Contribution of epigenetic risk factors but not p53 codon 72 polymorphism to the development of cervical cancer in Northeastern Thailand

Settheetham-Ishida, Wannapa; Singto, Yuwanee; Yuenyao, Pissamai; Tassaneeyakul, Wichittra; Kanjanavirojkul, Nipa; Ishida, Takafumi

doi:10.1016/j.canlet.2004.03.039

Cited by 27 publications

(16 citation statements)

References 25 publications

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“…Among healthy women, an HPV infection was able to clear within 1-2 years (Klug et al, 2009;Schiffman et al, 2007) and <1% of HPV-positive women would go on to develop cervical cancer (Josefsson et al, 2000;Nagpal et al, 2002). The current report indicates that the involvement of other factors such as sexual behavior, personal and partner smoking habits and genetic backgrounds are likely co-factors with HPV for an increased risk of developing cervical cancer (Settheetham-Ishida et al, 2004;Settheetham-Ishida et al, 2005;Au et al, 2007;Almonte et al, 2008).…”

Section: Discussionmentioning

confidence: 59%

“…Among these, polycyclic aromatic hydrocarbons (PAHs) and volatile N-nitrosamines are considered to be the main carcinogens (Shields, 2002;Alam et al, 2008;Lodovici and Bigagli, 2009). Smoking exposure-a welldocumented environmental factor-is a leading cause of many types of cancer such as lung, esophageal, gastric, bladder, liver and cervical cancers (Tredaniel et al, 1997;Kinjo et al, 1998;Gallus et al, 2001;Sobue et al, 2002 ;Settheetham-Ishida et al, 2004;Samanic et al, 2006;Settheetham-Ishida et al, 2006;Syrjanen et al, 2007;Pesch et al, 2011). An increased risk of cervical cancer associated with tobacco smoking has been found in many studies (Haverkos et al, 2003;SettheethamIshida et al, 2004;Garland et al, 2011;Yetimalar et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.97 (p<0.001) and an adjusted OR of 38.07 (p<0.001) were observed. Early age at first sexual exposure, and multiple sexual partners increased the risk of cervical cancer with ORs ranging between 1.73-2.78 (p<0.05). The interval between menarche and first sexual intercourse <6 years resulted in a significant increase in the risk for cervical cancer with ORs ranging between 3.32-4.09 and the respective adjusted OR range for the 4-5 and 2-3 year-old groups were 4.09 and 2.92. A higher risk was observed among subjects whose partner had smoking habits, whether currently or formerly; with respective ORs of 3.36 (p<0.001) and 2.17 (p<0.05); and respective adjusted ORs of 2.90 (p<0.05) and 3.55 (p<0.05). Other smoking characteristics of the partners including smoking duration ≥ 20 years, number of cigarettes smokes ≥ 20 pack-years and exposure time of the subject to passive smoking ≥ 5 hrs per day were found to be statistically significant risks for cervical cancer with adjusted ORs of 3.75, 4.04 and 11.8, respectively. Our data suggest that the risk of cervical cancer in Thai women is substantially associated with smoking characteristics of the partner(s), the interval between menarche and first sexual intercourse as well as some other aspects of sexual behavior.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…There were three studies performed in Taiwan of China (Wu et al, 2003;Wu et al, 2004;Tsai et al, 2007), two in the USA (Slattery et al, 1989;Coker et al, 2002), two in India (Sobti et al, 2006;Sobti et al, 2008), one in Japan (Tajima et al, 1990), one in Thailand (SettheethamIshida et al, 2004), one in Korea (Sull et al, 2004), and one in Singapore (Tay et al, 2004). Five studies adjusted the conventional covariates (Slattery et al, 1989;Coker et al, 2002;Wu et al, 2003;Settheetham-Ishida et al, 2004;Tay et al, 2004).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…All of the cases were histological, pathologically or cytological confirmed as cervical cancer, of them, five studies did not distinguish the type (CC) (Slattery et al, 1989;Tajima et al, 1990;SettheethamIshida et al, 2004;Sobti et al, 2006;Sobti et al, 2008), four studies clearly divided indicated the type (CIN) and divided according to their pathologic stage (CIN 1, 2, or 3) (Wu et al, 2003;Sull et al, 2004;Wu et al, 2004;Tsai et al, 2007), two studies clearly divided the type to HSIL and LSIL (Coker et al, 2002;Tay et al, 2004), one study reported ICC (Sull et al, 2004). Controls were mainly healthy populations, and matched with age, gender, or cancer-free, six were hospital-based (HB) (Slattery et al, 1989;Tajima et al, 1990;Settheetham-Ishida et al, 2004;Sull et al, 2004;Tay et al, 2004;Sobti et al, 2006;Sobti et al, 2008), five were population-based (PB) (Coker et al, 2002;Wu et al, 2003;Wu et al, 2004;Tsai et al, 2007). There were three studies performed in Taiwan of China (Wu et al, 2003;Wu et al, 2004;Tsai et al, 2007), two in the USA (Slattery et al, 1989;Coker et al, 2002), two in India (Sobti et al, 2006;Sobti et al, 2008), one in Japan (Tajima et al, 1990), one in Thailand (SettheethamIshida et al, 2004), one in Korea (Sull et al, 2004), and one in Singapore (Tay et al, 2004).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Passive Smoking and Cervical Cancer Risk: A Meta-analysis Based on 3,230 Cases and 2,982 Controls

