Contrast Media-Induced Immune Hemolytic Anemia

Ghailani, Hajar H Al; Alawi, Abdullah M Al; Hashim, Abdul Hakeem Al

doi:10.7759/cureus.14522

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…It is well known that the risk of an idiosyncratic allergic drug reaction varies with the treatment duration and most cases occur soon after a dose and are more common early after the first treatments [9][10][11]. Further, there are only very few cases in the available literature that show an association between an iodine-based contrast medium and the occurrence of agranulocytosis or hemolysis [12,13]. Moreover, we assume that both agranulocytosis and hemolysis are due to the same drug and not two different drugs independently of each other triggered rare complications at the same time.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

et al. 2023

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Background and objective Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole. Case Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole. Conclusion This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types. Key PointsAgranulocytosis and hemolysis occurred simultaneously as a result of the first and single administration of metamizole.It is unclear which individual factors determine the extent of a potential allergic reaction.Patients receiving metamizole for the first time may benefit from a close follow-up, in particular within the first few weeks.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

et al. 2023

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“…Moreover, Omnipaque can induce changes in intravascular pressure and endothelial permeability. Recently, Omnipaque was reported to induce pituitary apoplexy[ 8 ], status epilepticus[ 9 ], immune hemolytic anemia[ 10 ], trigeminocardiac reflex[ 11 ] and encephalopathy[ 12 ] in some rare cases. In this case, Omnipaque-induced IC remains the most likely diagnosis based on the complete resolution of symptoms with antibiotic therapy and supportive management only.…”

Section: Discussionmentioning

confidence: 99%

Contrast-induced ischemic colitis following coronary angiography: A case report

Qiu¹,

Li²

2023

World J Clin Cases

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Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.

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“…The most common drugs associated with AIHA in the 1970s were methyldopa and penicillin, in the beginning of the 2000s were cefotetan, ceftriaxone [11,44] and piperacillin [49]. Current data indicates as drugs inducing AIHA antibiotics (cefotetan [50,51], ceftriaxone [52][53][54][55], penicillins [56], trimethoprim-sulfamethoxazole [57]), NSAIDs (diclofenac [47]), antineoplastic/chemotherapeutic drugs [11,12,46,58], cimetidine [59], and contrast media [60]. Our patient did not receive any of the medications known to be associated with drug-associated AIHA, and transfusions of PRBC were performed when anaemia became life-threatening.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Challenges in Orthogeriatric Patients with Cold Agglutinin Haemolytic Anaemia: Case Report and Management Algorithm

2022

Ann Case Report

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Most published reports on cold agglutinin (CA) haemolytic anaemia (CAHA), a rare condition with significant perioperative management challenges, are from patients who have undergone cardiothoracic surgery with hypothermia. Here, we report a hip fracture patient with CAHA, and review the perioperative management. This is the second published case report regarding CAHA in an orthopaedic patient. An 86 year old female with a 4-year history of recurrent episodes of CAHA and multiple comorbidities (atrial fibrillation, hypertension, strokes, secondary epilepsy, vascular dementia, and type 2 diabetes mellitus complicated by diabetic retinopathy, osteoporosis, urinary incontinence, recurrent urinary tract infections, and multinodular goitre) was admitted because of a hip fracture. She was commenced on prednisolone a month prior the hip fracture. On admission, her haemoglobin was 69 g/L, lactate dehydrogenase 494 U/L, haptoglobin <0.1 g/L and the blood film showed red blood cell agglutination at room temperature, which dissociated at 37 o C. She required transfusion of 5 units of packed red blood cells during her admission. Her management included intensive temperature monitoring, use of body thermal blanket, warming intravenous and irrigation fluids and medications before administration. Surgery was performed under general anesthesia on the 4th admission day. She received unfractionated heparin for venous thromboembolism prophylaxis, antibiotics for wound infection prophylaxis, continued prednisolone, and started anti-osteoporotic medications. The patient was discharged to another hospital for rehabilitation on the 7th postoperative day. Perioperative examination and treatment of orthogeriatric patients with CAHA is challenging. The pathophysiology of CAHA is shortly revied and a management algorithm is presented.

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Contrast Media-Induced Immune Hemolytic Anemia

Cited by 3 publications

References 12 publications

Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

Contrast-induced ischemic colitis following coronary angiography: A case report

Perioperative Challenges in Orthogeriatric Patients with Cold Agglutinin Haemolytic Anaemia: Case Report and Management Algorithm

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