Contrast‑enhanced ultrasound is better than magnetic resonance imaging in evaluating the short‑term results of microwave ablation treatment of uterine fibroids

Zhang, Yan; Zhang, Meiwu; Fan, Xiaoxiang; Mao, Dafeng

doi:10.3892/etm.2017.5171

Cited by 3 publications

(5 citation statements)

References 13 publications

(14 reference statements)

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“…[ 1 ] The common symptoms of UFs are abnormal menstrual bleeding, urinary or pelvic discomfort, dysmenorrhea, dyspareunia, infertility, and repeated miscarriages, seriously affecting the quality of patients’ life. [ 1 , 2 ] At present, comprehensive application of traditional surgery (myomectomy or hysterectomy), drug treatment, [ 3 ] radiofrequency ablation, [ 4 , 5 ] microwave ablation, [ 6 , 7 ] and uterine artery embolization [ 8 – 10 ] greatly improves the treatment outcome of UFs. Even so, these methods have some traumatic and limitations, including the risk of infection, postembolization syndrome and permanent amenorrhea.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-guided high-intensity focused ultrasound in the treatment of uterine fibroids

et al. 2019

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The aim of the present study was to investigate factors affecting ablation effect and safety of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids (UFs).A retrospective analysis of 346 patients with symptomatic UFs who were treated with USgHIFU was performed. All UFs was grouped based on magnetic resonance imaging (MRI) characteristics before HIFU; all adverse events and treatment data were recorded during and after HIFU. One-way analysis of variance and multiple linear regression analysis were used to evaluate the effect of USgHIFU treatment and affecting factors.The results showed that the mean age of patients was 38.3 ± 6.1 years, with the mean nonperfusion volume rate of 74.4 ± 14.7% and the mean energy efficiency factor (EEF) of 7.2 ± 4.8 J/mm3. Except for the size group, the ablation rate was significantly different (P < .001); and the anterior, intramural, hypointense (T2WI), and mild enhancement (T1WI contrast enhancement) UFs had the highest ablation rate. The EEF of the anterior, intramural, hypointense (T2WI), mild enhancement (T1WI contrast enhancement), and >5 cm UFs had minimum value, with a statistically significant difference (P < .01). According to multiple linear regression model, the distance from the UFs ventral side to the skin, enhancement type on T1WI, size of UFs, signal intensity on T2WI, location of UFs, type and volume of fibroids all had a line relationship with EEF, and the enhancement type on T1WI was the greatest factor affecting the ablation effect. Some patients (37.6%) had thermal injury of the sacrum on MRI, but no serious adverse events were observed.Our results suggest that USgHIFU can be safely used and have a promising prospect for treating UFs, even though its effect may be affected by anatomical features, tissue characteristics, and blood supply.

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Section: Introductionmentioning

confidence: 99%

Ultrasound-guided high-intensity focused ultrasound in the treatment of uterine fibroids

et al. 2019

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“…Where HIFU works within diagnostic frequencies (0.6–5.0 MHz), microwave ablation works with electromagnetic waves (900–2450 MHz) and is typically used to ablate larger tumors (>3.0 cm). 57 Four studies demonstrated the use of CEUS for monitoring microwave ablation of fibroids, 31,33,36,38 and two studies for monitoring this treatment of adenomyosis. 37,40 Quantitative analysis demonstrated good agreement between contrast-enhanced MRI and CEUS for detecting non-perfused volume after microwave ablation of fibroids (ICC = 0.991) 33 and ablation rate in adenomyosis ( R = 0.81).…”

Section: Resultsmentioning

confidence: 99%

“…Remarkably, none of the studies that used CEUS as a diagnostic tool performed an MRI, all used histology as reference test. Fifteen studies performed MRI as post-treatment imaging modality, of which six studies described that results obtained with both CEUS and MRI were similar [27][28][29]38,41,45 and four studies made a statistical comparison of CEUS with MRI 33,35,40,47 in gynecology. In the characterization of nongynecology malignancies, for example focal hepatic lesions and recognizing malignancies, there are studies showing a similar-to-higher accuracy of CEUS compared with MRI.…”

