Contrasting Roles of Cannabidiol as an Insecticide and Rescuing Agent for Ethanol–induced Death in the Tobacco Hornworm Manduca sexta

Park, Sang‐Hyuck; Staples, Shawnnah; Gostin, Eric L.; Smith, Jeffrey P.; Vigil, Jose J.; Seifried, Dustin; Kinney, Chad A.; Pauli, Christopher S.; Heuvel, Brian D. Vanden

doi:10.1038/s41598-019-47017-7

“…The results indicate that flies display a significant preference for phytocannabinoids over time. A recent study has showed that Tobacco Hornworm Manduca sexta larvae prefer the food with low concentration of CBD over higher dose of CBD, and high CBD concentration is detrimental for larvae development 36 . However, no aversive response to phytocannabinoids was detected in this study.…”

Section: Discussionmentioning

confidence: 99%

Cannabinoids modulate food preference and consumption inDrosophila melanogaster

He

¹

,

Tan

²

,

Ng

³

et al. 2020

Preprint

View full text Add to dashboard Cite

Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of their sensory functions. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.

show abstract

“…The results indicate that ies display a signi cant preference for phytocannabinoids over time. A recent study has showed that Tobacco Hornworm Manduca sexta larvae prefer the food with low concentration of CBD over higher dose of CBD, and high CBD concentration is detrimental for larvae development 36 . However, no aversive response to phytocannabinoids was detected in this study.…”

Section: Discussionmentioning

confidence: 99%

Cannabinoids Modulate Food Preference and Consumption in Drosophila Melanogaster

He

¹

,

Tan

²

,

Ng

³

et al. 2020

Preprint

1

3

0

View full text Add to dashboard Cite

Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of their sensory functions. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.

show abstract

“…The results indicate that flies display a significant preference for phytocannabinoids over time. A recent study has showed that Tobacco Hornworm Manduca sexta larvae prefer the food with low concentration of CBD over higher dose of CBD, and high CBD concentration is detrimental for larvae development 38 . However, no aversive response to phytocannabinoids was detected in this study.…”

Section: Discussionmentioning

confidence: 99%

Cannabinoids modulate food preference and consumption in Drosophila melanogaster

He

¹

,

Tan

²

,

Ng

³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of two important sensory regulators Poxn and Orco. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.

show abstract

Contrasting Roles of Cannabidiol as an Insecticide and Rescuing Agent for Ethanol–induced Death in the Tobacco Hornworm Manduca sexta

Cited by 35 publications

References 43 publications

Cannabinoids modulate food preference and consumption inDrosophila melanogaster

Cannabinoids modulate food preference and consumption inDrosophila melanogaster

Cannabinoids Modulate Food Preference and Consumption in Drosophila Melanogaster

Cannabinoids modulate food preference and consumption in Drosophila melanogaster

Contact Info

Product

Resources

About