Continuous non-invasive monitoring to detect covert autonomic dysfunction in Parkinson's disease

Hellman, Amy; Shah, Shital; Pawlowski, Stephanie; Duda, John E.; Morley, James F.

doi:10.1016/j.parkreldis.2015.04.016

Cited by 17 publications

(8 citation statements)

References 33 publications

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“…The authors demonstrated that continuous monitoring is more sensitive than traditional monitoring for diagnosis of postural hypotension in this population. ( 9 ) Similar findings were reported by Langwieser et al, who studied the role of peripheral arterial tonometry in patients admitted to intensive care units, demonstrating that the technique has good accuracy when compared to invasive techniques, and can serve as an alternative for monitoring these patients. ( 10 ) Our study, likewise, showed no significant differences between systolic and diastolic BP readings during coronary angiography.…”

Section: Discussionsupporting

confidence: 80%

Development and clinical validation of a non-invasive, beat-to-beat blood pressure monitoring device, compared to invasive blood pressure monitoring during coronary angiography

Borges¹,

Prado²,

Santini³

et al. 2019

Einstein (São Paulo)

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Objective To develop and test a beat-to-beat blood pressure monitoring device during coronary angiography, and compare it with invasive blood pressure monitoring.Methods Twenty-eight patients with an indication for hemodynamic study were selected for this investigation, and kept in supine position. Before starting the coronary angiography, they were instructed about the use of the left radial bracelet for beat-to-beat blood pressure monitoring.Results There was a significant difference between the time required for the catheterization laboratory team to acquire the first invasive blood pressure reading and the time to obtain the first beat-to-beat reading (11.1±5.1 and 1.5±1.8, respectively; p<0.0001). The intraclass correlation coefficients (95%CI) of systolic and diastolic blood pressures were 0.897 (0.780-0.952) and 0.876 (0.734-0.942), indicating good reproducibility.Conclusion This study showed the process to develop a beat-to-beat blood pressure monitoring device. When compared to invasive blood pressure monitoring, there were no significant differences between the two methods. This technique may play a promising coadjuvant role when combined with invasive monitoring during coronary angiography procedures.

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Section: Discussionsupporting

confidence: 80%

Development and clinical validation of a non-invasive, beat-to-beat blood pressure monitoring device, compared to invasive blood pressure monitoring during coronary angiography

Borges¹,

Prado²,

Santini³

et al. 2019

Einstein (São Paulo)

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show abstract

“…A SBP of <90 mmHg is classically taken to represent critical hypotension; however, this threshold may be higher in elders (Oyetunji et al ., ). The differences in OBP we have demonstrated among the different categories of subjective memory are comparable to the BP lowering effect of antihypertensive monotherapy (Musini et al ., ) and may reflect subtle autonomic dysfunction similar to that detected by continuous BP monitoring in early Parkinson's disease (Hellman et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Sub‐clinical orthostatic hypotension is associated with greater subjective memory impairment in older adults

O’Hare

McCrory

O’Connell

et al. 2016

Int J Geriat Psychiatry

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“…For instance, in the field of sleep medicine, the use of actigraphy for sleep monitoring may be used to supplant more traditional methods such as polysomnography because of its validity, lower cost, and ability to evaluate individuals in their homes during a longer period of time . Advanced wearable technologies can also precisely monitor skin conductance, respiratory rate, blood pressure, and oximetry and provide surface EMG, electrocardiography, and electroencephalography tracings . Furthermore, the ability to collect TOMs using smart devices (mobile phones, tablets, and smart watches) provides additional opportunities to collect and analyze numerous clinically relevant parameters (eg, posture, balance, dexterity, voice and speech patterns, facial expression, eye tracking, medication, and exercise compliance and adherence) and develop communication portals to improve patient engagement and self‐management.…”

Section: Definitions and Objectivesmentioning

confidence: 99%

Technology in Parkinson's disease: Challenges and opportunities

et al. 2016

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The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capturing of more and previously inaccessible phenomena in Parkinson disease (PD). However, more information has not translated into greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include non-compatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (in particular among vulnerable elderly patients), and the gap between the “big data” acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms enabling multi-channel data capture, sensitive to the broad range of motor and non-motor problems that characterize PD, and adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to: 1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones; 2) enhance tailoring of symptomatic therapy; 3) improve subgroup targeting of patients for future testing of disease modifying treatments; and 4) identify objective biomarkers to improve longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the Task Force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and quality of life of individuals with PD.

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Continuous non-invasive monitoring to detect covert autonomic dysfunction in Parkinson's disease

Cited by 17 publications

References 33 publications

Development and clinical validation of a non-invasive, beat-to-beat blood pressure monitoring device, compared to invasive blood pressure monitoring during coronary angiography

Development and clinical validation of a non-invasive, beat-to-beat blood pressure monitoring device, compared to invasive blood pressure monitoring during coronary angiography

Sub‐clinical orthostatic hypotension is associated with greater subjective memory impairment in older adults

Technology in Parkinson's disease: Challenges and opportunities

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