What is the best luminance contrast weighting-function for image quality optimization? 'Traditional' contrast sensitivity functions (CSFs) have been applied as weighting-functions in image difference metrics. This weighting also resulted in increased sharpness and color-preference, according to previous psychophysical research. We suggest 'contextual' CSFs (cCSFs) and 'contextual' discrimination functions (cVPFs) should provide bases for further improvement; these functions are directly measured from pictorial scenes, modeling threshold and suprathreshold sensitivities within the context of complex masking information. Image quality assessment is understood to require detection/discrimination of masked signals, making 'contextual' CSFs directly relevant.In this investigation, images are weighted with a 'traditional' CSF, cCSF, cVPF and a 'constant' function. Controlled mutations of these functions are also applied as weighting-functions, seeking the optimal band weighting for quality optimization. Image quality, sharpness and naturalness are then assessed in two-alternative forced-choice psychophysical tests. Maximal quality, results from cCSFs and cVPFs, mutated to boost contrast in the higher visible frequencies.