Contrast Media-Induced Chromosomal Damage in Human Lymphocyte Cultures

Parvez, Zaheer; M, Kormano; Moncada, Rogelio; Eklund, Ritva

doi:10.1097/00004424-198611000-00006

Cited by 7 publications

(1 citation statement)

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“…Several investigators found an increase in the frequency of abnormalities in peripheral blood leukocytes isolated from patients following diagnostic studies involving contrast agents (Adams et al 1977, 1984, Callisen et al 1979, Cochran et al 1980, Cochran and Norman 1982. These results were supported by experiments with cell cultures irradiated in the presence of contrast (Stenstrand and Edgren 1981, Hadnagy et al 1982, Matsubara et al 1982, Santos Mello et al 1983, Parvez et al 1986, Dawson et al 1987, 1988, Norman et al 1991, Herold et al 2000, Esteve et al 2002, Corde et al 2004.…”

Section: Introductionmentioning

confidence: 87%

Radiochromic film dosimetry of contrast-enhanced radiotherapy (CERT)

Morris¹,

M²,

Malzbender³

2006

Phys. Med. Biol.

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Contrast-enhanced radiotherapy (CERT) employs elevated concentrations of high-Z contrast media in targets to dramatically increase the absorbed dose of radiation relative to the surrounding tissues. However, it is difficult to measure the dose enhancement with routine clinical instruments because the photoelectrons and Auger electrons produced by the interaction of kilovoltage x-rays with the contrast agent travel extremely short distances. We have developed a technique utilizing unlaminated radiochromic film to measure the maximum dose enhancement factor attainable in solutions of contrast agent with iodine concentrations ranging from 0% to 37% (w/v). The films were also used to simultaneously measure the dose enhancement and beam attenuation through solutions containing 0%, 5% and 10% iodine (w/v). These depth-dose measurements were made in phantoms representing 3 cm targets located 0 and 4.8 cm deep in acrylic. Higher concentrations of contrast yielded greater dose enhancement and target-to-surface dose ratios, but caused more rapid attenuation of the beam as it traversed the target. The dose distribution across the entire target could be improved by employing multiple beams. These results, using concentrations of contrast that are clinically achievable by intratumoural injection, illustrate the potential of CERT for the specific delivery of high doses of radiation to targets at depth.

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