Zeng¹,

Xiong²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: Passive smoking has been considered as a risk factor of many cancers. To examine whether it might also pose a risk for cervical cancer, we performed a meta-analysis based on published case-control studies. Methods: We searched the PubMed database and references of included studies up to February 10th, 2012 for relevant studies. After two authors independently assessed the methodological quality and extracted data, a meta-analysis was conducted using CMA v2 software. Publication bias was evaluated by funnel plot, using Egger's and Begg's tests. Results: Finally 11 eligible studies yielded, involving 3,230 cases and 2,982 controls. The results showed that women who never smoke but exposed to smoking experience a 73% increase in risk of cervical cancer compared with non-exposed women (OR = 1.73, 95% CI = 1.35 -2.21, p<0.001). Subgroup and sensitivity analyses indicated this result to be robust. Moderate publication bias was detected by visualing funnel plot, Egger's and Begg's tests. Conclusion: Based on currently available evidence, the findings of this meta-analysis suggests that passive smoking significantly and independently increases the risk of cervical cancer.

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“…We have studied TP53 codon 72 polymorphism and cancer susceptibility in several cancers in Southeast Asia (Tiwawech et al 2003;Kietthubthew et al 2003;Settheetham-Ishida et al 2004. In this study, we have screened for the TP53 codon 72 polymorphism among ethnic groups of Southeast Asia and Oceania to fill in the map of the distribution of this polymorphism.…”

Section: Introductionmentioning

confidence: 99%

TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania

et al. 2007

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Distribution of a single nucleotide polymorphism in the TP53 codon 72 (Arg/Pro) was studied in Southeast Asia and Oceania where information about this polymorphism was lacking. A polymerase chain reaction restriction fragment length polymorphism method was employed to genotype a total of 733 subjects from 12 populations in insular Southeast Asia and Oceania. These populations have been classified as either an Austronesianspeaking group or Papuan-speaking group. The p53Arg frequencies ranged from 0.06 in the Seramese to 0.62 in the Kahayan with an average frequency of 0.38. No significant correlation between the p53Arg frequency and latitude was observed in the 12 populations tested (P > 0.05), whereas a significant correlation was obtained for the relationship between frequency and longitude among 9 Austronesian or the whole 12 populations tested (P < 0.01). A longitudinal cline of the p53Arg frequencies may reflect the history of the Austronesian's migration and local admixture with indigenous Papuan speakers who had probably harbored low p53Arg frequencies.

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Contribution of epigenetic risk factors but not p53 codon 72 polymorphism to the development of cervical cancer in Northeastern Thailand

Cited by 27 publications

References 25 publications

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Passive Smoking and Cervical Cancer Risk: A Meta-analysis Based on 3,230 Cases and 2,982 Controls

TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania

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