Continuous glucose monitoring by intravenous microdialysis

Rooyackers, Olav; Blixt, Christina; Mattsson, Per; Wernerman, Jan

doi:10.1111/j.1399-6576.2010.02264.x

Cited by 19 publications

(17 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dahlin et al were able to increase the MD recovery by using human CSF as perfusion fluid in an in vitro model (46). The MD recovery for the CMA64 catheter in peripheral blood is about 80% for glucose (39), lower than what is seen in our study.…”

Section: Discussioncontrasting

confidence: 89%

“…In our system, metabolites from a flow of CSF were measured using a CMA64 MD catheter, which might be the cause of the higher observed MD recovery if compared to the studies by Hutchinson et al (65–67%) (40) and Rooyackers et al (80%) (39). This finding was in coherence with the manufacturer, who routinely checks the calibration of MD catheters and measures levels of metabolites in known concentrations, in vitro .…”

Section: Discussionmentioning

confidence: 88%

“…Membrane length and dialysis perfusion flow rate are factors known to affect recovery and were thus standardized for all catheters used (37). The CMA64 catheter has, when placed in a peripheral vein, shown an adequate congruence (80% MD recovery) between CMA64 MD-glucose and plasma glucose levels (38, 39). …”

Section: Methodsmentioning

confidence: 97%

See 2 more Smart Citations

Microdialysis Monitoring of CSF Parameters in Severe Traumatic Brain Injury Patients: A Novel Approach

et al. 2014

View full text Add to dashboard Cite

Background: Neuro-intensive care following traumatic brain injury (TBI) is focused on preventing secondary insults that may lead to irreversible brain damage. Microdialysis (MD) is used to detect deranged cerebral metabolism. The clinical usefulness of the MD is dependent on the regional localization of the MD catheter. The aim of this study was to analyze a new method of continuous cerebrospinal fluid (CSF) monitoring using the MD technique. The method was validated using conventional laboratory analysis of CSF samples. MD-CSF and regional MD-Brain samples were correlated to patient outcome.Materials and Methods: A total of 14 patients suffering from severe TBI were analyzed. They were monitored using (1) a MD catheter (CMA64-iView, n = 7448 MD samples) located in a CSF-pump connected to the ventricular drain and (2) an intraparenchymal MD catheter (CMA70, n = 8358 MD samples). CSF-lactate and CSF-glucose levels were monitored and were compared to MD-CSF samples. MD-CSF and MD-Brain parameters were correlated to favorable (Glasgow Outcome Score extended, GOSe 6–8) and unfavorable (GOSe 1–5) outcome.Results: Levels of glucose and lactate acquired with the CSF-MD technique could be correlated to conventional levels. The median MD recovery using the CMA64 catheter in CSF was 0.98 and 0.97 for glucose and lactate, respectively. Median MD-CSF (CMA 64) lactate (p = 0.0057) and pyruvate (p = 0.0011) levels were significantly lower in the favorable outcome group compared to the unfavorable group. No significant difference in outcome was found using the lactate:pyruvate ratio (LPR), or any of the regional MD-Brain monitoring in our analyzed cohort.Conclusion: This new technique of global MD-CSF monitoring correlates with conventional CSF levels of glucose and lactate, and the MD recovery is higher than previously described. Increase in lactate and pyruvate, without any effect on the LPR, correlates to unfavorable outcome, perhaps related to the presence of erythrocytes in the CSF.

show abstract

Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 88%

See 1 more Smart Citation

Microdialysis Monitoring of CSF Parameters in Severe Traumatic Brain Injury Patients: A Novel Approach

et al. 2014

View full text Add to dashboard Cite

show abstract

“…These figures should be compared to plasma glucose analyses sampled at the same time point in an artery and a peripheral vein in stable healthy volunteers, giving a limit of agreement of 12% [16]. However, as mentioned above during fast changes in glucose due to clinical interferences, these two different sites might respond differently.…”

Section: Discussionmentioning

confidence: 99%

“…However, in critically ill patients the peripheral route is not always accessible and a central vein solution might be preferred[16]. In addition, a central vein allows for a catheter with a larger membrane surface, which has been shown to improve the agreement to plasma readings.The purpose of this study was to test a central venous catheter with a microdialysis membrane in combination withan on-line analyser and monitor as a principle for CGM.…”

Section: Introductionmentioning

confidence: 99%

Continuous on-line glucose measurement by microdialysis in a central vein. A pilot study

et al. 2013

View full text Add to dashboard Cite

IntroductionTight glucose control in the ICU has been proven difficult with an increased risk for hypoglycaemic episodes. Also the variability of glucose may have an impact on morbidity. An accurate and feasible on-line/continuous measurement is therefore desired. In this study a central vein catheter with a microdialysis membrane in combination with an on-line analyzer for continuous monitoring of circulating glucose and lactate by the central route was tested.MethodsA total of 10 patients scheduled for major upper abdominal surgery were included in this observational prospective study at a university hospital. The patients received an extra central venous catheter with a microdialysis membrane placed in the right jugular vein. Continuous microdialysis measurement proceeded for 20 hours and on-line values were recorded every minute. Reference arterial plasma glucose and blood lactate samples were collected every hour.ResultsMean microdialysis-glucose during measurements was 9.8 ± 2.4mmol/l.No statistical difference in the readings was seen using a single calibration compared to eighth hour calibration (P =0.09; t-test). There was a close agreement between the continuous reading and the reference plasma glucose values with an absolute difference of 0.6+0.8mmol, or 6.8+9.3% and measurements showed high correlation to plasma readings (r = 0.92). Thelimit of agreement was 23.0%(1.94 mmol/l) compared to arterial plasma values with a line of equality close to zero.However, in a Clarke-Error Grid 93.3% of the values are in the A-area,and the remaining part in the B-area.Mean microdialysis-lactate was 1.3 ± 1.1mmol/l. The measurements showed high correlation to the blood readings (r = 0.93).ConclusionContinuous on-line microdialysis glucose measurement in a central vein is a potential useful technique for continuous glucose monitoring in critically ill patients, but more improvements and testingare needed.

show abstract

Microdialysis in Metabolic Research

Jansson

2012

Microdialysis in Drug Development

View full text Add to dashboard Cite

Continuous glucose monitoring by intravenous microdialysis

Cited by 19 publications

References 16 publications

Microdialysis Monitoring of CSF Parameters in Severe Traumatic Brain Injury Patients: A Novel Approach

Microdialysis Monitoring of CSF Parameters in Severe Traumatic Brain Injury Patients: A Novel Approach

Continuous on-line glucose measurement by microdialysis in a central vein. A pilot study

Microdialysis in Metabolic Research

Contact Info

Product

Resources

About