Continuous Metabolic Syndrome Score in Children: How Useful is it?

Sharma, Rajni

doi:10.1007/s12098-019-03047-7

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…To the best of our knowledge, the present is the first study to compare the validity of different cMetS scores using MetS risks in Spanish adolescents. These findings are relevant considering the existence of studies suggesting that cMetS scores are more reliable than the dichotomous definition of MetS for discrimination in adolescents [ 14 , 28 , 29 ]. Other studies also suggest that a continuous scale is statistically more sensitive and less error-prone compared to the dichotomous approach [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 89%

cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents

Fernández-Aparicio

Perona

Alonso

et al. 2022

JPM

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The definition of metabolic syndrome (MetS) based on dichotomous cut-off points is efficient in the adult population. However, to date, there is no international consensus on how to define MetS in the pediatric population. For that reason, a continuous MetS score (cMetS) has been proposed for the pediatric population. However, despite multiple attempts, cMetS has not been fully validated as there is no agreement about the most accurate score to calculate it. The purpose of the present study was to compare the validity of different scores (three siMS scores, z-score, principal components analysis (PCA), the sum of PCA, and confirmatory factor analysis) to calculate cMetS and determine MetS in Spanish adolescents. There were 981 subjects, ranging 11–16 years old, recruited for this cross-sectional study. Seven different approaches to pediatric cMetS scores were calculated. All cMetS scores calculated strongly correlated with each other, especially siMS scores. The area under the curve obtained from receiving operating characteristic curves was particularly elevated for z-scores 0.81 (95% CI: 0.784–0.838), showing a specificity of 64.4%. Our study shows that cMetS based on z-scores is accurate and efficient to be used for research instead of the dichotomized definition of MetS in adolescents; and cMetS based on siMS scores is useful for clinical practice.

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Section: Discussionmentioning

confidence: 89%

cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents

Fernández-Aparicio

Perona

Alonso

et al. 2022

JPM

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“…To the best of our knowledge, the present study provides the first assessment of the strength of the independent association of MetS and UA with FLD. On the other hand, we also acknowledge major study limitations that include crosssectional design, lack of normal-weight individuals, use of population specific z-scores for metabolic variables 36 Therefore, we could not explore the association between levels of uric acid and grade of steatosis and, more importantly, any relationship to non-alcoholic steatohepatitis. Furthermore, we could not adjust our analyses for dietary intake, that is, of fructose and simple sugars, and physical activity levels.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, the present study provides the first assessment of the strength of the independent association of MetS and UA with FLD. On the other hand, we also acknowledge major study limitations that include cross‐sectional design, lack of normal‐weight individuals, use of population specific z‐scores for metabolic variables 36 that are not generalizable and need replication in different populations, and investigation of fatty liver by ultrasounds without grading the severity of fatty liver infiltration or the parenchyma derangement. Therefore, we could not explore the association between levels of uric acid and grade of steatosis and, more importantly, any relationship to non‐alcoholic steatohepatitis.…”

Section: Uric Acid and Fatty Liver Diseasementioning

confidence: 99%

Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity

Bonito¹,

Valerio

Licenziati

et al. 2022

Diabetes Metabolism Res

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Aims:To compare the association of high serum uric acid (HUA) or metabolic syndrome (MetS) with fatty liver disease (FLD) in youths with overweight/obesity (OW/OB). Materials and Methods: Cross-sectional study of anthropometrics, biochemical variables, and liver ultrasound of 3104 individuals with OW/OB (age 5-17 years). Metabolic syndrome was defined by ≥ 3 criteria among (1) high waist circumference; (2) high triglycerides; (3) low high-density lipoproteins; (4) fasting glucose ≥100 mg/ dl; (5) blood pressure ≥95 th percentile in children, and ≥130/80 mmHg in adolescents. High serum uric acid was defined as serum UA value ≥ 75 th percentile adjusted for sex. Fatty liver disease was determined by echography. Results: The sample was stratified in four categories: (1) no HUA, no MetS (reference category); (2) MetS; (3) HUA; (4) HUA and MetS (HUA + MetS

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A considerable proportion of metabolic syndrome–free adults from Bratislava Region, Slovakia, display an increased cardiometabolic burden

Miláček

Volkovová

Gajdoš

et al. 2021

Can. J. Physiol. Pharmacol.

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Although the dichotomous classification of metabolic syndrome (MS) enables the classification of individuals as MS-free or presenting MS, it is inconvenient for assessing cardiometabolic risk in MS-free ones. Continuous MS score allows for estimation of cardiometabolic burden even in MS-free subjects. We used the scores to estimate the proportion of MS-free subjects on high cardiometabolic risk. 876 subjects (62% females) of Central European descent, aged 20-81 years, were included. IDF criteria were employed to classify MS. Continuous scores were calculated. We used the receiver operating characteristics (ROC) analysis to estimate the cutoff value to determine the proportion of MS-free subjects on increased risk. Using the waist circumference, 38% of males and 23% of females presented MS. ROC area under the curves (90-98%) showed an acceptable performance of both scores to classify the presence of MS. Up to 18% of MS-free males and up to 10% of females displayed continuous score ≥ the relevant cut-off point. The waist-to-height ratio performed similar results. Both continuous scores were proven credible for assessing cardiometabolic risk in MS-free subjects. Clinically, this is important for earlier intervention. Despite minor differences between waist circumference and waist-to-height ratio, it would be appropriate to objectify it using reference population.

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Continuous Metabolic Syndrome Score in Children: How Useful is it?

Cited by 3 publications

References 17 publications

cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents

cMetS Based on Z-Scores as an Accurate and Efficient Scoring System to Determine Metabolic Syndrome in Spanish Adolescents

Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity

A considerable proportion of metabolic syndrome–free adults from Bratislava Region, Slovakia, display an increased cardiometabolic burden

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