Continuous monitoring devices and seizure patterns by glucose, time and lateralized seizure onset

Kinnear, Katie M.; Warner, Nicole M.; Haltiner, Alan M.; Doherty, Michael

doi:10.1016/j.ebcr.2018.03.001

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…Continuous glucose monitoring (CGM) records 5-minute tissue glucoses, that data helps manage type 1 diabetes (T1D). We studied a T1D patient with focal-onset epilepsy with CGM and RNS to identify relationships between glucose and seizure, initially by time and location of seizure, and later how IEA and seizures map over an average 24 -hs [5,8]. We found tissue glucose showed inverse relationships to IEA, with a predilection for seizure to occur when IEA were increasing.…”

Section: Introductionmentioning

confidence: 94%

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Does glucose influence multidien cycles of interictal and/or ictal activities?

Pappas

Kubsad²,

Baud

et al. 2021

Seizure

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There are multidien patterns of seizure occurrence. Predicting seizure risk may be easier with biomarker correlates to multidien patterns. We hypothesize multiday hyper or hypoglycemia contributes to seizure risk. Methods: In a type I diabetic (T1D) with focal onset epilepsy with continuous glucose monitoring (CGM) and responsive neurostimulation (RNS) devices, we studied multiday interictal activities (IEA), seizures, and glucose. Hourly CGM data was matched to hourly RNS captures of interictal and ictal activities over 33 months. RNS detection settings were unchanged. Multidien cycles were analyzed, active blocks of IEA and ictal episodes defined, and tissue glucose averages studied. Results: Average glucose was 161 mg/dl. A 40-day cycle of interictal and ictal activities occurred, though no similar glucose cycle was evident. Glucose elevations relative to patient average were associated with increases in IEA but not seizure. Frequent seizures were not associated with obvious elevations or decreases of glucose from baseline, most seizures occurred at +/-10 mg/dl of average daily glucose (i.e. 150− 170 mg/dl). Conclusion: Tissue glucose may influence IEA but may not influence multiday seizure activity or very frequent seizures. In an ambulatory T1D patient multiday hypo or hyperglycemic extremes do not appear to provoke seizure activities.

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Section: Introductionmentioning

confidence: 94%

“…Different biomarker studies focus on ictogenesis, or how might seizures be triggered? Human biomarker studies of ictogenesis need to be practical with surveillance technologies available, safe and reliable, and most importantly, somehow time linked to both long and short durations of reliable seizure documentation [4,5,8].…”

Section: Introductionmentioning

confidence: 99%

Does glucose influence multidien cycles of interictal and/or ictal activities?

Pappas

Kubsad²,

Baud

et al. 2021

Seizure

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“…We previously reported a drug-resistant focal epilepsy patient who had both a responsive neurostimulator (RNS) and continuous glucose monitoring (CGM) device for type I diabetes mellitus[1]. We found lower relative glucose and earlier morning onsets for right temporal seizures when compared to left temporal seizures.…”

mentioning

confidence: 92%

“…RNS monitoring shows various ultradian, infradian or multidien rhythms apparent in both detection and seizure events. The ictal patterns on ECoG varies by location of seizure onset [1], [2], [3].…”

mentioning

confidence: 99%

“…We evaluated 24-hour RNS detection data in our previously report and correlated hourly average tissue glucose levels over two months of consistent RNS detection parameters, insulin production and antiseizure medications. The study period did not overlap with that used in the prior report which focused on RNS detection and stimulation changes [1]. Hourly glucose was averaged from consecutive 5-minute glucose records.…”

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confidence: 99%

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