Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer

Lawton, Simon; Steele, G.; Shering, P.; Zhao, Lihua; Laird, Ian; Ni, Xiongwei

doi:10.1021/op900237x

Cited by 286 publications

(287 citation statements)

References 30 publications

Supporting

Mentioning

278

Contrasting

Order By: Relevance

“…As a result, there is often near perfect mixing in the radial direction and limited dispersion in the axial direction, which means that the assumptions of a plug flow device are likely to apply. A relatively high slurry mean velocity along the tube is required to avoid the sedimentation of crystals (or, in the case of an oscillatory baffled crystallizer 17 , high-frequency oscillations are introduced to suspend the crystals and produce a narrow residence time distribution, but not perfect plug flow, as is discussed at the end of this section). Often it is reasonable to assume that the tubular crystallizer is a plug-flow crystallizer and therefore requires only one spatial dimension, i.e., the tube axial length, in a mathematical model.…”

Section: Mathematical Modelling Of Plug-flow Crystallizermentioning

confidence: 99%

Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Benyahia

Nagy

et al. 2015

Org. Process Res. Dev.

View full text Add to dashboard Cite

Just Accepted "Just Accepted" manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides "Just Accepted" as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. "Just Accepted" manuscripts appear in full in PDF format accompanied by an HTML abstract. "Just Accepted" manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). "Just Accepted" is an optional service offered to authors. Therefore, the "Just Accepted" Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the "Just Accepted" Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these "Just Accepted" manuscripts. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 TABLE OF CONTENTS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 The configuration in which anti-solvent could be added at a variety of different locations along the tube length and at optimal flow rates was able to outperform previous designs in the literature which considered equally-spaced anti-solvent additions. The use of dynamic models to detect problems during startup of an MSMA-PFC was also highlighted.

show abstract

Section: Mathematical Modelling Of Plug-flow Crystallizermentioning

confidence: 99%

Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Benyahia

Nagy

et al. 2015

Org. Process Res. Dev.

View full text Add to dashboard Cite

show abstract

“…These processes have been identified as a more efficient method of separating and purifying pharmaceutical compounds, than traditional batch crystallisation processes. 149 The reactor design was compartmentalised into three temperature controlled sections. Each section of the part has channel networks above and below the reactor flow path, which are designed to have heated and cooled fluids pumped through.…”

Section: Sl Partmentioning

confidence: 99%

Design and additive manufacture for flow chemistry

et al. 2013

View full text Add to dashboard Cite

“…[44] developed a continuously operated oscillatory baffled flow device for chemical synthesis [45,46] and crystallization [45,[47][48][49] application, whereas the multiphase mixtures are dispersed by means of a pulsed flow through orifices. Further possible applications were claimed, such as liquid-liquid separation [46].…”

Section: Introductionmentioning

confidence: 99%

“…Further possible applications were claimed, such as liquid-liquid separation [46]. For the crystallization application, this type of equipment is often referred to as "continuous oscillatory baffled crystallizer" (COBC) [47]. Commercially available equipment ranges from V = 1.25 to 3.50 L internal volume for the DN15 device [44], and a DN25 device with V = 12 L was reported [47].…”

Section: Introductionmentioning

confidence: 99%

Separation Units and Equipment for Lab-Scale Process Development

Hohmann¹,

Kurt²,

Soboll³

et al. 2016

J Flow Chem

View full text Add to dashboard Cite

For complete chemical processes, downstream operation steps are essential, but on a miniaturized scale, they are not so far developed as the microreactors. This contribution presents three different unit operations for phase and component separation. Liquid-liquid extraction is often performed in columns, which were miniaturized for higher separation efficiency and flow rates suitable for processes in flow chemistry. Two-phase mass transfer processes in capillaries benefit from rapid final phase separation, which can be performed in an in-line phase splitter based on different surface wetting behavior. Crystallization is often a final purification step, which is performed in a continuously operated helical tube setup with narrow residence time distribution. For all unit operations, design criteria are shown with typical applications. The methodology of downscaling of known equipment and employing typical microscale phenomena such as good flow control, laminar flow, or dominant surface forces leads to successful equipment design.

show abstract

Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer

Cited by 286 publications

References 30 publications

Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Design and additive manufacture for flow chemistry

Separation Units and Equipment for Lab-Scale Process Development

Contact Info

Product

Resources

About