Contrast-enhanced US in Pediatric Patients: Overview of Bowel                     Applications

Gokli, Ami; Acord, Michael; Hwang, Misun; Medellin-Kowalewski, Alexandra; Rubesova, Erika; Anupindi, Sudha A.

doi:10.1148/rg.2020200019

Cited by 7 publications

(1 citation statement)

References 82 publications

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“…Although CDUS can help detect reduced perfusion, it requires significant patient cooperation during the examination; therefore, perfusion-localized lesions are often missed in infants [ 4 , 14 ]. CEUS can show a more objective hypoperfusion area and is less sensitive to the patient’s motion, allowing a relatively accurate assessment of kidney perfusion [ 15 ]. Therefore, CEUS can be an excellent alternative for detecting renal parenchymal lesions in pediatric febrile UTI patients.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasound for the diagnosis of acute pyelonephritis in pediatric patients with urinary tract infection: A feasibility study

et al. 2023

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Purpose This study aimed to assess the feasibility of contrast-enhanced ultrasound (CEUS) for the diagnosis of acute pyelonephritis (APN) in pediatric patients with febrile urinary tract infection (UTI). Materials and methods Between March 2019 and January 2021, study participants with suspected UTI were assessed for APN using ultrasound. Parenchymal echogenicity changes, renal pelvis dilatation, and the presence of a focal suspected lesion were assessed using conventional grayscale ultrasound. The presence and location of a decreased perfusion area were evaluated using color Doppler ultrasound (CDUS) and CEUS. Agreement between each ultrasound examination and a 99mTc‒dimercaptosuccinic acid (DMSA) scan was assessed using the κ value, and the most visible period of the lesion was evaluated using CEUS. Results This study enrolled 21 participants (median age, 8.0 months; range, 2.0–61.0 months) with isolated urinary tract pathogens. Five increased parenchymal echotextures (11.9%) and 14 renal pelvic dilatations (33.3%) were confirmed, but no focal lesions were detected on the grayscale images. CDUS and CEUS showed decreased local perfusion suggestive of APN in two and five kidneys, respectively. DMSA scan showed substantial agreement with CEUS findings (κ = 0.80, P = 0.010), but other grayscale and CDUS findings did not agree with DMSA scan results (P > 0.05). All lesions were best observed in the late parenchymal phase on CEUS. Conclusion CEUS can reveal renal perfusion defects in pediatric patients with suspected APN without radiation exposure or sedation; therefore, CEUS may be a feasible and valuable diagnostic technique.

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Section: Discussionmentioning

confidence: 99%