Continuous quantitative measurement of the proximal airway dimensions and lung density on four-dimensional dynamic-ventilation CT in smokers

Yamashiro, Tsuneo; Moriya, Hideshige; Tsubakimoto, Maho; Matsuoka, Shin; Murayama, Sadayuki

doi:10.2147/copd.s100658

Cited by 33 publications

(32 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These hypotheses should be evaluated in future studies.Although the majority (81%) of enrolled patients in our study were current or ex-smokers, we did not find a significant correlation between LAA% and pre-or poststenting spirometric values. Compared with previous publications analyzing COPD patients and smokers that demonstrated significant correlations between LAA% and spirometric values[25] [26], the discordant observations of our study may suggest that, in patients with malignant tracheal stenosis, the severity of the tracheal stenosis is the most important factor for reduced airflow limitation, and the extent of emphysema may be an inferior, lesser factor. This may be partially supported by the observation that the correlation coefficients between LAA% and the spirometric values increase after stenting, although the correlations are not significant.…”

contrasting

confidence: 70%

Tracheal Stenosis Caused by Thoracic Malignancy: Correlation between CT-Based Tracheal Measurement and Spirometric Values before and after Tracheal Stenting

Azagami¹,

Yamashiro²,

Handa³

et al. 2017

OJMI

Self Cite

View full text Add to dashboard Cite

Background: The correlation between computed tomography (CT)-based tracheal size and spirometry values is unknown in patients with tracheal stenosis by thoracic malignancy, which is often treated by tracheal stenting. Objectives: To evaluate the correlation between the tracheal cross-sectional area (CSA) and spirometric values before and after tracheal stenting, and to confirm that greater improvement in tracheal CSA leads to a larger improvement in spirometry values. Methods: A total of 32 patients with malignant tracheal stenosis underwent tracheal stenting. Before (n = 32) and after (n = 27) treatment, patients underwent chest CT, measuring mean and minimum tracheal CSA values, and spirometry. The correlation between tracheal CSA and each spirometric value was evaluated using Spearman rank correlation analysis. Differences in the pre-and posttreatment tracheal CSA and spirometric values were evaluated using the Wilcoxon matched-pairs test. Results: Significant improvement in the minimum tracheal CSA and in spirometric values was observed after stenting (P < 0.001). Pretreatment analysis revealed significant correlations between the minimum tracheal CSA and various spirometric values (P < 0.01), but posttreatment analysis showed weak or insignificant correlations. The increase in the minimum tracheal CSA obtained by stenting was significantly correlated with improvement in multiple spirometric values (P < 0.05). Conclusions: The tracheal size measured on chest CT correlates with patients' spirometric values, particularly at the prestenting examination,

show abstract

contrasting

confidence: 70%

Tracheal Stenosis Caused by Thoracic Malignancy: Correlation between CT-Based Tracheal Measurement and Spirometric Values before and after Tracheal Stenting

Azagami¹,

Yamashiro²,

Handa³

et al. 2017

OJMI

Self Cite

View full text Add to dashboard Cite

show abstract

“…Using the wide volume mode (non-helical mode), dynamic scanning was performed at a fixed point without bed movement, resulting in fluoroscopic images of 160 mm in length 19,20. Scanning field of view (FOV) was selected from two settings based on patient body habitus: 320 (medium, n=14) or 400 mm (large, n=18).…”

Section: Methodsmentioning

confidence: 99%

Asynchrony in respiratory movements between the pulmonary lobes in patients with COPD: continuous measurement of lung density by 4-dimensional dynamic-ventilation CT

