Contribuição da fitoquímica para o desenvolvimento de um país emergente

Braz-Filho, Raimundo

doi:10.1590/s0100-40422010000100040

Cited by 38 publications

(36 citation statements)

References 29 publications

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“…50,51 According to the results of phytochemical in Spondias mombin, there is the presence of terpene origin of substances in the extract obtained from the leaves. Moronkola et al 52 reported more than 54 components in the essential oil composition of S. mombin, and caryophyllene the major compound hence corroborating the findings.…”

Section: Phytochemical Prospectionmentioning

confidence: 99%

Pharmacognostic Characterization of Spondias mombin L. (Anacardiaceae)

Vasconcelos¹,

Vasconcelos²,

Randau³

2016

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Background: Spondias mombin L. is fruit specie found in Tropical America and the coast of Africa, popularly known as cajazeira. Several researches with extract of leaflets show a diversity of promising pharmacological activities such as antibacterial activity, antiviral against dengue virus type 2, anti diabetic, among others. Objective: This paper aims to study the anatomical characteristics, phytochemical and histochemical from leaves of this species. Materials and Methods: Cross and paradermic sections from leaves were submitted to double staining with astra blue and safranin process for the anatomical study. Anatomical analysis of the structures was performed using an optical microscope. For ultra structure analysis, the leaf fragments, after processing and gold coating, were observed under scanning electron microscopy (SEM). The phytochemical analyses were performed using thin layer chromatography and the histochemical analyses using specific reagents for each metabolite group. Results: The leaf has anomocytic and tetracytic stomata distributed on abaxial surface. The midrib has convex symmetry with collateral vascular bundles in a closed arc disposition. The phytochemical showed the presence of mono and sesquiterpenes, triterpenes and steroids, hydrolysable tannins, phenylpropanoid glycosides, cinnamic derivatives and flavonoids. The histochemical tests allow us to state that phenolic compounds are found in the palisade parenchyma cells. Lignins can be found in woody vascular bundles and in perivascular sclerenchyma fibres. The volatile oils were evidenced in the schizogenous cavity, present in the parenchyma of the midrib. Conclusion: The results allowed characterizing anatomically the leaves of this species, outlining a profile of its phytochemical constituents and, in addition, determining which anatomical structures of storage of these metabolites by the plant.

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Section: Phytochemical Prospectionmentioning

confidence: 99%

Pharmacognostic Characterization of Spondias mombin L. (Anacardiaceae)

Vasconcelos¹,

Vasconcelos²,

Randau³

2016

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“…Huang et al 2003, reported LD50 values on Pomacea canaliculata Lamarck of 22 ppm at 48 hours, using extracts of Sapindus mukorossi L., this value is similar to the value obtained with the best formulations used in this work. (Herrera et al, 2007;Braz Filho, 2010), S. saponaria presents, among other compounds, a complex mixture of saponins with oleanane skeleton. S. mammosum is characterized by the presence of steroidal glycoalkaloid, which solanine [3] and solasonine [4], are referred to as the major ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Molluscicidal activity of the aqueous extracts from Solanum mammosum L., Sapindus saponaria L. and Jatropha curcas L. against Pomacea canaliculata

Quijano

Riera-Ruiz

Barragán

et al. 2014

Emir. J. Food Agric

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Biomolluscicides development is of great interest in pest management to avoid the effects on the environment caused by synthetic molluscicides. The Species: Solanum mammosum L., Sapindus saponaria L. and Jatropha curcas L. have demonstrated molluscicidal properties against Pomacea canaliculata. This study was carried with mixtures of aqueous extracts of these plants in order to check for a synergistic effect between them. Extracts obtained from each species were evaporated and lyophilized. By using a simplex centroid design were obtained ten mixes for testing. All of them were diluted to 500ppm and tested on adult snails for 24 hours of exposure followed by 24 hours of recovery on tab water. Those mixes that showed the best results of mortality were chosen to determine the median lethal dose. The formulations S. saponaria (100%) and S. mammosum -S. saponaria (50%-50%) showed the best results of mortality with LD50 values of 24.04 ppm and 17.78 ppm respectively, with no significant differences between them (p> 0.05). These results showed that a synergistic effect is not produced in the activity of these plants when the extracts mixture was performed.

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“…These natural molecules provide the initial structure for structural modifications to be performed to optimize pharmacological properties. Thus, these modified compounds can give rise to new drugs 4, 5…”

Section: Introductionmentioning

confidence: 99%

Inverse virtual screening studies of selected natural compounds from cerrado

Carregal

Comar

Alves

et al. 2012

Int J of Quantum Chemistry

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Several medicinal plants have been studied in recent years in Brazil. However, despite many efforts, the pharmacological mechanisms of many natural products are still unknown. Several biological assays in vivo and in vitro are needed to further address this issue, which increases the cost of these studies. The main goal of this study was to apply the methodology of inverse virtual screening (IVS), followed by docking studies, and refinement by molecular dynamics (MD) simulation and quantum mechanical/molecular mechanical to determine the pharmacological receptors for five selected natural products with the exception of the benzoxazinone isolated from the exudate of the radicle of the crop species which were mainly isolated from the Cerrado species, obtained from Cerrado, a typical Brazilian biome. Initially, the structures of the natural compounds were generated using the online software program sc-PDB, which searches for molecular targets deposited in the protein data bank. The ligands were docked against target proteins found in IVS stepforming complexes, which were refined again using MD simulations by ff03 force field for 1 ns. Finally, the binding energy for each complex was obtained by the ONIOM (PM6:UFF) method. As a result, these calculations suggested possible molecular targets for these natural compounds. Among the targets found were 1EH4, 2A4Z, 1H49, 1JT2, 2BNJ, and 3FW9, which are involved in cancer and rheumatoid arthritis pathologies, indicating that they are promising molecular targets. In this study, we proposed a biological assay for these natural compounds. The results indicate that structural changes may be proposed to generate compounds that are able to bind more strongly to the receptor and become new drug candidates, thus optimizing the search for lead natural compounds.

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Contribuição da fitoquímica para o desenvolvimento de um país emergente

Cited by 38 publications

References 29 publications

Pharmacognostic Characterization of Spondias mombin L. (Anacardiaceae)

Pharmacognostic Characterization of Spondias mombin L. (Anacardiaceae)

Molluscicidal activity of the aqueous extracts from Solanum mammosum L., Sapindus saponaria L. and Jatropha curcas L. against Pomacea canaliculata

Inverse virtual screening studies of selected natural compounds from cerrado

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