Contrast and resolution analysis of angular domain imaging for iterative optical projection tomography reconstruction

Ng, Eldon; Vasefi, Fartash; Kaminska, Bożena; Chapman, Glenn H.; Carson, Jeffrey J. L.

doi:10.1117/12.843099

Cited by 1 publication

(2 citation statements)

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“…The background region consisted of a similarly sized area adjacent to the target position. In typical AFA based angular domain imaging, the attenuation signal from an absorbing target is not perfectly localized to the target position 10 . This is due to the imperfect nature of the angular filtration.…”

Section: Image Pre-processingmentioning

confidence: 99%

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Multispectral angular domain imaging with a tunable pulsed laser light source

Vasefi

Carson

2012

SPIE Proceedings

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Angular Domain Imaging (ADI) is an imaging technique that is capable of generating three dimensional images of attenuating targets embedded in a scattering medium. In ADI, an angular filter is positioned between the sample and the detector to discriminate between quasi-ballistic photons and scattered photons. Quasi-ballistic photons have undergone relatively few forward directed scattering events, and can be used to generate a projection image representative of the imaging target. Scattered photons have undergone many scattering events and contain little information regarding the imaging target, thereby leading to decreased image contrast. Our implementation of ADI utilizes a silicon micro-channel array to reject scattered photons based on the angle at which they exit the sample. The objective of this work was to collect ADI images with a tunable pulsed laser within the visible range. Samples were illuminated at 13 wavelengths between 460 nm and 700 nm. An angular filter array of 80 µm x 80 µm tunnels 2-cm long was used to select the quasiballistic photons. Images were detected with a linear 16-bit linear CCD. The phantom consisted of a 0.7 mm attenuating target submerged in one of four Intralipid ® dilutions (0.15%-0.3%) contained within a 1 cm path length cuvette. Image contrast ranged from 0.02 at 460 nm and 0.3% Intralipid ® to 1 at 680 nm at 0.15% Intralipid ® . For a given scattering level, contrast increased at longer wavelengths. Resolution varied minimally with wavelength. The results suggested that multispectral ADI with a tunable pulsed laser is feasible and may find utility in imaging thin tissue samples in the future.

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Section: Image Pre-processingmentioning

confidence: 99%

“…1a) [5][6][7][8][9][10] , an array of microchannels etched into a silicon wafer. When the AFA is precisely aligned with the axis of illumination, ballistic and quasiballistic photons can pass freely through the channels, while scattered photons tend to strike the walls of the channels and attenuate.…”

Section: Angular Domain Imagingmentioning

confidence: 99%