Yamashiro

Moriya

Matsuoka

et al. 2017

COPD

Self Cite

View full text Add to dashboard Cite

PurposeFour-dimensional dynamic-ventilation CT imaging demonstrates continuous movement of the lung. The aim of this study was to assess the correlation between interlobar synchrony in lung density and spirometric values in COPD patients and smokers, by measuring the continuous changes in lung density during respiration on the dynamic-ventilation CT.Materials and methodsThirty-two smokers, including ten with COPD, underwent dynamic-ventilation CT during free breathing. CT data were continuously reconstructed every 0.5 sec. Mean lung density (MLD) of the five lobes (right upper [RU], right middle [RM], right lower [RL], left upper [LU], and left lower [LL]) was continuously measured by commercially available software using a fixed volume of volume of interest which was placed and tracked on a single designated point in each lobe. Concordance between the MLD time curves of six pairs of lung lobes (RU-RL, RU-RM, RM-RL, LU-LL, RU-LU, and RL-LL lobes) was expressed by cross-correlation coefficients. The relationship between these cross-correlation coefficients and the forced expiratory volume in one second/forced vital capacity (FEV1.0/FVC) values was assessed by Spearman rank correlation analysis.ResultsIn all six pairs of the pulmonary lobes, the cross-correlation coefficients of the two MLD curves were significantly positively correlated with FEV1.0/FVC (ρ =0.60–0.73, P<0.001). The mean value of the six coefficients strongly correlated with FEV1.0/FVC (ρ =0.80, P<0.0001).ConclusionThe synchrony of respiratory movements between the pulmonary lobes is limited or lost in patients with more severe airflow limitation.

show abstract

“…Its performance has been improved by single-photon emission computed tomography (SPECT). 1,2 Recently, four-dimensional computed tomography (4DCT) [3][4][5][6][7] and dynamic magnetic resonance imaging (MRI) 8,9 have also been proposed and demonstrated promising results. These novel imaging techniques are expected to increase the diagnostic performance in the field of respiratory medicine and surgery.…”

Section: Introductionmentioning

confidence: 99%

Comparison of dynamic flat‐panel detector‐based chest radiography with nuclear medicine ventilation‐perfusion imaging for the evaluation of pulmonary function: A clinical validation study

et al. 2020

View full text Add to dashboard Cite

Purpose: Dynamic chest radiography (DCR) is a flat-panel detector (FPD)-based functional lung imaging technique capable of measuring temporal changes in radiographic lung density due to ventilation and perfusion. The aim of this study was to determine the diagnostic performance of DCR in the evaluation of pulmonary function based on changes in radiographic lung density compared to nuclear medicine lung scans. Methods: This study included 53 patients with pulmonary disease who underwent DCR and nuclear medicine imaging at our institution. Dynamic chest radiography was conducted using a dynamic FPD system to obtain sequential chest radiographs during one breathing cycle. The maximum change in the average pixel value (Δ max) was measured, and the percentage ofΔ max in each lung region, calculated relative to the sum of all lung regions (Δ max %), was calculated for each factor (ventilation and perfusion). The Δ max % was compared with the accumulation of radioactive agents (radioactive agents%) on ventilation and perfusion scans in each lung and lung region using correlation coefficients and scatter plots. The ratio of ventilation to perfusion Δ max % was calculated and compared with nuclear medicine ventilation-perfusion (V/Q) findings in terms of sensitivity and specificity for V/Q mismatch in each lung region. Results: There was a high correlation between Δ max % and radioactive agents% for each lung (Ventilation: r = 0.81, perfusion: r = 0.87). However, correlation coefficients were lower (0.37 to 0.80) when comparing individual lung regions, with the upper lung regions showing the lowest correlation coefficients. The sensitivity and specificity of DCR for V/Q mismatch were 63.3% (19/30) and 60.1% (173/288), respectively. Motion artifacts occasionally increased Δ max %, resulting in false negatives. Conclusions: Ventilation and perfusion Δ max % correlated reasonably with radioactive agents% on ventilation and perfusion scans. Although the regional correlations were lower and the detection performance for V/Q mismatch was not enough for clinical use at the moment, these results suggest the potential for DCR to be used as a functional imaging modality that can be performed without the use of radioactive contrast agents. Further technical improvement is required for the implementation of DCR-based V/Q studies.

show abstract

Continuous quantitative measurement of the proximal airway dimensions and lung density on four-dimensional dynamic-ventilation CT in smokers

Cited by 33 publications

References 40 publications

Tracheal Stenosis Caused by Thoracic Malignancy: Correlation between CT-Based Tracheal Measurement and Spirometric Values before and after Tracheal Stenting

Tracheal Stenosis Caused by Thoracic Malignancy: Correlation between CT-Based Tracheal Measurement and Spirometric Values before and after Tracheal Stenting

Asynchrony in respiratory movements between the pulmonary lobes in patients with COPD: continuous measurement of lung density by 4-dimensional dynamic-ventilation CT

Comparison of dynamic flat‐panel detector‐based chest radiography with nuclear medicine ventilation‐perfusion imaging for the evaluation of pulmonary function: A clinical validation study

Contact Info

Product

Resources

About