Continuous micellar electrokinetic focusing of neutral species driven by ion concentration polarization

Bērziņa, Beatrise; Anand, Robbyn K.

doi:10.1039/c9lc00327d

Cited by 12 publications

(11 citation statements)

References 32 publications

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“…In this paper, the recent progress of the ICP effect in the preconcentration of microsamples in a paper-based preconcentrator is reviewed, and the basic working principle, applications, and research progress of ICP are introduced. ICP preconcentration is also widely used in microfluidic chips on other substrates, such as PDMS [97,[119][120][121][122][123][124][125][126][127][128], polycarbonate [129], glass [127,[130][131][132][133][134][135], silicon [36,[136][137][138][139], and land hydrogels [140]. In addition, studies have been conducted on ICP preconcentration driven by ion-selective osmotic membrane pressure [141], ICP preconcentration of magnetic nanoparticles and magnets [142], etc.…”

Section: Discussionmentioning

confidence: 99%

Recent advances in paper‐based preconcentrators by utilizing ion concentration polarization

et al. 2021

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One of the most cited limitations of biochemical detection is its poor sensitivity, owing to the relatively high complexity of micro-samples. Moreover, some samples cannot be easily self-replicated and their abundance cannot be increased through traditional technologies. Therefore, the preconcentration of low-abundance samples is a key requirement for microfluidic biological analysis. In recent years, the ion-concentration polarization phenomenon has aroused widespread interest in the application of microfluidic technology. In addition, paper-based materials are readily available, easy to modify, and exhibit good hydrophilicity. The study of the ion-concentration polarization preconcentration of micro-samples in paper-based microfluidic chips is of considerable significance. In this review, we discuss the development and applications of ion-concentration polarization paper-based preconcentrator in the past 5 years, with emphasis on key progresses in chip fabrication and performance optimization under different conditions. The current needs and development prospects in this field have also been discussed.

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Section: Discussionmentioning

confidence: 99%

Recent advances in paper‐based preconcentrators by utilizing ion concentration polarization

et al. 2021

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“…Low-cost membrane-based microfluidics devices have been extensively used for biosensing, sample pretreatment, analyte concentration, and pH actuation. − Under a voltage bias, an external depletion front develops across one side of a membrane and can be further propagated and controlled. , These devices can be integrated with cell culture to measure and control VEGF and calcium signaling between adjacent cells and globally over the entire tissue.…”

Section: Future Directionsmentioning

confidence: 99%

Ion-Depleting Action of Perm-Selective Membranes for Enhancing Electrical Communication and Gated Ion Channel Activity in Cell Cultures

Yadav

Senapati

2021

ACS Biomater. Sci. Eng.

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Ion-depletion action of an ion-selective membrane produces a moat channel that electrically insulates a cell colony and elevates the cell medium potential uniformly to synchronously activate and deactivate the voltage-gated ion channels of all cells. The result is robust synchronization with strong intercellular electrical communication and the discovery of ion channel deactivation that is only possible when the cells are in communication. The study suggests that the collective response of a cell colony to external stimuli is distinct from that of a single cell. Cell proliferation must hence be guided with strong intercellular communication and proper exogenous stimuli.

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“…Quite recently, we used a gated design to control the length of this depletion region in a long channel [27]. The analyte concentration features of the ion depletion front have recently been used extensively for biosensing applications [10,28‐32]).…”

Section: Membrane Microfluidics and Analyte Concentration/purificatiomentioning

confidence: 99%

Liquid biopsy technologies based on membrane microfluidics: High‐yield purification and selective quantification of biomarkers in nanocarriers

Wang

Senapati

2020

Electrophoresis

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Liquid biopsy, screening cancer non‐invasively and frequently by detecting and quantifying molecular markers in physiological fluids, would significantly improve cancer survival rate but it remains a distant goal. The key obstacles presented by the highly heterogeneous samples are rapid/high‐yield purification and precise/selective marker capture by their antibody and oligo probes. As irregular expressions of these molecular biomarkers are the key signals, quantifying only those from the cancer cells would greatly enhance the performance of the screening tests. The recent discovery that the biomarkers are carried by nanocarriers, such as exosomes, with cell‐specific membrane proteins suggests that such selection may be possible, although a new suite of fractionation and quantification technologies would need to be developed. Although under‐appreciated, membrane microfluidics has made considerable contributions to resolving these issues. We review the progress made so far, based on ion‐selective, track‐etched, and gel membranes and advanced electrophoretic and nano‐filtration designs, in this perspective and suggest future directions.

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Continuous micellar electrokinetic focusing of neutral species driven by ion concentration polarization

Abstract: Here, we demonstrate continuous electrokinetic focusing and separation of uncharged compounds by their partition into an ionic micellar phase.

Cited by 12 publications

References 32 publications

Recent advances in paper‐based preconcentrators by utilizing ion concentration polarization

Recent advances in paper‐based preconcentrators by utilizing ion concentration polarization

Ion-Depleting Action of Perm-Selective Membranes for Enhancing Electrical Communication and Gated Ion Channel Activity in Cell Cultures

Liquid biopsy technologies based on membrane microfluidics: High‐yield purification and selective quantification of biomarkers in nanocarriers

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