Contrast-enhanced MRI for the assessment of myocardial viability after permanent coronary artery occlusion

Pereira, Raoul S.; Prato, Frank S.; Lekx, Katie S.; Sykes, Jane; Wisenberg, Gerald

doi:10.1002/1522-2594(200008)44:2<309::aid-mrm19>3.0.co;2-2

Cited by 35 publications

(32 citation statements)

References 35 publications

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“…Our observation of a lack of hyperenhancement for hyperacute nonreperfused infarct is in contrast to previous animal studies that reported that myocardial infarction, regardless of reperfusion, would show delayed hyperenhancement in postcontrast MR images throughout the entire process of infarction healing (8,15). This discrepancy may be due to the different animal models used in the experiments.…”

Section: Discussioncontrasting

confidence: 99%

Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages

Wang

Sun²,

Cao³

et al. 2006

Magnetic Resonance Imaging

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Purpose: To investigate delayed hyperenhancement during different healing stages of myocardial infarct with and without reperfusion in a pig model. Materials and Methods:Twelve pigs were studied. Six pigs were subjected to permanent right coronary artery (RCA) occlusion, and the other six were subjected to transient 90-minute RCA occlusion. In vivo MRI including first-pass perfusion and myocardial delayed enhancement (MDE) was performed at four, eight, 12, and 24 hours, and eight days after the artery occlusion. The MDE scan was repeated four times, two to 32 minutes after contrast administration.Results: For all six pigs without reperfusion, the four-hour MRI showed transmural perfusion defect and no delayed hyperenhancement; from eight hours on, delayed hyperenhancement appeared and its spatial extent gradually increased until it became transmural hyperenhancement at eight days. However, in all six pigs with reperfusion, hyperenhancement was present at every stage from four hours to eight days. Pathology confirmed the existence of infarct at various stages of healing irrespective of reperfusion status. Conclusion:Occlusive hyperacute infarct did not exhibit any delayed hyperenhancement, which indicates that perfusion plays an important role in delayed enhancement at the hyperacute stage.

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Section: Discussioncontrasting

confidence: 99%

Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages

Wang

Sun²,

Cao³

et al. 2006

Magnetic Resonance Imaging

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“…However, the absence of MR imaging contrast after a bolus injection has become an accepted, albeit qualitative, standard. We have characterized tissue blood flow in these 2 animal models using microspheres in the past (15,16). …”

Section: Discussionmentioning

confidence: 99%

Can the Inflammatory Response Be Evaluated Using ¹⁸F-FDG Within Zones of Microvascular Obstruction After Myocardial Infarction?

et al. 2015

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“…[25][26][27] An electrocardiogram-gated segmented cine FLASH sequence with echo sharing (TR/TE 60/4.8 msec, α 20°, thickness 6 mm) was used to obtain five to six short axis slices through the heart. Depending on the heart rate, eight to ten cardiac phases were acquired with a rectangular FOV.…”

Section: B) Cine Mrimentioning

confidence: 99%

“…Previous works in our laboratory and others have validated this technique of contrast-enhanced MRI against triphenyltetrazolium chloride histochemical staining to delineate myocardial necrosis. 20,21,25,26,28 AnalyzeAVW (Biomedical Imaging Resources, Mayo Foundation, Rochester, MN, USA) was used to volume render the Gd-DTPA enhanced 3D ex vivo images. The left ventricle (LV) volume was determined, as was the volume of enhanced tissue, which indicates myocardial necrosis.…”

Section: C) Contrast-enhanced Mrimentioning

confidence: 99%

“…Blood flow determination (F, expressed in mL·min -1 ·g -1 ) has been previously described in detail. 20,21,23,26,27 Infarct ratio To minimize the biological variability between animals we normalized the infarct size based on the region at risk (RAR). The RAR was defined as the volume of tissue with myocardial blood flows less than 0.3 mL·min -1 ·g -1 during occlusion, as determined by the microsphere data.…”

Section: Blood Flow Measurementsmentioning

confidence: 99%

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Similar long-term cardiovascular effects of propofol or isoflurane anesthesia during ischemia/ reperfusion in dogs

