvergenzeigenschaften zeigte. Die auf den ermittelten Parametern basierenden Simulationskurven sind ebenfalls in den Abbn.…”

Section: Experimentelle Ergebnisseunclassified

Reaktive Chromatographie

Ströhlein

Assunção

Morbidelli

et al. 2005

Chemie Ingenieur Technik

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“…Other possible configurations of multicolumn units based on the SMB principle have been proposed in (Zhang et al, 2004). However, none of them is able to apply a modifier gradient, which is essential in all purifications of biomolecules mentioned above.…”

Section: Introductionmentioning

confidence: 98%

A continuous multicolumn countercurrent solvent gradient purification (MCSGP) process

Aumann

Morbidelli

2007

Biotech & Bioengineering

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182

101

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Biomolecules are often purified via solvent gradient batch chromatography. Typically suitable smooth linear solvent gradients are applied to obtain the separation between the desired component and hundreds of impurities. The desired product is usually intermediate between weakly and strongly adsorbing impurities, and therefore a central cut is required to get the desired pure product. The stationary phases used for preparative and industrial separations have a low efficiency due to strong axial dispersion and strong mass transfer resistances. Therefore a satisfactory purification often cannot be achieved in a single chromatographic step. For large scale productions and for very valuable molecules, countercurrent operation such as the well known SMB process, is needed in order to increase separation efficiency, yield and productivity. In this work a novel multicolumn solvent gradient purification process (MCSGP-process) is introduced, which combines two chromatographic separation techniques, which are solvent gradient batch and continuous countercurrent SMB. The process consists of several chromatographic columns, which are switched in position opposite to the flow direction. Most of the columns are equipped with a gradient pump to adjust the modifier concentration at the column inlet. Some columns are interconnected, so that non pure product streams are internally, countercurrently recycled. Other columns are short circuited and operate in batch mode. As a working example the purification of an industrial stream containing 46% of the hormone Calcitonin is considered. It is found that for the required purity the MCSGP unit achieves a yield close to 100% compared to a maximum value of a single column batch chromatography of 66%.

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Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon

Cited by 70 publications

References 26 publications

New Developments in Simulated Moving Bed Chromatography

New Developments in Simulated Moving Bed Chromatography

Reaktive Chromatographie

A continuous multicolumn countercurrent solvent gradient purification (MCSGP) process

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