Continuum Mixture Models of Biological Growth and Remodeling: Past Successes and Future Opportunities

Ateshian, Gerard A.; Humphrey, Jay D.

doi:10.1146/annurev-bioeng-071910-124726

Cited by 65 publications

(42 citation statements)

References 84 publications

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“…Mechanical forces such as stretching and contraction direct a variety of cellular processes: epithelial sheets are stretched and deformed during embryonic development [1], muscle contraction contributes to the remodeling of connective tissue [2], and the vascular endothelia adjusts to changes in blood pressure [3]. To minimize mechanical damage to cells and to maintain tissue homeostasis, mechanical forces generated outside the cell must be balanced with forces inside the cell (Figure 1A) [4].…”

Section: Overview Of Mechanotransductionmentioning

confidence: 99%

LIM proteins in actin cytoskeleton mechanoresponse

Smith

Hoffman

Beckerle

2014

Trends in Cell Biology

111

112

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The actin cytoskeleton assembles into branched networks or bundles to generate mechanical force for critical cellular processes such as establishment of polarity, adhesion, and migration. Stress fibers are contractile, actomyosin structures that physically couple to the extracellular matrix through integrin-based focal adhesions, thereby transmitting force into and across the cell. Recently, LIM domain proteins have been implicated in mediating this cytoskeletal mechanotransduction. Among the more well studied LIM domain adapter proteins is zyxin, a dynamic component of both focal adhesions and stress fibers. Here, we discuss recent research detailing the mechanisms by which stress fibers adjust their structure and composition to balance mechanical forces, and suggest ways zyxin and other LIM domain proteins mediate mechanoresponse.

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Section: Overview Of Mechanotransductionmentioning

confidence: 99%

LIM proteins in actin cytoskeleton mechanoresponse

Smith

Hoffman

Beckerle

2014

Trends in Cell Biology

111

112

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“…It is almost superfluous to remind ourselves that cellular mutations and interactions are essential in that case. Humphrey (2003) has reviewed results in biomechanics and has indicated trends on the matter (see also Athesian & Humphrey, 2012;Nedjar, 2011). Nontrivial theoretical issues are involved already at the level of the geometric description of the relevant processes.…”

Section: Micro-to-macro Interactionsmentioning

confidence: 99%

Mechanics of Material Mutations

Mariano

2014

Advances in Applied Mechanics

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“…In additional to guiding scaffold development, these properties could also prove to be of value to groups interested in the development of skeletal muscle computational models including recent growth and remodeling approaches that utilize tissue ECM parameters during model development and validation [35]. The data could also be used to help guide the development of physical models.…”

Section: Discussionmentioning

confidence: 99%

The characterization of decellularized human skeletal muscle as a blueprint for mimetic scaffolds

Wilson

Terlouw

Roberts

et al. 2016

J Mater Sci: Mater Med

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The use of decellularized skeletal muscle (DSM) as a cell substrate and scaffold for the repair of volumetric muscle loss injuries has shown therapeutic promise. The performance of DSM materials motivated our interest in exploring the chemical and physical properties of this promising material. We suggest that these properties could serve as a blueprint for the development of next generation engineered materials with DSM mimetic properties. In this study, whole human lower limb rectus femoris (n=10) and upper limb supraspinatus muscle samples (n=10) were collected from both male and female tissue donors. Skeletal muscle samples were decellularized and nine property values, capturing key compositional, architectural, and mechanical properties, were measured and statistically analyzed. Mean values for each property were determined across muscle types and genders. Additionally, the influence of muscle type (upper versus lower limb) and donor gender (male versus female) on each of the DSM material properties was examined. The data suggests that DSM materials prepared from lower limb rectus femoris samples have an increased modulus and contain a higher collagen content then upper limb supraspinatus muscles. Specifically, lower limb rectus femoris DSM material modulus and collagen content was approximately twice that of lower limb supraspinatus DSM samples. While muscle type did show some influence on material properties, we did not find significant trends related to gender. The material properties reported herein may be used as a blueprint for the data-driven design of next generation engineered scaffolds with muscle mimetic properties, as well as inputs for computational and physical models of skeletal muscle.

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Continuum Mixture Models of Biological Growth and Remodeling: Past Successes and Future Opportunities

Cited by 65 publications

References 84 publications

LIM proteins in actin cytoskeleton mechanoresponse

LIM proteins in actin cytoskeleton mechanoresponse

Mechanics of Material Mutations

The characterization of decellularized human skeletal muscle as a blueprint for mimetic scaffolds

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