Thompson

Wisenberg

Sykes

et al. 2002

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To compare the long-term functional and metabolic effects of propofol or isoflurane general anesthesia in a canine model of ischemia/reperfusion. M Me et th ho od ds s: :Using magnetic resonance (MR) techniques, we monitored both regional metabolism ( 31 P MR spectroscopy) and systolic function of the heart ( 1 H MR imaging) throughout a two-hour occlusion of the left anterior descending coronary artery and ten days of reperfusion. Twenty-two beagles were randomized into isoflurane and propofol general anesthesia groups (n = 10, n = 12 respectively). Contrast-enhanced MR imaging was used to measure infarct size (% of left ventricle that was necrotic) and coronary blood flow was determined using radioactively labelled microspheres.R Re es su ul lt ts s: : Cardiac metabolism, as monitored by intracellular pH and high-energy phosphate ratios, was not significantly different between the two groups throughout the protocol. Relative to propofol, isoflurane reduced the depression of left ventricular ejection fraction (EF) during the ischemic period [isoflurane 68.5% ± 4.2%, propofol 58.3% ± 2.0% of baseline (B); P = 0.04], propofol increased the recovery of EF at day three (isoflurane 63.9% ± 4.3%, propofol 74.0% ± 2.5% of B; P = 0.05). By day ten, EF in both groups was similar. Infarct sizes were also similar at day ten (isoflurane 15.7% ± 3.0%, propofol 13.2% ± 2.2%). Normalizing these by the region at risk (volume of tissue with low blood flow during the occlusion) to assess infarct ratios was also not significant (isoflurane 0.58% ± 0.08%, propofol 0.54% ± 0.07%).C Co on nc cl lu us si io on ns s: : There were no significant differences between the two anesthetic groups at day ten, suggesting that any apparent dissimilarities in early cardiovascular effects were short-term only. These results indicate that isoflurane and propofol produce equivalent long-term cardiovascular effects following ischemia/reperfusion. [isoflurane : 68,5 %± 4,2 %, propofol : 58,3 % ± 2,0 % des données de base (B) ; P = 0,04], le propofol a accéléré la récupération de la FE au jour trois (isoflurane : 63,9 % ± 4,3 %, propofol : 74,0 % ± 2,5 % de B ; P = 0,05). Au dixième jour, la FE était similaire dans les deux groupes, de même la taille de l'infarctus (isoflurane : 15,7 % ± 3,0 %, propofol : 13,2 % ± 2,2 %). La normalisation de ces données, selon la région à risque (volume de tissu soumis à un faible débit sanguin pendant l'occlusion), réalisée pour évaluer les ratios d'infarctus n'a pas été significative non plus (isoflurane : 0,58 % ± 0,08 %, propofol : 0,54 % ± 0,07 %). Objectif : Comparer les effets fonctionnels et métaboliques prolongés de l'anesthésie générale avec du propofol ou de l'isoflurane chez un modèle canin d'ischémie/reperfusion. Méthode : Nous avons mesuré, grâce aux techniques d'imagerie par résonance magnétique (IRM), le métabolisme régional (spectroscopie IRM 31P) et la fonction systolique cardiaque (IRM 1H) tout au long d'une occlusion de deux heures de l'artère descendante antérieure et...

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Contrast-enhanced MRI for the assessment of myocardial viability after permanent coronary artery occlusion

Cited by 35 publications

References 35 publications

Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages

Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages

Can the Inflammatory Response Be Evaluated Using ¹⁸F-FDG Within Zones of Microvascular Obstruction After Myocardial Infarction?

Similar long-term cardiovascular effects of propofol or isoflurane anesthesia during ischemia/ reperfusion in dogs

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Contrast-enhanced MRI for the assessment of myocardial viability after permanent coronary artery occlusion

Cited by 35 publications

References 35 publications

Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages

Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages

Can the Inflammatory Response Be Evaluated Using 18F-FDG Within Zones of Microvascular Obstruction After Myocardial Infarction?

Similar long-term cardiovascular effects of propofol or isoflurane anesthesia during ischemia/ reperfusion in dogs

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Can the Inflammatory Response Be Evaluated Using ¹⁸F-FDG Within Zones of Microvascular Obstruction After Myocardial Infarction?