Contribution of genetic variant identified in HHEX gene in the overweight Saudi patients confirmed with type 2 diabetes mellitus

Alfaifi, Mohammed

doi:10.1016/j.sjbs.2021.10.028

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…because to the rising frequency of hyperglycemia. There has been a surge of interest in identifying HHEX genetic marker [13]. HHEX is essential for insulin sensitivity and secretion, as well as for cell growth and differentiation, The development of the blood cells liver, pancreas, and heart in several species is similarly regulated by HHEX.…”

Section: Discussionmentioning

confidence: 99%

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Obesity-Related Type 2 Diabetes Mellitus and HHEX Gene rs1111875 C/T Polymorphisms in Iraqi Population.

Nisreen Qassem Shaker,

Seenaa Kadhum Ali

2023

J. K. Chem. Sci.

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type 2 diabetes mellitus(T2DM) is a complex metabolic disease. Diabetes mellitus has quadrupled globally in the last three decades. Many studies have shown how genetic diversity contributes to the development and progression of T2DM. The hematopoietic expressed homeobox (HHEX) gene is hypothesized to be linked to the risk of T2DM. The aim of this study was to look at the association of the HHEX gene polymorphism (rs1111875 C/T) with T2DM in the Iraqi population and see if obese individuals were affected more than other patients. Methods: 100 T2DM obese and 100 controls obese. The RFLP -PCR assay Technique was used to genotype HHEX rs1111875 C/T, making use of newly-designed primers. Results: The study's parameters demonstrate no significant difference between T2DM obese and obese control groups. The study concluded that there is no significant difference in genotypes Codominant, Dominant, Recessive, and Additive genotype between groups for HHEX rs1111875 C/T. and Chol, TG, and VLDL were significant between CC and CT, age was borderline. There is a negative relationship between (BMI and CHO and TG) and (insulin and HOMA-IR and LDL, VLDL). In conclusion, according to the findings of this study, the rs1111875 C/T polymorphism in the HHEX gene revealed no significant difference in genotypes in any of the codominant, dominant, recessive, or additive models.

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Section: Discussionmentioning

confidence: 99%

“…The HHEX is also called HEX, PRHX, and PRH [15]. The HHEX gene has 4 exons and is found on chromosome 10q [13] [14]. The gene's generated protein acts as a transcription factor in the leading pathway (known as Wnt signaling) and is crucial for the initial assessment of the ventral pancreas and liver [14].…”

Section: Introductionmentioning

confidence: 99%

Obesity-Related Type 2 Diabetes Mellitus and HHEX Gene rs1111875 C/T Polymorphisms in Iraqi Population.

Nisreen Qassem Shaker,

Seenaa Kadhum Ali

2023

J. K. Chem. Sci.

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“…Molecular biology investigations have linked genetic variants in number of genes with T2DM. Some of these include PPARG [10], HNF4A [11], GLIS3 [12], MTNR1B [13], IRS-2 [14], NOTCH2 [15], WFS-1 [16], GCK [17], GCKR [18], NEUROD1 [19], HHEX [20], SLC30A8 [21], VEGFA [22] and CAP10 [23]. Other major players involved in the progression of T2DM includes obesity [24], sedentary lifestyle [25], poor diet [26] the metabolic [27] and environmental [28] factors.…”

Section: Introductionmentioning

confidence: 99%

Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study

et al. 2023

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Genome-wide association studies have greatly increased the number of T2DM associated risk variants but most of them have focused on populations of European origin. There is scarcity of such studies in developing countries including Pakistan. High prevalence of T2DM in Pakistani population prompted us to design this study. We have devised a two stage (the discovery stage and validation stage) case-control study in Pashtun ethnic population in which 500 T2DM cases and controls each have been recruited to investigate T2DM genetic risk variants. In discovery stage Whole Exome Sequencing (WES) was used to identify and suggest T2DM pathogenic SNPs, based on SIFT and Polyphen scores; whereas in validation stage the selected variants were confirmed for T2DM association using MassARRAY genotyping and appropriate statistical tests. Results of the study showed the target positive association of rs1801282/PPARG (OR = 1.24, 95%Cl = 1.20–1.46, P = 0.010), rs745975/HNF4A (OR = 1.30, 95%Cl = 1.06–1.38, P = 0.004), rs806052/GLIS3 (OR = 1.32, 95%Cl = 1.07–1.66, P = 0.016), rs8192552/MTNR1B (OR = 1.53, 95%Cl = 0.56–1.95, P = 0.012) and rs1805097/IRS-2 (OR = 1.27, 95%Cl = 1.36–1.92, P = 0.045), with T2DM; whereas rs6415788/GLIS3, rs61788900/NOTCH2, rs61788901/NOTCH2 and rs11810554/NOTCH2 (P>0.05) showed no significant association. Identification of genetic risk factors/variants can be used in defining high risk subjects assessment, and disease prevention.

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Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis

et al. 2023

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Contribution of genetic variant identified in HHEX gene in the overweight Saudi patients confirmed with type 2 diabetes mellitus

Cited by 5 publications

References 43 publications

Obesity-Related Type 2 Diabetes Mellitus and HHEX Gene rs1111875 C/T Polymorphisms in Iraqi Population.

Obesity-Related Type 2 Diabetes Mellitus and HHEX Gene rs1111875 C/T Polymorphisms in Iraqi Population.

Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study

Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis

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