Continuous Intra-Arterial Infusion and Intermittent Intra-Arterial Injection

Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”?

“…For over six decades intra-arterial (IA) drugs have been proposed for the treatment of lethal brain diseases. [1][2][3][4] Recent reports of super-selective intraarterial (IA) injections of bevacizumab for treating human gliomas have brought IA drug delivery back into focus. [5][6][7][8] In contrast to treatment of brain cancers the interest in IA chemotherapy for treating liver and breast cancers has considerably increased in the last three decades [ Figure 1].…”

A Chemist's View of Cancer Prevention

“…Epodyl was effective in treating some bone tumours of dogs (Owen 1964). It has been mainly used for treatment by arterial perfusion using doses of 1 to 2 ml of the pure substance particularly in cases with cancer of the head and neck (Westbury 1963, Harrison 1963).…”

Modern Aspects of Medical Treatment of Malignancy: The Use and Abuse of Cytotoxic Agents

“…Extracorporeal Perfusion (Irvine 1963) This elaborate technique was initially applied to various types of cancer but for practical purposes is now confined to the treatment of malignant melanoma of the limbs. (Westbury 1963) Simple intra-arterial administration of cytotoxic drugs, whether by repeated injection ofcontinuous infusion is usually conducted via a fine indwelling plastic catheter. The catheter is introduced either by surgical exposure of the artery or, where more appropriate, by percutaneous puncture.…”