Contrasting bronchoalveolar leukocyte responses in rats inhaling coal mine dust, quartz, or titanium dioxide: Effects of coal rank, airborne mass concentration, and cessation of exposure

Donaldson, Kenneth; Brown, Gillian; Brown, David M.; Robertson, Marcus; Slight, Joan; Cowie, Hilary; Jones, A. D.; Bolton, Robert; Davis, J. Michael

doi:10.1016/s0013-9351(05)80151-3

Cited by 35 publications

(24 citation statements)

References 16 publications

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“…This might be explained by the possibility that the repeated BALs, in contrast to their single BAL, may have removed a portion of the dust load in this study resulting in lowered chronic AM stimulation [24]. This supports the premise that the primate bronchoscopy model, NAGase activity is useful to rank the fibrogenic potential of respirable dusts, as suggested in previous reports [9,18,30].…”

Section: Discussionsupporting

confidence: 87%

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N-acetyl-beta-D-glucosaminidase activity within BAL from macaques exposed to generic coal dusts

Mack

Griffith

Riling

et al. 1995

Lung

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N-acetyl-beta(beta)-D-glucosaminidase is a lysosomal enzyme secreted by alveolar macrophages in response to phagocytosis of particulate material. Alveolar macrophages participate in the degradation and fibrosis of pulmonary tissue that results in pneumoconiosis. Known quantities of four characterized respirable dusts were bronchoscopically placed into the right caudal lung lobe of macaque monkeys. Bronchoalveolar lavage (BAL) samples were collected from dust-exposed right lung and unexposed left lung of the same individuals at 2-week intervals for 12 weeks after dust instillation. The samples were tested for N-acetyl-beta-D-glucosaminidase activity to determine if the enzyme levels could serve as an indicator of pulmonary injury induced by generic coal dusts when compared to known fibrogenic and nuisance dusts. Installation of generic quartz, anthracite, or TiO2 dusts produced significant elevations of enzyme activity and increased numbers of macrophages in the dust-exposed lobes. Elevations in enzymatic activity and macrophage numbers were greatest in response to generic quartz dust. These results suggest that quantitative levels of N-acetyl-beta-D-glucosaminidase activity may be a useful indicator of acute and chronic lung injury following exposure to fibrogenic and nonfibrogenic dusts.

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Section: Discussionsupporting

confidence: 87%

“…NAGase levels have been previously examined in bronchoalveolar lavage (BAL) specimens from humans and nonhuman primates exposed to coal dust and were useful in distinguishing dust-exposed (fibrotic) lung from unexposed (normal) lung [9,18,30]. Humans with CWP had higher NAGase levels and AM numbers than control subjects [30].…”

Section: Introductionmentioning

confidence: 99%

N-acetyl-beta-D-glucosaminidase activity within BAL from macaques exposed to generic coal dusts

Mack

Griffith

Riling

et al. 1995

Lung

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“…Quartz and coal mine dust are small particles (Ͻ3 m) that would reach the periphery of the lung and could enter the pleural space. They are known to be inflammogenic in the lungs after inhalation, 35,36 playing a causative role in the pathogenesis of silicosis and pneumoconiosis. 37 The lack of response to these highly inflammogenic particles in the pleural exposure model can be explained by their small size (ie, they are rapidly cleared from the pleural space in the flow of pleural fluid).…”

Section: Discussionmentioning

confidence: 99%

Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura

Murphy

Poland

Duffin

et al. 2011

The American Journal of Pathology

288

263

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The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. Direct instillation of long and short CNTs into the pleural cavity, the site of mesothelioma development, produced asbestos-like length-dependent responses. The response to long CNTs and long asbestos was characterized by acute inflammation, leading to progressive fibrosis on the parietal pleura, where stomata of strictly defined size limit the egress of long, but not short, fibers. This was confirmed by demonstrating clearance of short, but not long, CNT and nickel nanowires and by visualizing the migration of short CNTs from the pleural space by single-photon emission computed tomographic imaging. Our data confirm the hypothesis that, although a proportion of all deposited particles passes through the pleura, the pathogenicity of long CNTs and other fibers arises as a result of length-dependent retention at the stomata on the parietal pleura.

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“…The groups for coal dust exposure receiving coal dust inhalation at concentration 6.25 mg/m 3 , 12.5 mg/m 3 , 25 mg/m 3 one hour per day for 28 days which modified from previous study [17]. Coal dust exposure was done by coal dust inhalation equipment that was designed and available in Pharmacology Laboratorium, Medical Faculty, Brawijaya University of Malang.…”

Section: Coal Dust Exposurementioning

confidence: 99%

Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

Setiawan¹,

Darsuni²,

Muttaqien³

et al. 2013

Med-Science

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Contrasting bronchoalveolar leukocyte responses in rats inhaling coal mine dust, quartz, or titanium dioxide: Effects of coal rank, airborne mass concentration, and cessation of exposure

Cited by 35 publications

References 16 publications

N-acetyl-beta-D-glucosaminidase activity within BAL from macaques exposed to generic coal dusts

N-acetyl-beta-D-glucosaminidase activity within BAL from macaques exposed to generic coal dusts

Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura

Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

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