Contrasting genetic influence of PON 1 coding gene polymorphisms L55M and Q192R on individuals’ response to environmental agents

Morcos, Nadia Y.S.; El-Masry, Mohy; Kamal, Maha Moustafa; Galal, Sahar Yacout

doi:10.1016/j.ejmhg.2015.02.007

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…However, Morcos et al (2015) suggested a possible relation between QR genotype and poor OP poisoning prognosis whilebetter prognosis was more related to RR genotype. This is because the PON1R192alloenzyme is more efficient in hydrolysis of many commonly used OPs compared to the PON1 Q192 alloenzyme.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase 1 gene polymorphism and enzymatic activity as a prognostic marker in cases of poisoning by cholinesterase inhibitor pesticides among Egyptians

Darwish

Megahed

Attia

et al. 2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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All rights reserved. Introduction holinesterase inhibitor pesticides poisoning is a serious public health problem in Egypt because of their high morbidity and mortality in young adults. The organophosphorus and carbamates are the most popular cholinesterase inhibitor pesticides used as pest control in both the agricultural sector and residential use(Mansour, 2011). Acute exposure to carbamates and organophosphorus are clinically indistinguishable. Both of them inhibit cholinesterase enzyme activity leading to accumulation of acetylcholine which overstimulates nicotinic and muscarinic receptors. However, in carbamates the chemical bond is reversible leading to shorter duration of toxicity(Pope et al., 2005). There are multiple factors that lead to high susceptibility to poisoning by cholinesterase inhibitors pesticides. One of these factors is the interaction between genetic makeup of individuals and environmental exposurethat has been investigated in multiple studies. The role of the PON1 gene polymorphisms was always suspected due to previous animal knockout studies. They showed that high levels of PON1 protect individuals

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Section: Discussionmentioning

confidence: 99%

Paraoxonase 1 gene polymorphism and enzymatic activity as a prognostic marker in cases of poisoning by cholinesterase inhibitor pesticides among Egyptians

Darwish

Megahed

Attia

et al. 2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…PON1 is shown to participate in the hydrolysis of xenobiotics but the enzyme activity varies based on the presence of polymorphisms. This variability is due to SNPs in the coding region of PON1 gene at positions 55 (L to M) and 192 (Q to R) (Scacci et al, 2003;Morcos et al, 2015). There is a scarcity of data on the effect of PON1 polymorphisms in subjects who are occupationally exposed to heavy metals.…”

Section: Discussionmentioning

confidence: 99%

Research Article Human Serum Paraoxonase (PON-1) and hemochromatosis gene (HFE) gene polymorphisms in occupationally exposed lead workers from Saudi Arabia

Shaik¹,

Alsaeed²,

Faiyaz-Ul-Haque³

et al. 2019

Genet. Mol. Res.

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Serum paraoxonase (PON1) and hemochromatosis (HFE) genes may play important roles in lead toxicity owing to their role in xenobiotic and iron metabolism, respectively. The association between PON1 and HFE genotypes and blood lead levels (BLLs) was examined in lead exposed subjects from Saudi Arabia. The polymorphisms at PON1 L55M, PON1 Q192R, HFE H63D and HFE C282Y (using PCR-RFLP) and their relation to BLLs was evaluated. The recruited subjects (N = 127) were categorized into low BLL group (<10 μg/dL) and high BLL group (>10 μg/dL) according to CDC guidelines. The low BLL group had a mean level of 3.94 µg/dL, while the high BLL group had levels of 15.33 µg/dL (P < 0.001). Overall, the genetic variants, TA and AA in the PON1 L55M were significantly (P = 0.00002 and P = 0.00322, respectively) associated with a risk of lead toxicity and the allele 'A' was a risk factor (P = 0.00002). However, the Q192R genotype of PON1 along with HFE ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (2): gmr18317 A.P. Shaik et al. 2 H63D and HFE C282Y did not significantly increase the risk of developing lead poisoning. Our findings suggest that L55M gene polymorphism influences the susceptibility of subjects to lead exposure and thus it could be a useful biomarker of genetic susceptibility in assessing an individual's risk of damage from heavy metal exposure.

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Contrasting genetic influence of PON 1 coding gene polymorphisms L55M and Q192R on individuals’ response to environmental agents

Cited by 2 publications

References 19 publications

Paraoxonase 1 gene polymorphism and enzymatic activity as a prognostic marker in cases of poisoning by cholinesterase inhibitor pesticides among Egyptians

Paraoxonase 1 gene polymorphism and enzymatic activity as a prognostic marker in cases of poisoning by cholinesterase inhibitor pesticides among Egyptians

Research Article Human Serum Paraoxonase (PON-1) and hemochromatosis gene (HFE) gene polymorphisms in occupationally exposed lead workers from Saudi Arabia

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