Continuous mixing of powder mixtures with pharmaceutical process constraints

Berthiaux, Henri; Marikh, Khadija; Gatumel, Cendrine

doi:10.1016/j.cep.2008.01.009

Cited by 73 publications

(42 citation statements)

References 9 publications

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“…In Equation (32) , is the residence time distribution at position x. is the variance at position x and can be calculated as in Equation (33) where is the variance decay rate for a continuous mixing process (33) This allows continuous mixing processes to be readily compared with batch processes. The relationship between the batch and continuous mixing efficiency can be defined in terms of the variance decay rate as in Equation (34).…”

Section: (31)mentioning

confidence: 99%

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Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

2013

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Abstract:The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models for solids-handling unit operations. Continuous processing is of particular interest in the current study because it has the potential to improve the efficiency and robustness of pharmaceutical manufacturing processes.

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Section: (31)mentioning

confidence: 99%

“…The hopper fill level can also affect feeder performance. Specifically, feeder accuracy may decrease at low hopper fill levels [33].…”

Section: Loss-in-weight Feedersmentioning

confidence: 99%

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

2013

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“…[117,118] Optimization of a mixing process often faces constraints as qualification of the characteristics of powder particles requires lengthy and multi-step operations. [116] This is particularly marked when the powder mixing involves a wide variety of excipients, in addition to drug.…”

Section: Alginate Graft Copolymersmentioning

confidence: 99%

“…The mixture quality of powder has been a common problem faced by industrialists. [116] The quality of polymer powder mixing is dependent on size, density, geometry, moisture content, surface texture and electrostatic charging of the solid particles. [117,118] Optimization of a mixing process often faces constraints as qualification of the characteristics of powder particles requires lengthy and multi-step operations.…”

Section: Alginate Graft Copolymersmentioning

confidence: 99%

Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery

Wong

2011

Journal of Pharmacy and Pharmacology

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Objectives Use of alginate graft copolymers in oral drug delivery reduces dosage form manufacture complexity with reference to mixing or coating processes. It is deemed to give constant or approximately steady weight ratio of alginate to covalently attached co-excipient in copolymers, thereby leading to controllable matrix processing and drug release. This review describes various grafting approaches and their outcome on oral drug release behaviour of alginate graft copolymeric matrices. It examines drug release modulation mechanism of alginate graft copolymers against that of co-excipients in non-grafted formulations. Key findings Drug release from alginate matrices can be modulated through using either co-excipients or graft copolymers via changing their swelling, erosion, hydrophobicity/ hydrophilicity, porosity and/or drug adsorption capacity. However, it is not known if the drug delivery performance of formulations prepared using alginate graft copolymers is superior to those incorporating graft-equivalent co-excipient physically in a dosage form without grafting but at the corresponding graft weight, owing to limited studies being available. Conclusions The value of alginate graft copolymers as the potential alternative to alginate-co-excipient physical mixture in oral drug delivery cannot be entirely defined by past and present research. Such an issue is complicated by the lack of green chemistry graft copolymer synthesis approach, high grafting process cost, complications and hazards, and the formed graft copolymers having unknown toxicity. Future research will need to address these matters to achieve a widespread commercialization and industrial application of alginate graft copolymers in oral drug delivery

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“…In one of our works [6], we examined the effect of process disturbance, such as that occurring during periods of feeding of loss-in-weight feeders. In particular, we quantified the response of the mixer to filling sequences of two critical feeders in terms of mixture homogeneity.…”

Section: Introductionmentioning

confidence: 99%

Predicting bulk powder flow dynamics in a continuous mixer operating in transitory regimes

Ammarcha

Gatumel

Dirion

et al. 2012

Advanced Powder Technology

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. This is an author-deposited version published in : http://oatao.univ-toulouse.fr/ Eprints ID : 9970 a b s t r a c tOver recent years there has been increasing interest in continuous powder mixing processes, due mainly to the development of on-line measurement techniques. However, our understanding of these processes remains limited, particularly with regard to their flow and mixing dynamics. In the present work, we study the behaviour of a pilot-scale continuous mixer during transitory regimes, in terms of hold-up weight and outflow changes. We present and discuss experimental results concerning the start-up dynamics of a Gericke GCM 500 mixer, for which a specific experimental protocol has been developed to determine the evolution of the hold-up in the mixer and the real outflow. Empirical relationships are derived so as to link hold-up weight variations with operating conditions. A simple stochastic approach, based on a non-homogeneous Markov chain, is developed to simulate the bulk particle flow and transport in the continuous mixer at a macroscopic level. Although this simple model is only based on the start-up behaviour, it provides a full description of the mixer dynamics in response to strong perturbations on the flow rate or on the rotational speed of the stirring device, such as negative or positive steps. This model is validated experimentally for a wide range of operating conditions, and constitutes a first approach to process control.

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Continuous mixing of powder mixtures with pharmaceutical process constraints

Cited by 73 publications

References 9 publications

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery

Predicting bulk powder flow dynamics in a continuous mixer operating in transitory regimes

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