Contramid®: High-Amylose Starch for Controlled Drug Delivery

Ravenelle, François; Rahmouni, Miloud

doi:10.1021/bk-2006-0934.ch004

Cited by 16 publications

(17 citation statements)

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“…These effects may be attributed to differences in the controlled-release technologies employed, specifically the solubilities of the inactive ingredients in alcohol. The Tridural™ formulation comprises core and coat matrices combined to generate a compression coated tablet (Rahmouni et al, 2006). The core blend is predominantly a mixture of Contramid ® -modified pregelatinized starch and tramadol, designed to provide a sustained release of the active ingredient and, thereby, 24-h efficacy.…”

Section: Discussionmentioning

confidence: 99%

Influence of Alcohol on the Release of Tramadol from 24-h Controlled-Release Formulations During In Vitro Dissolution Experiments

Traynor

Brown

Pannala

et al. 2008

Drug Development and Industrial Pharmacy

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Section: Discussionmentioning

confidence: 99%

Influence of Alcohol on the Release of Tramadol from 24-h Controlled-Release Formulations During In Vitro Dissolution Experiments

Traynor

Brown

Pannala

et al. 2008

Drug Development and Industrial Pharmacy

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show abstract

“…The swelling observed upon immersion of the tablet in water is limited and anisotropic Thérien-Aubin & Zhu, 2006;Thérien-Aubin et al, 2005. The limited swelling, leading to the shape retention of the tablet and the prevention of tablet dissolution or erosion, is caused by the reorganization of the hydrated starch chains (Le Bail et al, 1999;Ravenelle & Rahmouni, 2006). The reorganization of the starch chains was evidenced by 13 C NMR spectroscopy as discussed in the precedent section.…”

Section: Swelling Of Chas Tabletsmentioning

confidence: 99%

“…The instability is often associated with the retrogradation of the starch, both the crosslinking and the functionalization will limit the reorganization of the starch chains leading to retrogradation. Crosslinks hinder the movement of the starch chains thus limiting the retrogradation (Ravenelle & Rahmouni, 2006;Whistler et al, 1984). The gelatinization step is essential to increase the hydrophilicity of the final excipient.…”

Section: Crosslinked High Amylose Starch Excipient For Controlled Drumentioning

confidence: 99%

“…CHAS is used in the direct compression of a large variety of drugs ranging from soluble to insoluble in water, and the release profile of the drug could be easily controlled and adapted (Ravenelle & Rahmouni, 2006). In comparison to well-known excipients such as microcrystalline cellulose or hydroxypropylmethyl cellulose, tablets made of CHAS do not dissolve or disintegrate upon hydration (Fig.…”

Section: Crosslinked High Amylose Starch Excipient For Controlled Drumentioning

confidence: 99%

“…The results observed show that the mechanical properties of the network formed upon hydration by the formation of the B-type double helices is not altered by the temperature variations. The gelatinization of a suspension of CHAS powder in water is observed between 60 and 100°C (Ravenelle & Rahmouni, 2006). The gelatinization is associated with the loss of the crystalline domains.…”

Section: Temperature Effectmentioning

confidence: 99%

See 2 more Smart Citations

NMR spectroscopy and imaging studies of pharmaceutical tablets made of starch

Thérien-Aubin

Zhu

2009

Carbohydrate Polymers

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Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

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The pressing need for the development of diversified and non‐toxic biomaterials in recent decades has led to the emergence of novel and valuable structural modifications in polysaccharides to broaden their spectrum of applications. Polysaccharides are macromolecules with multifaceted diverse structures and exhibit wide range of pharmacological and biological activities. Naturally occurring polysaccharides such as starch, chitosan, alginate, acetalated dextran and pectin could potentially negate major concerns associated with the selection of suitable polysaccharides without compromising their unique bioactive nature. Chemical modification of polysaccharides offers distinctive benefits such as improved biocompatibility, stability, solubility, and functionality making them more valuable for a variety of biomedical applications such as drug delivery, gene delivery, cell culture technology and tissue engineering. The present review is a compendium of relevant chemically modified polysaccharides and discusses their role in diverse fields of pharmacy and medicine.

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Contramid®: High-Amylose Starch for Controlled Drug Delivery

Cited by 16 publications

References 1 publication

Influence of Alcohol on the Release of Tramadol from 24-h Controlled-Release Formulations During In Vitro Dissolution Experiments

Influence of Alcohol on the Release of Tramadol from 24-h Controlled-Release Formulations During In Vitro Dissolution Experiments

NMR spectroscopy and imaging studies of pharmaceutical tablets made of starch

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

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