2023
DOI: 10.1038/s41467-023-41256-z
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Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes

Qiao Fan,
Hengtong Li,
Xiaomeng Wang
et al.

Abstract: Neovascular age-related macular degeneration (nAMD), along with its clinical subtype known as polypoidal choroidal vasculopathy (PCV), are among the leading causes of vision loss in elderly Asians. In a genome-wide association study (GWAS) comprising 3,128 nAMD (1,555 PCV and 1,573 typical nAMD), and 5,493 controls of East Asian ancestry, we identify twelve loci, of which four are novel ($$P \, < \, 1.19\times {10}^{-8}$$ P < … Show more

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