Contrast enhancement of magnetic resonance imaging (MRI) of polymer gel dosimeter by adding Platinum nano- particles

Deyhimihaghighi, N.; Noor, Noramaliza Mohd; Soltani, Nayereh; Jorfi, Rahele; Haghir, M. Erfani; Adenan, Mohd Zulfadli; Saion, Elias; Khandaker, Mayeen Uddin

doi:10.1088/1742-6596/546/1/012013

Cited by 12 publications

(7 citation statements)

References 7 publications

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“…To increase the accuracy, some antioxidant (THPC) was added to the gel to scavenge oxygen and the experiment was repeated several times. Employing gel dosimeters for evaluation radiation dose enhancement due to present high-atomic number nanoparticles such as gold, iodine, gadolinium, and platinum has been demonstrated in previous works (Meesat et al 2009, Rahman et al 2012, Deyhimihaghighi et al 2014, Amirrashedi et al 2015.…”

Section: Discussionmentioning

confidence: 99%

Multifunction bismuth gadolinium oxide nanoparticles as radiosensitizer in radiation therapy and imaging

et al. 2019

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Multifunction bismuth-based nanoparticles with the ability to display diagnostic and therapeutic functions have drawn extensive attention as theranostic agents in radiation therapy and imaging due to their high atomic number, low toxicity, and low cost. Herein, we tried to introduce multifunction bismuth gadolinium oxide nanoparticles (BiGdO3) as a new theranostic agent for radiation therapy, computed tomography (CT) and magnetic resonance imaging (MRI). After synthesis of BiGdO3 nanoparticles and surface modifications of them with PEG, biocompatibility of the nanoparticles was evaluated by a CCK-8 assay. We investigated dose amplification properties of the nanoparticles using gel dosimetry and in vitro and in vivo assays. According to clonogenic assay radiation, a sensitizer enhancement ratio (SER) of 1.75 and 1.66 (100 µg ml−1-nanoparticles), for MCF-7 and 4T1 cell lines at low energy x-ray was achieved, respectively. Radiation dose enhancement effect of the nanoparticles was proven for high concentrations (500 µg ml−1) by gel dosimetry. For further investigation, in vivo cancer radiotherapy was carried out using female BALB/c mice with 4T1 breast tumors. In vivo results emphasized the radiosensitizing effect of BiGdO3-PEG nanoparticles. Both bismuth and gadolinium provide CT contrast, while gadolinium can be employed for MRI T1 contrast, so we evaluated contrast enhancement of BiGdO3-PEG nanoparticles as a dual-modal imaging agent in MR and CT imaging. Collectively, our experimental results clearly display properties of BiGdO3-PEG nanoparticles as multimodal imaging and radiosensitizing agents. The results show that the nanoparticles deserve further study as a new theranostic agent.

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Section: Discussionmentioning

confidence: 99%

Multifunction bismuth gadolinium oxide nanoparticles as radiosensitizer in radiation therapy and imaging

et al. 2019

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“…The findings of the studies carried out in the dose enhancement of NPs exposed to megavoltage beams are contradictory [34,35]. Acceptable DEFs induced by various NPs under the irradiation of 6oCo γ-rays, in the investigations of Maggiorella, Sabbaghizadeh, and Deyhimihaghighi were in contradiction with the results of Ezzati, Kakade, and Toossi studies [36][37][38][39][40][41]. Therefore, in this study, we investigate the potential of 50 nm AuNPs as radio-enhancer in the decayed energy from the Co-60 source compared with the Ir-192 source, using the MAGAT gel dosimeter.…”

Section: Introductionmentioning

confidence: 95%

Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

et al. 2018

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Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy. Many in-vivo and in-vitro investigations have indicated that gold nanoparticles (AuNPs) can significantly increase tumor injuries in low kilovoltage radiotherapy. While deep-lying tumors require much higher energy levels with greater penetration power, and investigations carried out in megavoltage energy range show contradictory results.Objective: In this study, we quantitatively assess and compare dose enhancement factors (DEFs) obtained through AuNPs under radiation of Cobalt-60 source (1.25MeV) versus Iridium-192 source (0.380 KeV) using MAGAT gel dosimeter.Material and Methods: MAGAT polymer gel in both pure and combined with 0.2 mM AuNPs was synthesized. In order to quantify the effect of energy on DEF, irradiation was carried out by Co-60 external radiotherapy and Ir-192 internal radiotherapy. Finally, readings of irradiated and non-irradiated gels were performed by MR imaging.Result: The radiation-induced R2 (1/T2) changes of the gel tubes doped with AuNPs compared to control samples, upon irradiation of beams released by Ir-192 source showed a significant dose enhancement (15.31% ±0.30) relative to the Co-60 external radiotherapy (5.85% ±0.14).Conclusion: This preliminary study suggests the feasibility of using AuNPs in radiation therapy (RT), especially in low-energy sources of brachytherapy. In addition, MAGAT polymer gel, as a powerful dosimeter, could be used for 3D visualization of radiation dose distribution of AuNPs in radiotherapy.

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“…The prominent biomedical applications of PtNPs are found to include, therapeutic effects 190 , anti-cancer therapy 191 , anti-tumor applications 192 , contrast agent in medical imaging 193 , antimicrobial activity 194 , anti-bacterial activities 195 , anti-oxidant effects 196 , cancer chemotherapy 197 , biosensors and intracellular analysis 198 , photothermal therapy 199 , as biocatalysts 200 and as biomarkers [201][202] .…”

Section: Biomedical Applications Of Pt Npsmentioning

confidence: 99%

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2017

IJPSR

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Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, during the last forty years. In these analyses, the prominent biomedical applications of ten metallic nanobiomaterials have been reviewed from various sources and works. It has been found that almost nine of them are used in a very wide spectrum of medical and theranostic applications.

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Contrast enhancement of magnetic resonance imaging (MRI) of polymer gel dosimeter by adding Platinum nano- particles

Cited by 12 publications

References 7 publications

Multifunction bismuth gadolinium oxide nanoparticles as radiosensitizer in radiation therapy and imaging

Multifunction bismuth gadolinium oxide nanoparticles as radiosensitizer in radiation therapy and imaging

Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

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