Contrast ultrasonography of the kidney: a new method for evaluation of renal perfusion in vivo.

Lang, Roberto M.; Feinstein, Steven B.; Powsner, Seth M.; McCoy, C E; Frederickson, E D; Neumann, Alex; Goldberg, Leon I.; Borow, K. M.

doi:10.1161/01.cir.75.1.229

Cited by 21 publications

(9 citation statements)

References 20 publications

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“…[23][24][25] Contrast ultrasonography has been proposed for the evaluation of renal perfusion in kidneys. [26][27][28][29] The use of an ultrasonographic contrast agent in combination with color Doppler and PD imaging has been demonstrated to improve visualization of blood flow in kidneys. 1,30,31 In a previous analysis, we compared PD versus gray scale sonography to determine which was more sensitive to a small dose of contrast agent.…”

mentioning

confidence: 99%

Evaluation of change in blood flow by contrast-enhanced power Doppler imaging during norepinephrine-induced renal vasoconstriction.

Arger

Sehgal

Pugh

et al. 1999

Journal of Ultrasound in Medicine

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We evaluated the changes in flow induced by intrarenal infusion of norepinephrine by an ultrasonographic contrast agent and power Doppler imaging. Hypoperfusion was induced in dogs (N = 5) by infusing norepinephrine directly into the renal artery for 30 min at doses of 0.7 microg/kg/min, 1.0 microg/kg/min, and 1.9 microg/kg/min. Contrast agent injections were made before and after each infusion of norepinephrine. The transit of contrast agent through the kidney and color enhancement were measured by computer analysis of power Doppler images. Mean transit time and effective renal plasma flow were measured. The effective renal plasma flow decreased by 29%, 30%, and 64%, respectively, with the increasing doses of norepinephrine. Paralleling this change, the mean transit time, which corresponds to reduction in renal blood flow, increased by 26%, 43%, and 77%, respectively, from the preinfusion value. Regression analysis shows renal blood flow to decrease exponentially with norepinephrine dose. Renal blood flow changes measured by contrast-enhanced imaging correlated closely with the effective renal plasma flow measurements. Computer analysis of contrast-enhanced power Doppler images allowed measurement of renal blood flow. This technique may be useful in assessing renal perfusion during pharmacologic and other therapeutic interventional procedures.

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mentioning

confidence: 99%

Evaluation of change in blood flow by contrast-enhanced power Doppler imaging during norepinephrine-induced renal vasoconstriction.

Arger

Sehgal

Pugh

et al. 1999

Journal of Ultrasound in Medicine

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“…Lang et al [20] showed similar effects using sonicated Renografin. They could also estimate the renal blood flow using calculations based on washout curves for the contrast [20]. Also Albunex (Molecular Biosystems, San Diego, Calif.) helped quantify renal flow in mongrel dogs after injections directly into aorta by means of analysing time-intensity curves of the aorta and renal cortex [21].…”

Section: Preclinical Experimentsmentioning

confidence: 80%

“…It is more than 15 years since Carroll et al demonstrated that gelatin encapsulated gas bubbles injected in the aorta enhanced the renal cortex on grey-scale images [19]. Lang et al [20] showed similar effects using sonicated Renografin. They could also estimate the renal blood flow using calculations based on washout curves for the contrast [20].…”

Section: Preclinical Experimentsmentioning

confidence: 98%

Ultrasound contrast agents and their use in urogenital radiology: status and prospects

Jakobsen

Corréas

2001

Eur Radiol

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Ultrasound contrast agents (USCAs) for intravenous use are usually microbubbles with a mean diameter less than that of a red blood corpuscle and filled with gas. The USCAs may improve information about tissue characteristics and physiology by enhancing B-mode imaging, all Doppler modalities and by means of contrast-specific imaging, e.g. harmonic and stimulated acoustic imaging. Results from preclinical experiments have been promising, and several of these have been reproduced in clinical studies. This includes improved evaluation of renal vasculature and parenchyma, assessment of vesicoureteral reflux in children, assessment of tubal patency in women, and evaluation of prostate diseases and erectile dysfunction in men. Some of the physical limits of the ultrasound technology, as well as the operator-dependent factors, can probably never be overcome by the use of USCAs; however, the development of USCAs is now about to provide uroradiologists with potentially efficacious products for the benefit of the patient.

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“…With the availability of commercial contrast agents and the concomitant use of harmonic ultrasound imaging systems, contrast ultrasound has been used for organ imaging of liver tumors (117), renal perfusion (3,5,55,110), breast tumors (47), prostate cancer (30), and venous thrombi (104).…”

Section: Clinical Noncardiac Imagingmentioning

confidence: 99%

The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond

Feinstein

2004

American Journal of Physiology-Heart and Circulatory Physiology

206

150

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This review discusses the development, current applications, and therapeutic potential of ultrasound contrast agents. Microbubbles containing gases act as true, intravascular indicators, permitting a noninvasive, quantitative analysis of the spatial and temporal heterogeneity of blood flow and volumes within the microvasculature. These shelled microbubbles are near-perfect reflectors of acoustic ultrasound energy and, when injected intravenously into the bloodstream, reflect ultrasound waves within the capillaries without disrupting the local environment. Accordingly, microbubble ultrasound contrast agents are clinically useful in enhancing ultrasound images and improving the accuracy of diagnoses. More recently, ultrasound contrast agents have been used to directly visualize the vasa vasorum and neovascularization of atherosclerotic carotid artery plaques, thus suggesting a new paradigm for diagnosis and treatment of atherosclerosis. Future applications of these microscopic agents include the deliver of site-specific therapy to targeted organs in the body. Medical therapies may use these microbubbles as carriers for newer therapeutic options.

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Contrast ultrasonography of the kidney: a new method for evaluation of renal perfusion in vivo.

Cited by 21 publications

References 20 publications

Evaluation of change in blood flow by contrast-enhanced power Doppler imaging during norepinephrine-induced renal vasoconstriction.

Evaluation of change in blood flow by contrast-enhanced power Doppler imaging during norepinephrine-induced renal vasoconstriction.

Ultrasound contrast agents and their use in urogenital radiology: status and prospects

The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond

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