Section: Discussionmentioning

confidence: 99%

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Contrast-Enhanced Ultrasound Imaging of Uterine Disorders: A Systematic Review

et al. 2021

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Uterine disorders are often presented with overlapping symptoms. The microvasculature holds specific information important for diagnosing uterine disorders. Conventional sonography is an established diagnostic technique in gynecology, but is limited by its inability to image the microvasculature. Contrast-enhanced ultrasound (CEUS), is capable of imaging the microvasculature by means of intravascular contrast agents; that is, gas-filled microbubbles. We provide a literature overview on the use of CEUS in diagnosing myometrial and endometrial disorders, that is, fibroids, adenomyosis, leiomyosarcomas and endometrial carcinomas, as well as for monitoring and enhancing the effectiveness of minimally invasive therapies. A systematic literature search with quality assessment was performed until December 2020. In total 34 studies were included, published between 2007 and 2020.The results entail a description of contrast-enhancement patterns obtained from healthy tissue and from malignant and benign tissue; providing a first base for potential diagnostic differentiation in gynecology. In addition it is also possible to determine the degree of myometrial invasion in case of endometrial carcinoma using CEUS. The effectiveness of minimally invasive therapies for uterine disorders can safely and accurately be assessed with CEUS. In conclusion, the abovementioned applications of CEUS are promising and it is worth further exploring its full potential for gynecology by designing innovative and methodologically high-quality clinical studies.

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“…Contrast-enhanced ultrasound (CEUS) is a promising non-invasive technique that can more intuitively and efficiently reveal the blood supply or perfusion characteristics of tumors. CEUS has been widely used to distinguish between benign and malignant lesions in the breast, thyroid, liver, and other organs, and it has also been used to monitor tumor response after neoadjuvant chemotherapy and to evaluate the effect of radiofrequency or microwave ablation (6)(7)(8)(9)(10)(11). However, there was no report on the assessment of laryngeal cancer by CEUS.…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced ultrasound for the preoperative assessment of laryngeal carcinoma: a preliminary study

et al. 2020

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Background Contrast-enhanced ultrasound (CEUS) is considered an attractive imaging technique to evaluate tumor microcirculation. However, the validity of CEUS for assessing laryngeal carcinoma is unclear. Purpose To compare the performance of CEUS with conventional US and contrast-enhanced computed tomography (CECT) in the diagnosis and preoperative T-staging of laryngeal carcinoma. Material and Methods Forty-one consecutive patients with laryngeal carcinoma underwent conventional high-frequency US, CEUS, and CECT before surgery. The CEUS characteristics of laryngeal carcinoma were recorded. The imaging findings of CEUS and conventional US were compared with CECT findings and the postoperative pathological examination. Results CEUS showed hyperenhancement in 38 cases and isoenhancement in three cases. Homogeneous distribution of contrast agent was found in 20 cases and heterogeneous distribution in 21 cases, of which 16 cases showed local perfusion defects. In the enhanced phase, rapid entry was observed in 37 cases, synchronous entry was observed in two cases, and slow entry was observed in two cases. Rapid exit was observed in 25 cases and slow exit was observed in 16 cases. The pretherapeutic T-staging accuracy was not significantly different between conventional US, CEUS, and CECT ( P ≥ 0.500). A high sensitivity and specificity were achieved by CEUS in the evaluation of involvement of thyroid cartilage. Conclusion Compared with conventional US and CECT, CEUS has a reliable initial T-staging accuracy and diagnostic properties for detecting laryngeal cartilage invasion.

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Contrast‑enhanced ultrasound is better than magnetic resonance imaging in evaluating the short‑term results of microwave ablation treatment of uterine fibroids

Cited by 3 publications

References 13 publications

Ultrasound-guided high-intensity focused ultrasound in the treatment of uterine fibroids

Ultrasound-guided high-intensity focused ultrasound in the treatment of uterine fibroids

Contrast-Enhanced Ultrasound Imaging of Uterine Disorders: A Systematic Review

Contrast-enhanced ultrasound for the preoperative assessment of laryngeal carcinoma: a preliminary study

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