Contrast‐Enhanced Ultrasound Differentiation Between Low‐ and High‐ Grade Bladder Urothelial Carcinoma and Correlation With Tumor Microvessel Density

Guo, Shu; Xu, Pan; Aiyun, Zhou; Wang, Gongxian; Chen, Weimin; Mei, Jinhong; Xiao, Fan; Liu, Juan; Zhang, Cheng

doi:10.1002/jum.14262

Cited by 22 publications

(22 citation statements)

References 33 publications

(59 reference statements)

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“…In this case, the quantitative analysis showed the TIC characterized by high signal intensity, rapid wash-in, and early wash-out. This is similar to the results of Guo et al [10], which displayed tumor with high-grade microvessel density, with high signal intensity and a fast wash-out. Therefore, CEUS, with TIC analysis, may be a useful non-invasive method in preoperatively evaluating the angiogenesis of bladder carcinoma.…”

Section: Discussionsupporting

confidence: 92%

“…Angiogenesis plays important role in the vascularization, growth, and metastasis of tumors. It is reported that a early wash-out enhancement pattern is common in arteriovenous fistulas as a result of angiogenesis, with a less distribution of tortuous vessels and interstitial oedema vessels related to a quick wash-out of contrast agent from the blood vessels [10]. In this case, the quantitative analysis showed the TIC characterized by high signal intensity, rapid wash-in, and early wash-out.…”

Section: Discussionmentioning

confidence: 65%

“…CEUS can provide real-time visualization of contrast-enhanced patterns, which is useful for the differential diagnosis of urinary bladder lesions [7][8][9]. In addition, using the pattern of time-intensity curves (TIC) can reflect the tumor microvessel density, which may be helpful in evaluating tumoral neovascularisation in bladder tumors [8,10].…”

Section: Introductionmentioning

confidence: 99%

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Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report

Kang

et al. 2020

BMC Med Imaging

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Background: Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is an uncommon malignant bladder tumor, and the overall prognosis is poor. Contrast-enhanced ultrasound (CEUS) provides a new effective modality for tumor detection and diagnosis. Case presentation: A 30-year-old man complained of repeated painless gross haematuria for half a month. Conventional ultrasound demonstrated a hypoechoic solitary lesion with hyperechoic margins measuring 3.4 × 3.1 cm in the anterior wall of the bladder. Superb microvascular imaging (SMI) showed a strong flow signal in the mass. CEUS revealed that the lesion was characterized by hyper-enhancement in the early phase and hypoenhancement in the late phase. The entire bladder wall was disrupted by homogeneous hyper-enhanced tumor tissue on CEUS. Time-intensity curves (TICs) showed a rapid wash-in with a high maximum signal intensity (SI) and quick wash-out. Finally, partial cystectomy was performed and the pathological examination confirmed the diagnosis of LCNEC with invasion into the whole layer of the bladder wall. Conclusion: This case suggested that CEUS was a valuable imaging method to detect and diagnose LCNEC in the bladder, and that CEUS can provide information related to the depth of wall invasion and the microvasculature.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report

Kang

et al. 2020

BMC Med Imaging

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“…The intratumoral MVD in the bladder cancer tissue were measured by immunohistochemistry. 38,39 The 4-µm rat bladder tissue paraffin sections were deparaffinized, rehydrated, and treated with 3% hydrogen peroxide (H 2 O 2 ) to remove endogenous peroxidase. Then they were incubated with the primary anti-CD34 antibody (Abcam, Shanghai, China) overnight at 4°C.…”

Section: Immunohistochemical Assaymentioning

confidence: 99%

Lumbrokinase/paclitaxel nanoparticle complex: potential therapeutic applications in bladder cancer

Yan

Tong

et al. 2018

IJN

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BackgroundLumbrokinase (LK) is an enzyme complex with antithrombotic, antioxidant, antitumor, and immunomodulatory effects. It has been extensively studied and used in clinical anti-tumor therapy. However, its half-life is short, its bioavailability is low, and its toxicity and side effects are great, which greatly limit its clinical application. Therefore, LK is often combined with other drugs (such as immune agents, hormones, or Chinese herbal medicine) to reduce its dosage and side effects and to improve its anti-tumor effects.Methods and resultsHere, we described an LK/paclitaxel (PTX) nanocarrier based on poly(ethylene glycol)-b-(poly(ethylenediamine l-glutamate)-g-poly(ε-benzyoxycarbonyl-l-lysine)-r-poly(l-lysine)) (PEG-b-(PELG-g-(PZLL-r-PLL))). In the present study, LK and PTX were loaded by electrostatic and/or hydrophobic effects under mild conditions, thereby increasing the half-life and bioavailability of the drugs via the sustained release and enhancement of tumor site enrichment by the LK/PTX/PEG-b-(PELG-g-(PZLL-r-PLL)) complex through passive targeting. In this study, using bladder cancer cells (J82 cells) and rat bladder cancer model as the object, the structure of the nanocarrier, the relationship between drugs composition and antitumor properties were systematically studied.ConclusionWe propose that the block copolymer PEG-b-(PELG-g-(PZLL-r-PLL)) may function as a potent nanocarrier for augmenting anti-bladder cancer pharmacotherapy, with unprecedented clinical benefits.

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“…Contrast-enhanced ultrasound (CEUS) has been shown to be a practical method of detecting the features of tumor angiogenesis in many studies, some of which investigated the correlation between CEUS parameters and MVD or VEGF expression to assess tumor angiogenesis [18,19]. CEUS has the ability to gather micro-vascular information in various organs, which increases the accuracy of tumor diagnosis [17,[20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced Ultrasound in evaluating of angiogenesis and tumor staging of nasopharyngeal carcinoma in nude mice

et al. 2019

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Objective To explore the use of Contrast-enhanced Ultrasound (CEUS) in evaluating angiogenesis in a xenograft nasopharyngeal carcinoma (NPC) model in nude mice and the evolution of CEUS parameters according to the growth of NPC. Methods Nude mice were divided into three groups according to experiments conducted at various times from tumor implantation (8 mice/group; group A: 4 weeks from implantation; group B:6 weeks from implantation; group C:8 weeks from implantation). CNE-2 cells were transplanted in 24 nude mice and CEUS evaluations of the tumors were performed at 4, 6 or 8 weeks from implantation. CEUS parametric perfusion images and pathological findings were recorded. R version 3.4.4 software was used to analyze the CEUS parameters and pathological findings. Results One-way anova analysis indicated statistically significant differences among the three groups with the parameters of peak intensity (PI) (p<0.001), area wash in (AWI) (p<0.001), area wash out (AWO) (p<0.001) and tumor volumes (p<0.001).Pearson correlation coefficient analysis indicated that microvessel density (MVD) was correlated with tumor volume

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Contrast‐Enhanced Ultrasound Differentiation Between Low‐ and High‐ Grade Bladder Urothelial Carcinoma and Correlation With Tumor Microvessel Density

Cited by 22 publications

References 33 publications

Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report

Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report

Lumbrokinase/paclitaxel nanoparticle complex: potential therapeutic applications in bladder cancer

Contrast-enhanced Ultrasound in evaluating of angiogenesis and tumor staging of nasopharyngeal carcinoma in nude mice

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