Contribución de la SPECT cerebral de transportadores de dopamina en el diagnóstico diferencial de los parkinsonismos

Lorenzo-Bosquet, Carles; Rodríguez, Francesc Miquel; Bielsa, Isabel; Milà, M. Immaculada Dinarès; Bruix, Santiago Aguadé; Conesa, Joan Castell

doi:10.1016/s0025-7753(04)74224-4

Cited by 18 publications

(2 citation statements)

References 23 publications

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“…CT and MRI neuroimaging do play an important role in the diagnosis of patients with vascular parkinsonism. Radiotracer neuroimaging techniques allow to study the integrity of the dopaminergic nigrostriatal system and are therefore a valuable tool to diagnose neurodegenerative parkinsonisms (Lorenzo Bosquet et al, 2004; Tolosa et al, 2007). Positron emission tomography techniques demonstrate the disruption of selective patterns of regional cerebral metabolism and neurotransmitter systems associated with subcortical degenerations, such as Parkinson's disease, striatonigral degeneration, progressive supranuclear palsy, and corticobasal degeneration (Antonini and Isaias, 2009; Huang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study

Menéndez-González

Tavares

Zeidan

et al. 2014

Front. Aging Neurosci.

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The [123I]ioflupane—a dopamine transporter radioligand—SPECT (DaT-SPECT) has proven to be useful in the differential diagnosis of tremor. Here, we investigate the diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT. Therefore, 30 patients with tremor and normal DaT-SPECT were followed up for 2 years. In 18 cases we were able to make a diagnosis. The residual 12 patients underwent a second DaT-SPECT, were then followed for additional 12 months and thereafter the diagnosis was reconsidered again. The final diagnoses included cases of essential tremor, dystonic tremor, multisystem atrophy, vascular parkinsonism, progressive supranuclear palsy, corticobasal degeneration, fragile X–associated tremor ataxia syndrome, psychogenic parkinsonism, iatrogenic parkinsonism and Parkinson's disease. However, for 6 patients the diagnosis remained uncertain. Larger series are needed to better establish the relative frequency of the different conditions behind these cases.

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Section: Introductionmentioning

confidence: 99%

Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study

Menéndez-González

Tavares

Zeidan

et al. 2014

Front. Aging Neurosci.

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“…Monitoring neurotransmitters level is used for assessing the nervous system function and clarifying the disease mechanisms (if any). Moreover, the detection of this class of catecholamines is of high importance in early clinical diagnosis of various neurological diseases 3 such as neuroblastomas 4 , pheochromocytomas 5 , Parkinsonism 6 , Schizophrenia 7 , Alzheimer 8 , Down’s syndrome and multiple sclerosis 9 – 11 .…”

Section: Introductionmentioning

confidence: 99%

Colorimetric Fingerprints of Gold Nanorods for Discriminating Catecholamine Neurotransmitters in Urine Samples

Jafarinejad

Ghazi‐Khansari

Ghasemi

et al. 2017

Sci Rep

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Catecholamine neurotransmitters, generally including dopamine (DA), epinephrine (EP) and norepinephrine (NE) are known as substantial indicators of various neurological diseases. Simultaneous detection of these compounds and their metabolites is highly recommended in early clinical diagnosis. To this aim, in the present contribution, a high performance colorimetric sensor array has been proposed for the detection and discrimination of catecholamines based on their reducing ability to deposit silver on the surface of gold nanorods (AuNRs). The amassed silver nanoshell led to a blue shift in the longitudinal localized surface plasmon resonance (LSPR) peak of AuNRs, creating a unique pattern for each of the neurotransmitters. Hierarchical cluster analysis (HCA) and linear discriminate analysis (LDA) pattern recognition techniques were employed to identify DA, EP and NE. The proposed colorimetric array is able to differentiate among individual neurotransmitters as well as their mixtures, successfully. Finally, it was shown that the sensor array can identify these neurotransmitters in human urine samples.

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Sensitive determination of neurotransmitters in urine by microchip electrophoresis with multiple-concentration approaches combining field-amplified and reversed-field stacking

Zhang

Wang

et al. 2016

Journal of Chromatography B

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Contribución de la SPECT cerebral de transportadores de dopamina en el diagnóstico diferencial de los parkinsonismos

Cited by 18 publications

References 23 publications

Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study

Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study

Colorimetric Fingerprints of Gold Nanorods for Discriminating Catecholamine Neurotransmitters in Urine Samples

Sensitive determination of neurotransmitters in urine by microchip electrophoresis with multiple-concentration approaches combining field-amplified and reversed-field stacking

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