Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant

Birkholz, M.; Glogener, Paul; Glös, Franziska; Basmer, Thomas; Theuer, Lorenz

doi:10.3390/mi7100183

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…However, over time, these materials tend to allow water permeation. Titanium housing, commonly used in various electronic medical implants such as electrical simulators, was initially chosen as the MICS protocol is known to pass through a thin layer of this material 45 . However, our experience in working with titanium is that it is time-consuming, expensive, and requires specific equipment.…”

Section: Discussionmentioning

confidence: 99%

From wires to waves, a novel sensor system for in vivo pressure monitoring

Wright,

Züchner,

Annavini

et al. 2024

Sci Rep

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Pressure monitoring in various organs of the body is essential for appropriate diagnostic and therapeutic purposes. In almost all situations, monitoring is performed in a hospital setting. Technological advances not only promise to improve clinical pressure monitoring systems, but also engage toward the development of fully implantable systems in ambulatory patients. Such systems would not only provide longitudinal time monitoring to healthcare personnel, but also to the patient who could adjust their way-of-life in response to the measurements. In the past years, we have developed a new type of piezoresistive pressure sensor system. Different bench tests have demonstrated that it delivers precise and reliable pressure measurements in real-time. The potential of this system was confirmed by a continuous recording in a patient that lasted for almost a day. In the present study, we further characterized the functionality of this sensor system by conducting in vivo implantation experiments in nine female farm pigs. To get a step closer to a fully implantable system, we also adapted two different wireless communication solutions to the sensor system. The communication protocols are based on MICS (Medical Implant Communication System) and BLE (Bluetooth Low Energy) communication. As a proof-of-concept, implantation experiments in nine female pigs demonstrated the functionality of both systems, with a notable technical superiority of the BLE.

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Section: Discussionmentioning

confidence: 99%

From wires to waves, a novel sensor system for in vivo pressure monitoring

Wright,

Züchner,

Annavini

et al. 2024

Sci Rep

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show abstract

“…Therefore, the selection of ASs will dictate the appropriate type of biosensor used. For example, a metal-oxide sensor, currently used in an IEMD for measuring signals generated by glucose (sugar), could be placed in the interstitial tissue to measure glucose concentration [34], [35].…”

Section: The Mocobo Receivermentioning

confidence: 99%

Novel Molecular Signaling Method and System for Molecular Communication in Human Body

AbdulAziz

Liang

2020

IEEE Access

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Recently, Molecular Communication (MC) has been recognized as an enabling technology for nanonetworks [1] where MC is envisioned to enable nanorobots to achieve sophisticated and complex tasks in the human body for promising medical applications. Many MC methods that can be applied in the human body have been proposed and modeled in the literature. In this paper, we propose a new method and system for Molecular Communication in the Body, denoted MoSiMe and MoCoBo, respectively. The method takes advantage of how the absorption, distribution, metabolization, and excretion (ADME) bodily processes affects drugs, referred to as Pharmacokinetics (PK) in pharmacology, to enable MC between any points of the human body regardless of their distance even if they are in different parts of the body and separated by tissues and fluids. The architecture, design and components of the MoCoBo system and MoSiMe method are described and different transmitter designs, including a novel passive transmitter design for the first time in telecommunications, are introduced. An analytical model for the body channel is derived and validated with respect to existing human and animal tests. The model captures the ADME bodily processes that affect the kinetics of substances administered to the body. Additionally, an experimental MoCoBo proof of concept platform, capable of sending and receiving a stream of bits between a transmitter and a receiver, is built and validated against clinical trials, animal tests and analytical models. The introduced platform can also be utilized to test modulation techniques and designs for new MoCoBo transmitters and receivers. INDEX TERMS Communication systems, molecular communication in body, molecular communication via ADME, MoCoBo experimental platform, MoSiMe, Nano communication.

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Nanostructured Biomaterials for In Vivo Biosensors

Malhotra¹,

Ali²

2018

Nanomaterials for Biosensors

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Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant

Cited by 5 publications

References 21 publications

From wires to waves, a novel sensor system for in vivo pressure monitoring

From wires to waves, a novel sensor system for in vivo pressure monitoring

Novel Molecular Signaling Method and System for Molecular Communication in Human Body

Nanostructured Biomaterials for In Vivo Biosensors

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