ObjectivesTo investigate if glucose levels influence seizure patterns.Materials and methodsIn a patient with RNS/NeuroPace implanted bi-temporally and type 1 diabetes mellitus, seizure event times and onset locations were matched to continuous tissue glucose.ResultsLeft focal seizure (LFS, n = 22) glucoses averaged 169 mg/dL, while right focal seizure (RFS, n = 23) glucoses averaged 131 mg/dL (p = 0.03). LFS occurred at mean time 17:02 while RFS occurred at 04:23. LFS spread to the contralateral side (n = 19) more than RFS (n = 2).ConclusionSeizure onset laterality and spread vary with glucose and time of seizure.

ObjectivesTo match responsive neurostimulator (RNS) and polysomnographic data to determine if RNS detections and stimulations correlate with measurements of sleep disordered breathing and continuous glucose measurements (CGM).Materials and methodsIn a patient with an RNS with detection/stimulation leads implanted bi-temporally detection-stimulation counts were matched by time with coinciding polysomnogram and CGM data.ResultsTemporal dispersion of RNS DSC were independent of measures of sleep apnea, hypopnea or glucose.ConclusionHippocampal nighttime responsive neurostimulation therapies did not appear to worsen measures of normal or abnormal sleep.