Continuous theta burst stimulation inhibits the bilateral hemispheres

Hu, Ruiping; Zhu, Yulian; Tang, Xinwei; Du, Xiaoxia; Zhang, Hui; Liu, Qiaoyun; Wu, Junfa; Fan, Shunjuan; Hao, Youguo; Wu, Yi

doi:10.1016/j.neulet.2017.07.018

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…Matsuta et al ( 2022 ) further add that cTBS to the left motor representation of the abductor pollicis brevis (APB) had no consequences on resting state network activity, including the default mode network (DMN) and primary motor network. Regarding resting-state functional connectivity ([rs]FC) however, cTBS to the M1 hand (Hu et al 2017 ) and suprahyoid muscle (Ruan et al 2017 , 2019 ) representations, as well as the SMA (Ji et al 2017 , 2020 ) resulted in reduced network rsFC. Timing of post-stimulation follow-ups might, however, be a critical factor.…”

Section: Discussionmentioning

confidence: 99%

“…These studies must be considered with caution as neurodevelopmental factors associated with this population might confound results. Further, while Hu et al ( 2017 ) reported outcomes stratified by biological sex, statistical comparisons were not presented. None of the reviewed literature investigated genetic or epigenetic effects.…”

Section: Discussionmentioning

confidence: 99%

“…More systematic reporting in this regard is paramount. This inconsistency is likely to affect observed outcomes, as some reported a strengthening of the TBS effects over time (Tang et al 2019 ; Gratton et al 2013 ), while other report shifts in the direction (Heinen et al 2017 ; Hu et al 2017 ; Ji et al 2020 ) or location (Ji et al 2020 ) of response, or a combination of these outcomes (Singh et al 2020 ). Further, the duration of time that the TBS effects remain appears site/network dependant.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)

Kirkovski

Donaldson

et al. 2023

Brain Struct Funct

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Theta burst stimulation (TBS) is associated with the modulation of a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and task-based functional magnetic resonance imaging (fMRI) outcomes post-TBS in healthy human adults. Fifty studies that applied either continuous—or intermittent—(c/i) TBS, and adopted a pretest–posttest or sham-controlled design, were included. For resting-state outcomes following stimulation applied to motor, temporal, parietal, occipital, or cerebellar regions, functional connectivity generally decreased in response to cTBS and increased in response to iTBS, though there were some exceptions to this pattern of response. These findings are mostly consistent with the assumed long-term depression (LTD)/long-term potentiation (LTP)-like plasticity effects of cTBS and iTBS, respectively. Task-related outcomes following TBS were more variable. TBS applied to the prefrontal cortex, irrespective of task or state, also produced more variable responses, with no consistent patterns emerging. Individual participant and methodological factors are likely to contribute to the variability in responses to TBS. Future studies assessing the effects of TBS via fMRI must account for factors known to affect the TBS outcomes, both at the level of individual participants and of research methodology.

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