Contrast-enhanced ultrasound with dispersion analysis for the localization of prostate cancer: correlation with radical prostatectomy specimens

Postema, Arnoud W.; Gayet, Maudy; Sloun, Ruud J. G. van; Wildeboer, Rogier R.; Mannaerts, Christophe K.; Savcı-Heijink, C. Dilara; Schalk, Stefan G.; Kajtazovic, Amir; Poel, Henk van der; Mulders, Peter F.A.; Beerlage, Harrie P.; Mischi, Massimo; Wijkstra, Hessel

doi:10.1007/s00345-020-03103-4

Cited by 10 publications

(19 citation statements)

References 43 publications

(56 reference statements)

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“… 18 – 23 In the past 5 years, however, mpUS has gain popularity in urology and radiology field. 30 , 94 – 101 …”

Section: Multiparametric Usmentioning

confidence: 99%

“…Postema et al . 96 evaluated the CSPCa (any GG ⩾3 and GG 2 larger than 0.5 ml) diagnostic performance of B-mode, CEUS, contrast ultrasound dispersion imaging (CUDI), and mpUS (combination of these three US modalities) with 133 men undergoing RP as the reference standard. CUDI, a computer-aided quantification technique, was generated from the CEUS recordings.…”

Section: Multiparametric Usmentioning

confidence: 99%

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Multiparametric ultrasound of prostate: role in prostate cancer diagnosis

Kaneko

Lenon

Ramacciotti

et al. 2022

Therapeutic Advances in Urology

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Recent advances in ultrasonography (US) technology established modalities, such as Doppler-US, HistoScanning, contrast-enhanced ultrasonography (CEUS), elastography, and micro-ultrasound. The early results of these US modalities have been promising, although there are limitations including the need for specialized equipment, inconsistent results, lack of standardizations, and external validation. In this review, we identified studies evaluating multiparametric ultrasonography (mpUS), the combination of multiple US modalities, for prostate cancer (PCa) diagnosis. In the past 5 years, a growing number of studies have shown that use of mpUS resulted in high PCa and clinically significant prostate cancer (CSPCa) detection performance using radical prostatectomy histology as the reference standard. Recent studies have demonstrated the role mpUS in improving detection of CSPCa and guidance for prostate biopsy and therapy. Furthermore, some aspects including lower costs, real-time imaging, applicability for some patients who have contraindication for magnetic resonance imaging (MRI) and availability in the office setting are clear advantages of mpUS. Interobserver agreement of mpUS was overall low; however, this limitation can be improved using standardized and objective evaluation systems such as the machine learning model. Whether mpUS outperforms MRI is unclear. Multicenter randomized controlled trials directly comparing mpUS and multiparametric MRI are warranted.

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“… 18 – 23 In the past 5 years, however, mpUS has gain popularity in urology and radiology field. 30 , 94 – 101 …”

Section: Multiparametric Usmentioning

confidence: 99%

Section: Multiparametric Usmentioning

confidence: 99%

Multiparametric ultrasound of prostate: role in prostate cancer diagnosis

Kaneko

Lenon

Ramacciotti

et al. 2022

Therapeutic Advances in Urology

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“…Perfusion strength, strain pattern, with or without focal no-strain were assessed. PCa of mpUS was assessed according to the EFSUMB2017 guidelines, WFUMB2017 guidelines, and literature reports [10][11][12][13][14].…”

Section: Ceus and Tres Of The Target Areamentioning

confidence: 99%

The combined value of mpUS and mpMRI-TRUS fusion for the diagnosis of clinically significant prostate cancer

2022

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Objective To evaluate the combined efficacy of multiparametric ultrasonography (mpUS) and multiparametric magnetic resonance imaging/transrectal ultrasound (mpMRI-TRUS) fusion for detecting clinically significant prostate cancer (csPCa). Methods From November 2019 to September 2021, biopsy-naïve patients underwent mpMRI-TRUS fusion imaging combined with mpUS-guided targeted biopsies (TB) and systematic biopsies (SB). To further evaluate the additional diagnostic value of mpUS, the imaging features of 202 focus obtained from fusion imaging were assessed. The diagnostic accuracies of mpMRI-TRUS fusion imaging and the combination of mpMRI-TRUS fusion imaging with mpUS for csPCa were comparatively evaluated. Results A total of 202 prostate lesions (160 patients) were included in the final analysis, of which 105 were csPCa, 16 were ciPCa, and 81 were noncancerous. The median patient age was 69 (65–73) years and the median tPSA was 22.07 (11.22–62.80) ng/mL. For csPCa, the detection rate of TB was higher than that of SB (50.0% vs. 45.5%, p < 0.05). The imaging characteristics of mpUS in the PCa and non-PCa groups were significantly different (p < 0.001). When compared with mpMRI-TRUS fusion imaging, the positive predictive value, false positive rate, and area under the curve (AUC) of csPCa diagnosis by mpMRI-TRUS fusion imaging combined with mpUS increased by 11.30%, decreased by 19.58%, and increased from 0.719 to 0.770 (p < 0.05), respectively. Conclusion TB can improve the detection rate of csPCa and hence can be effectively used in the diagnosis and risk assessment of csPCa. The mpUS-enriched valuable diagnostic information for mpMRI-TRUS fusion imaging and their combination showed a higher diagnostic value for csPCa, which can guide subsequent clinical treatment.

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“…However, the results cannot be compared with SBx due to the lack of targeted sampling. In the next step, Postema et al aimed to determine the values of CEUS and CUDI in correlation with radical prostatectomy specimens [81]. This multicenter study included 133 men scheduled for radical prostatectomy with preoperative CEUS imaging and generation of CUDI parametric maps.…”

Section: Contrast-enhanced Ultrasoundmentioning

confidence: 99%

Alternatives for MRI in Prostate Cancer Diagnostics—Review of Current Ultrasound-Based Techniques

Gurwin

Kowalczyk

Knecht-Gurwin

et al. 2022

Cancers

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The purpose of this review is to present the current role of ultrasound-based techniques in the diagnostic pathway of prostate cancer (PCa). With overdiagnosis and overtreatment of a clinically insignificant PCa over the past years, multiparametric magnetic resonance imaging (mpMRI) started to be recommended for every patient suspected of PCa before performing a biopsy. It enabled targeted sampling of the suspicious prostate regions, improving the accuracy of the traditional systematic biopsy. However, mpMRI is associated with high costs, relatively low availability, long and separate procedure, or exposure to the contrast agent. The novel ultrasound modalities, such as shear wave elastography (SWE), contrast-enhanced ultrasound (CEUS), or high frequency micro-ultrasound (MicroUS), may be capable of maintaining the performance of mpMRI without its limitations. Moreover, the real-time lesion visualization during biopsy would significantly simplify the diagnostic process. Another value of these new techniques is the ability to enhance the performance of mpMRI by creating the image fusion of multiple modalities. Such models might be further analyzed by artificial intelligence to mark the regions of interest for investigators and help to decide about the biopsy indications. The dynamic development and promising results of new ultrasound-based techniques should encourage researchers to thoroughly study their utilization in prostate imaging.

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Contrast-enhanced ultrasound with dispersion analysis for the localization of prostate cancer: correlation with radical prostatectomy specimens

Cited by 10 publications

References 43 publications

Multiparametric ultrasound of prostate: role in prostate cancer diagnosis

Multiparametric ultrasound of prostate: role in prostate cancer diagnosis

The combined value of mpUS and mpMRI-TRUS fusion for the diagnosis of clinically significant prostate cancer

Alternatives for MRI in Prostate Cancer Diagnostics—Review of Current Ultrasound-Based Techniques

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