Continuous “Snowing” Thermotherapeutic Graphene

Sun, Yangyong; Chen, Zengzhen; Gong, Hongli; Li, Xueqiao; Gao, Zhenfei; Xu, Shuo; Han, Xiaodong; Han, Bing; Meng, Xianwei; Zhang, Jin

doi:10.1002/adma.202002024

Cited by 26 publications

(27 citation statements)

References 35 publications

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“…An increase of ∼250% of the compressive strength of PDMS was also achieved at the same mass fraction. Sun et al 22 realized the increase in Young's modulus and flexural modulus of high-density polyethylene by ∼22.7% and ∼43.3% with the addition of 1% in mass fraction of graphene obtained by the PEMIS process (Figure 10j), the similar effect was also realized by Ahmad et al 95…”

Section: Reinforcementsupporting

confidence: 65%

“…It is obvious that the obtained graphene is deposited on the wall of the glass reactor. 65 Sun et al 22 developed a "pulse-etched" microwaveinduced "snowing" (PEMIS) process for continuously growth of graphene in the gas phase using CH 4 . By introduction of O 2 in a pulsed manner, the interference of wrapped graphene remaining on the inner wall of the reaction chamber can be greatly avoided.…”

Section: Surface Wave-induced Microwave Plasmamentioning

confidence: 99%

“…Numerous studies have shown that prepared graphene is of high crystallinity and purity. 22,73 Future work must focus on the scalable preparation of graphene demanded by industry. In the meanwhile, the adjustment of various parameters during the graphene growth process also requires more detailed work to achieve controlled preparation.…”

Section: Surface Wave-induced Microwave Plasmamentioning

confidence: 99%

“…The gas phase-prepared free-standing graphene, especially synthesized by atmospheric plasma, usually exhibits characteristics of high quality, low oxygen content, high purity, small size, and few layers. Based on the intrinsic characteristics of graphene, fields such as mechanical sensors, 21 energy storage, 89 support film in TEM, 90 inkjet printing, 21 reinforcements, 27 and hyperthermia 22 have been explored.…”

Section: Applications Of High-quality Free-standing Graphenementioning

confidence: 99%

“…Afterward, by loading liposoluble drugs such as Apatinib onto graphene followed by injection into mice, a combination of microwave thermal therapy and chemotherapy was achieved with a tumor treatment rate as high as 86.7%. 22…”

Section: Hyperthermiamentioning

confidence: 99%

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Strategies for Scalable Gas-Phase Preparation of Free-Standing Graphene

Sun

Zhang

2021

CCS Chem

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The preparation of graphene with high quality serves as a prerequisite for its usage. Traditional methods of graphene production, represented by liquid-phase exfoliation and chemical vapor deposition, either sacrifice the quality and purity of graphene or are limited by the substrate and catalyst. Developing simple and scalable preparation methods of high-quality and high-purity graphene remains a big challenge. Herein, we have reviewed the gas-phase methods including carbonization, combustion, arc discharge, and atmospheric plasma for scalable preparation of free-standing graphene, which are catalyst-, substrate-, solvent-free, and without the need for complex post-treatment methods. The obtained graphene exhibits characteristics of high quality and high purity. Moreover, applications of free-standing graphene were also summarized. Finally, perspectives on opportunities and challenges of free-standing graphene have been discussed.

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Section: Reinforcementsupporting

confidence: 65%

Section: Surface Wave-induced Microwave Plasmamentioning

confidence: 99%

Section: Surface Wave-induced Microwave Plasmamentioning

confidence: 99%

Section: Applications Of High-quality Free-standing Graphenementioning

confidence: 99%

Section: Hyperthermiamentioning

confidence: 99%

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Strategies for Scalable Gas-Phase Preparation of Free-Standing Graphene

Sun

Zhang

2021

CCS Chem

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Biomimetic MOF‐Based Nano‐Immunoactivator via Disruption of Ion Homeostasis for Strengthened Tumor Microwave‐Immunotherapy

Chen,

Guo,

Tan

et al. 2024

Adv Funct Materials

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Immunogenic cell death (ICD) is a promising strategy for anticancer immunity by inducing antigen‐presenting cell maturation. However, the traditional ICD inducers, such as chemotherapeutic agents, have largely hampered their application by severe side effects and low tumor selectivity. The changes intra/extracellular ion concentrations affect the growth and metastasis of tumor cells. Interference with ion homeostasis can induce tumor cell death and elicit immune responses. Here, a biomimetic Ga‐based metal–organic framework (MOF) coated with red blood cell–platelet fusion membrane (RPM), that is, 5‐fluorouracil@GaMOF@RPM (5‐FUGR) nano‐immunoactivator, is reported as a highly efficient ICD inducer for enhanced microwave (MW)‐immunotherapy. Following intravenous administration, 5‐FUGR accumulates to tumor site via RPM biomimetic modification‐mediated long circulation and active targeting. The structure of 5‐FUGR undergoes degradation and releases Ga3+. MW combined with high concentrations of Ga3+ disrupts intracellular ion homeostasis, which leads to severe oxidative stress and intracellular Ca2+ retention to promote apoptosis of tumor cells. More importantly, 5‐FUGR combined with MW not only completely eradicates 4T1 primary tumors, but also induces efficient ICD, immune initiation, and memory effects to inhibit metastatic and recurrence of the tumor. Thus, 5‐FUGR, as a strong ICD inducer, provides new insights into achieving tumor immunity in combination with other therapies.

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Production, Characterization, and Application of Hydrophobin‐Based IR780 Nanoparticles for Targeted Photothermal Cancer Therapy and Advanced Near‐Infrared Imaging

Yang,

Wang,

Huang

et al. 2024

Adv Healthcare Materials

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As a promising approach for breast cancer treatment, photothermal therapy (PTT) features high spatial selectivity, noninvasiveness, and minimal drug resistance. IR780 (a near‐infrared fluorescent dye) serves as an effective photosensitizer in PTT cancer therapy. However, the clinical application of IR780 in PTT has been hindered by its poor water solubility and unstable photostability. In this study, a genetically engineered dual‐functional fusion protein tLyP‐1‐MGF6 is successfully constructed and expressed, which presents a novel use of hydrophobin MGF6 for its amphiphilicity combined with the tumor‐penetrating peptide tLyP‐1 to create an innovative carrier for IR780. These results show this fusion protein serving as a biodegradable and biocompatible carrier, significantly improves the water solubility of IR780 when formulated into nanoparticles. These studies demonstrate that the IR780@tLyP‐1‐MGF6 nanoparticles significantly enhance tumor targeting and photothermal therapeutic efficacy in comparison with control in vitro and in vivo. These advancements highlight the potential of the unique combination hydrophobin‐based IR780 delivery system as a multifunctional nanoplatform for integrated imaging and targeted photothermal treatment of breast cancer.

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Continuous “Snowing” Thermotherapeutic Graphene

Cited by 26 publications

References 35 publications

Strategies for Scalable Gas-Phase Preparation of Free-Standing Graphene

Strategies for Scalable Gas-Phase Preparation of Free-Standing Graphene

Biomimetic MOF‐Based Nano‐Immunoactivator via Disruption of Ion Homeostasis for Strengthened Tumor Microwave‐Immunotherapy

Production, Characterization, and Application of Hydrophobin‐Based IR780 Nanoparticles for Targeted Photothermal Cancer Therapy and Advanced Near‐Infrared Imaging

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