Contração de feridas após cobertura com substitutos temporários de pele

Coelho, Mariana de Freitas; Rezende, Cleuza Maria de Faria; Tenório, Ana Paula Monteiro

doi:10.1590/s0103-84781999000200018

Cited by 8 publications

(10 citation statements)

References 14 publications

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“…The burn healing occurs by second intention, which is a slow process with high risk of infection, producing scar retraction, which depending on the area of injury can cause extensive scarring and consequently high cost in treatment [ 31 ]. The contraction of skin lesions occurs centripetally fromthe injury edges being caused by the action of myofibroblasts present at the site.…”

Section: Resultsmentioning

confidence: 99%

Development of Animal Model for Studying Deep Second-Degree Thermal Burns

Pereira

Lima-Ribeiro

Pontes-Filho

et al. 2012

Journal of Biomedicine and Biotechnology

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Thermal lesions were produced in 12 male Wistar rats, positioning a massive aluminum bar 10 mm in diameter (51 g), preheated to 99°C ± 2°C/10 min. on the back of each animal for 15 sec. After 7, 14, 21, and 28 days, animals were euthanized. The edema intensity was mild, with no bubble and formation of a thick and dry crust from the 3rd day. The percentage of tissue shrinkage at 28 days was 66.67 ± 1.66%. There was no sign of infection, bleeding, or secretion. Within 28 days reepithelialization was incomplete, with fibroblastic proliferation and moderate fibrosis and presence of modeled dense collagen fibers. It is concluded that the model established is applicable in obtaining deep second-degree thermal burns in order to evaluate the healing action of therapeutic agents of topical use.

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Section: Resultsmentioning

confidence: 99%

Development of Animal Model for Studying Deep Second-Degree Thermal Burns

Pereira

Lima-Ribeiro

Pontes-Filho

et al. 2012

Journal of Biomedicine and Biotechnology

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“…In both groups, there was a gradual reduction in the wound areas from the 7 th DPO. COELHO et al, (1999) and MARTINS et al (2013) also observed an increase in the areas of the wounds in the initial phase of the healing process, caused by the shrinkage of the rim of the lesions due to the action of the lines of tension (Langer Lines). In making the square wounds, the skin was incised in both directions, longitudinal and transversal, determining the increase in area due to stretching caused by the transverse incisions according to Langer's lines (ALGOWER, 1977apud COELHO et al, 1999.…”

Section: Lucas Et Almentioning

confidence: 93%

Copaiba oil in experimental wound healing in horses

et al. 2017

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The aim of this study was to evaluate the effects of 10% copaiba oil in experimentally induced wounds in horses. Four wounds were made in the lumbar and metacarpal regions of eight adult horses. In the treatment group, the wounds received 10% copaiba oil and in the control group 0.9% sodium chloride, in the daily dressing for 21 days. The wounds were evaluated three, 7, 14, and 21 days postoperatively. No significant differences were observed between the groups. The mean lumbar wound contraction rates were 80.54% and 69.64%, for the control and treated groups, respectively. For the wounds in the metacarpal region, these averages were 44.15% and 52.48%, respectively. Under the experimental conditions of the present study, it is concluded that 10% copaiba oil has beneficial in wound healing in the equine species and suggest that copaiba oil can be used as a therapeutic possibility in equine wound therapy.

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“…Wound contraction is frequently assessed in these experiments because it allows for a better understanding of the healing process evolution and the maturation of the scar, which represent myofibroblast activity, and the buildup and maturation of collagen fibers (COELHO et al, 1999). Morphometric evaluation assays are employed to measure the diameter of the lesion, in order to establish a comparison of the initial measurement and subsequent results throughout the healing process (LIMA et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…This process is favored where the skin is looser, such as the abdomen and trunk (COELHO; REZENDE, TENÓRIO, 1999). Wound contraction is one of the most important aspects when assessing the healing process of open skin wounds (MEDRANO, 2010), and several methods and tools are used to measure the evolution of this phenomenon in wound healing assays (FALCÃO et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Comparing open wound measuring methods popularly used in experimental studies

Fernandes

Lopes

Capella

et al. 2015

Braz. J. Vet. Res. Anim. Sci.

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Tissue repair is a response reaction to lesions and aggressions that constitutes a dynamic process to maintain the integrity of the organism. Wound healing experiments have used several approaches in order to assess and compare treatment methods, and these discrepancies hamper comparisons among assays. This study assessed three different methods of wound measurement commonly used in healing assays: clock method, graph paper method, and computer-assisted image analysis. We used 30 Wistar rats, kept in appropriate conditions for animal well-being. After anesthesia, and using an eight-millimeter punch, two lesions were made in the back region of each rat. The wounds were assessed on days four, seven, and 14 after infliction. At four days, all methods generated similar results. By day seven, the clock method had lost precision, likely due to wound shrinkage, and yielded greater means compared to the other two methods. On the last assessment, the computer-assisted method appeared to have more precise results, with the other two generating statistically higher means. Computer-assisted image analysis seems to have maintained wound measuring precision throughout this experiment, even when faced with small lesions. Considering these results, the authors recommend the use of computer-assisted measurements in future experiments. Keywords:Healing. Wound contraction. Granulation tissue. Animal experimentation. ResumoO reparo tecidual surge em resposta às lesões e constitui-se de um processo dinâmico para manutenção da integridade do organismo. Nos estudos sobre cicatrização de feridas, tem se utilizado várias técnicas buscando-se uma avaliação da eficácia de meios de tratamento local. Sendo assim, o presente trabalho objetivou comparar três métodos de avaliação experimental de áreas de feridas, sendo eles: o método do relógio, papel milimetrado e avaliação computadorizada. Para realização do experimento, foram utilizados 30 ratos Wistar em condições de bem-estar. Após realizada a anestesia, foram confeccionadas duas lesões no dorso de cada animal com punch de 8 mm, sendo as feridas avaliadas após quatro, sete e 14 dias de tratamento. Observou-se que aos quatro dias de tratamento, todos os métodos apresentaram o mesmo desempenho, enquanto aos sete e 14 dias, o método do relógio, apresentou maior média de área, perdendo precisão, e aos 14 dias, a avaliação computadorizada apresentou resultados mais precisos em relação a ambos os outros métodos. Concluiu-se que a avaliação computadorizada através de software de áreas de feridas cutâneas apresenta resultados mais precisos em relação aos métodos do relógio e papel milimetrado, principalmente em lesões menores. Palavras-chave:Cicatrização. Contração da ferida. Tecido de granulação. Experimentação animal.

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Contração de feridas após cobertura com substitutos temporários de pele

Cited by 8 publications

References 14 publications

Development of Animal Model for Studying Deep Second-Degree Thermal Burns

Development of Animal Model for Studying Deep Second-Degree Thermal Burns

Copaiba oil in experimental wound healing in horses

Comparing open wound measuring methods popularly used in experimental studies

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