Contributed Session I: Larger ON-pathway deficits in rod-dominated disease than cone-dominated disease

Hathibelagal, Amithavikram R.; Bhutia, Phuntsok; Das, Mritunjoy; Babu, Helna; GaneshRao, Shonraj Balle

doi:10.1167/jov.22.3.1

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“…This is the first study to establish a wide age-related normative database for this tablet-based test, which is important, because it allows us to distinguish age-related changes from disease-specific defects. This test will be especially useful in rod-dominated diseases, where ON pathway parameter can potentially act as a easy-to-use surrogate marker of rod photoreceptor function as shown in pilot data so far [ 31 ] in lieu of long adaptation tests. Future studies should iterate and identify the optimum ‘number of trials’ required to balance between the need for robust data and the time taken for test completion.…”

Section: Discussionmentioning

confidence: 99%

Age-related decline in function of ON and OFF visual pathways

et al. 2022

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Purpose A simple psychophysical paradigm is available as a digital application in iOS devices such as iPad to measure the function of ON and OFF visual pathways. However, an age-matched normative database is not readily available. The purpose of the study is to evaluate the response of ON and OFF visual pathways as a function of age. Methods 158 normal healthy adults (84 males and 74 females) whose age ranged 18–80 years participated in the study. None of them had any ocular disease (except cataract of grade II or less) and visual acuity of ≤ 20/25. Monocular testing (only one eye) was performed on the ‘EyeSpeed’ application on an iPad at 40cm distance. The targets ranged between 1 to 3 light or dark squares presented randomly in a noise background and participants responded by indicating the number of squares by touching the screen as fast as possible. The main outcome variables are reaction time, accuracy and performance index (1 / speed * accuracy). Results The median reaction time was shorter (Median (IQR): 1.53s (0.49) [dark] Vs 1.76s (0.58) [light], p < 0.001) and accuracy was higher (97.21% (3.30) [dark] Vs 95.15% (5.10) [light], p < 0.001) for dark targets than the light targets. Performance index and reaction time for both target types significantly correlated with age (ρ = -0.41 to -0.43; p < 0.001). Conclusions This normative database will be useful to quantify disease-specific defects. More importantly, the ON pathway function can potentially serve as a surrogate for rod photoreceptor function.

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Section: Discussionmentioning

confidence: 99%